Zobrazeno 1 - 10
of 17
pro vyhledávání: '"Yunwon Moon"'
Autor:
Gwan-Jun Lee, Youn Ju Kim, Bongju Park, Sujin Yim, Chansang Park, Hyunsoo Roh, Yunwon Moon, Je Kyung Seong, Hyunsung Park
Publikováno v:
Cell Death and Disease, Vol 13, Iss 4, Pp 1-12 (2022)
Abstract Wnt5a, a prototypic non-canonical Wnt, is an inflammatory factor elevated in the sera of obese humans and mice. In the present study, fat-specific knockout of Wnt5a (Wnt5a-FKO) prevented HFD-induced increases in serum Wnt5a levels in male C5
Externí odkaz:
https://doaj.org/article/476db7fb84ee44ce9421a0d5e7bbe691
Autor:
Yunwon Moon, Su Mi Choi, Soojeong Chang, Bongju Park, Seongyeol Lee, Mi-Ock Lee, Hueng-Sik Choi, Hyunsung Park
Publikováno v:
PLoS ONE, Vol 10, Iss 6, p e0130911 (2015)
This study evaluated HIF-1α inhibitors under different hypoxic conditions, physiological hypoxia (5% O2) and severe hypoxia (0.1% O2). We found that chenodeoxy cholic acid (CDCA) reduced the amount of HIF-1α protein only under physiological hypoxia
Externí odkaz:
https://doaj.org/article/1cf4372dfb534fee8fbf15e75c888069
Publikováno v:
Molecules and Cells
Hypoxia induces the expression of several genes through the activation of a master transcription factor, hypoxia-inducible factor (HIF)-1α. This study shows that hypoxia strongly induced the expression of two carboxypeptidases (CP), CPA4 and CPE, in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3d53e88de7a0a31e07746de4327d62f
http://europepmc.org/articles/PMC7700838
http://europepmc.org/articles/PMC7700838
Autor:
Yunwon Moon, Sehyun Chae, Sujin Yim, Eun Gyeong Yang, Jungwoo Choe, Jiyeon Hyun, Rakwoo Chang, Daehee Hwang, Hyunsung Park
Publikováno v:
iScience. 25(7)
Clioquinol (CQ) is a hypoxic mimicker to activate hypoxia-inducible factor-1α (HIF-1α) by inhibiting HIF-1α specific asparaginyl hypoxylase (FIH-1). The structural similarity of the Jumonji C (JmjC) domain between FIH-1 and JmjC domain-containing
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::acdf70ebc0fc3b454ce3ff735eb13fec
https://pubmed.ncbi.nlm.nih.gov/35754713
https://pubmed.ncbi.nlm.nih.gov/35754713
Autor:
Min Hwa Shin, Daehee Hwang, Yunwon Moon, Hyunsung Park, Sehyun Chae, Kyung Mi Lee, Seon Ah Lim, Tae Jin Kim, Cassian Yee
Publikováno v:
Cancers, Vol 13, Iss 1904, p 1904 (2021)
Cancers
Volume 13
Issue 8
Cancers
Volume 13
Issue 8
Simple Summary In patients with advanced cancer, hypoxic stress shapes NK cells toward tumor-resistant and immunosuppressive phenotypes. Therefore, a strategy to restore NK cell function within hypoxia would be crucial for successful tumor immunother
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3b249ed4f6990e5891a68a64ac4146ad
https://www.mdpi.com/2072-6694/13/8/1904
https://www.mdpi.com/2072-6694/13/8/1904
Autor:
Ingyum Kim, Soojeong Chang, Seongwook Yoo, Hyunsung Park, Bongju Park, Yunwon Moon, Sehyun Chae, Daehee Hwang, Seongyeol Lee
Publikováno v:
Biochimica et biophysica acta. Gene regulatory mechanisms. 1863(11)
H19 is a maternally-expressed imprinted gene that encodes long non-coding RNA. Chromatin immunoprecipitation (ChIP)-sequencing analyses of human adipose-derived stem cells (hADSCs) showed that hypoxia induced trimethylation of 4th lysine residue of h
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c18f376fda6b19e2c03b4ab9209c7802
https://pubmed.ncbi.nlm.nih.gov/33035707
https://pubmed.ncbi.nlm.nih.gov/33035707
Distinct hypoxic regulation of preadipocyte factor-1 (Pref-1) in preadipocytes and mature adipocytes
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular Cell Research. 1865:334-342
Preadipocyte factor-1 (Pref-1) is a secretory soluble protein, which exerts pleiotropic effects on maintenance of cancer stem cell characteristics and commitment of mesenchymal stem cell lineages by inhibiting adipogenesis. Observations that obesity
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5122d790a5716c50f82799914a16b711
https://doi.org/10.1016/j.bbamcr.2017.11.008
https://doi.org/10.1016/j.bbamcr.2017.11.008
Autor:
Eun Gyeong Yang, Yunwon Moon, Seongyeol Lee, Jieon Lee, Daehee Hwang, Ho-Youl Lee, Sehyun Chae, Hyunsung Park, Bongju Park
Publikováno v:
Nucleic Acids Research
Hypoxia increases both active and repressive histone methylation levels via decreased activity of histone demethylases. However, how such increases coordinately regulate induction or repression of hypoxia-responsive genes is largely unknown. Here, we
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d2ef050eab98c1392c1bedbfe788e20f
http://europepmc.org/articles/PMC5714201
http://europepmc.org/articles/PMC5714201
Publikováno v:
FEBS Letters. 590:3407-3415
Activation of Raf reduces the repressive histone mark H3K27me3 at the INK4a locus by inducing the H3K27me3 demethylase JMJD3. During hypoxia, the catalyitc activity of JMJD3 is reduced due to the limited availability of O2 as a substrate. In our stud
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::19c03b62b9263b4859465f0c99423880
https://doi.org/10.1002/1873-3468.12375
https://doi.org/10.1002/1873-3468.12375
Publikováno v:
BMB Reports
Liver cells experience hypoxic stress when drug-metabolizing enzymes excessively consume O2 for hydroxylation. Hypoxic stress changes the transcription of several genes by activating a heterodimeric transcription factor called hypoxia-inducible facto
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::92122cee0bc885c3c8af6b7ffac8aba4
https://doi.org/10.5483/bmbrep.2016.49.3.188
https://doi.org/10.5483/bmbrep.2016.49.3.188