Zobrazeno 1 - 10
of 97
pro vyhledávání: '"Yunqing Ma"'
Publikováno v:
Practical Laboratory Medicine, Vol 39, Iss , Pp e00380- (2024)
Objectives: Patients with VEXAS syndrome carry mutations of UBA1 gene coding for the E1 enzyme. The three most frequent mutations are p.M41T(122T > C), p.M41V (c.121A > G), and p.M41L (c.121A > C) in codon 41 of exon 3. Currently, sanger sequencing w
Externí odkaz:
https://doaj.org/article/55be90e427ac44f48e6372b61c46eb9d
Autor:
Aoya Han, Tingting Peng, Yinyin Xie, Wanwan Zhang, Wenlin Sun, Yi Xie, Yunqing Ma, Cui Wang, Nanchang Xie
Publikováno v:
Frontiers in Immunology, Vol 14 (2023)
Regulatory T cells (Tregs) can eliminate autoreactive lymphocytes, induce self-tolerance, and suppress the inflammatory response. Mitochondria, as the energy factories of cells, are essential for regulating the survival, differentiation, and function
Externí odkaz:
https://doaj.org/article/05fff00ac84541ed92ea17371d91774a
Publikováno v:
Cell Reports, Vol 42, Iss 11, Pp 113340- (2023)
Summary: Duchenne muscular dystrophy (DMD) is a severe genetic disease caused by the loss of the dystrophin protein. Exon skipping is a promising strategy to treat DMD by restoring truncated dystrophin. Here, we demonstrate that base editors (e.g., t
Externí odkaz:
https://doaj.org/article/2fe7b5a79f5e4229a373ca11356f9913
Publikováno v:
Bioactive Materials, Vol 10, Iss , Pp 79-92 (2022)
Immune-mediated inflammatory diseases (IMIDs) represent a diverse group of diseases and challenges remain for the current medications. Herein, we present an activatable and targeted nanosystem for detecting and imaging IMIDs foci and treating them th
Externí odkaz:
https://doaj.org/article/3a1280ad6a4b49459f3444cd6b3e4fab
Autor:
Shiji Huo, Jiling Ren, Yunqing Ma, Ahsawle Ozathaley, Wenjian Yuan, Hong Ni, Dong Li, Zhaowei Liu
Publikováno v:
Journal of Neuroinflammation, Vol 18, Iss 1, Pp 1-19 (2021)
Abstract Background Members of the transient receptor potential canonical (TRPC) protein family are widely distributed in the hippocampus of mammals and exert respective and cooperative influences on the functions of neurons. The relationship between
Externí odkaz:
https://doaj.org/article/3a2698c7b5324d8e826c504e5844af29
Publikováno v:
Translational Psychiatry, Vol 11, Iss 1, Pp 1-11 (2021)
Abstract Axonal dystrophy is a swollen and tortuous neuronal process that contributes to synaptic alterations occurring in Alzheimer’s disease (AD). Previous study identified that brain-derived neurotrophic factor (BDNF) binds to tropomyosin-relate
Externí odkaz:
https://doaj.org/article/039b15565ea540149328197d2f9839f3
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 24, Iss , Pp 822-831 (2021)
Mitochondrial dysfunction is an early feature of Alzheimer’s disease (AD), whereby accumulation of damaged mitochondria in conjunction with impaired mitophagy contributes to neurodegeneration. Various non-transcribed microRNAs (miRNAs) are involved
Externí odkaz:
https://doaj.org/article/6caf01773f364fd8bef187cd47a58e62
Publikováno v:
Journal of Orthopaedic Surgery, Vol 30 (2022)
Background China has neither a nationwide joint replacement registry similar to Sweden and New Zealand nor a universal healthcare (medical insurance) registry similar to Hong Kong and Singapore to check. The purpose was to initially understand the di
Externí odkaz:
https://doaj.org/article/d68767060b774197911d9ac68014474f
Publikováno v:
Journal of Orthopaedic Surgery and Research, Vol 15, Iss 1, Pp 1-6 (2020)
Abstract Background Acetabular orientation changes after periacetabular osteotomy (PAO) lead to technical change when performing subsequent total hip arthroplasty (THA). There is no unified consensus regarding the solution for acetabular component in
Externí odkaz:
https://doaj.org/article/fdc9955c192245d7a02703e7d5e17346
Publikováno v:
STAR Protocols, Vol 1, Iss 1, Pp 100005- (2020)
Summary: This protocol uses lipofectamine to deliver base editors (i.e., dCas9 and AIDx fusion protein) and sgRNA expression vectors into Duchenne Muscular Dystrophy (DMD) patient-derived human induced pluripotent stem cells (hiPSCs). This protocol d
Externí odkaz:
https://doaj.org/article/dc4079a4080c414794355153f13184af