Výsledky vyhledávání - "Yunpei Zhang"

Akademický článek

Pericytes control vascular stability and auditory spiral ganglion neuron survival

Autor: Yunpei Zhang, Lingling Neng, Kushal Sharma, Zhiqiang Hou, Anatasiya Johnson, Junha Song, Alain Dabdoub, Xiaorui Shi

Publikováno v: eLife, Vol 12 (2023)

The inner ear has a rich population of pericytes, a multi-functional mural cell essential for sensory hair cell heath and normal hearing. However, the mechanics of how pericytes contribute to the homeostasis of the auditory vascular-neuronal complex

Externí odkaz: https://doaj.org/article/6e30916b1b9a4fa19f1070a9e3368bcd

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Akademický článek

The Emerging Role of Pericyte-Derived Extracellular Vesicles in Vascular and Neurological Health

Autor: Kushal Sharma, Yunpei Zhang, Keshav Raj Paudel, Allan Kachelmeier, Philip M. Hansbro, Xiaorui Shi

Publikováno v: Cells, Vol 11, Iss 19, p 3108 (2022)

Pericytes (PCs), as a central component of the neurovascular unit, contribute to the regenerative potential of the central nervous system (CNS) and peripheral nervous system (PNS) by virtue of their role in blood flow regulation, angiogenesis, mainte

Externí odkaz: https://doaj.org/article/7b8e7f77e9d448809d39e2011eb5ca7e

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Akademický článek

VEGFA165 gene therapy ameliorates blood-labyrinth barrier breakdown and hearing loss

Autor: Jinhui Zhang, Zhiqiang Hou, Xiaohan Wang, Han Jiang, Lingling Neng, Yunpei Zhang, Qing Yu, George Burwood, Junha Song, Manfred Auer, Anders Fridberger, Michael Hoa, Xiaorui Shi

Publikováno v: JCI Insight, Vol 6, Iss 8 (2021)

Millions of people are affected by hearing loss. Hearing loss is frequently caused by noise or aging and often associated with loss of pericytes. Pericytes populate the small vessels in the adult cochlea. However, their role in different types of hea

Externí odkaz: https://doaj.org/article/1933b05f528b49fbad36d9b0be81d8a8

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Akademický článek

Big Data-Based Boring Indexes and Their Application during TBM Tunneling

Autor: Shuangjing Wang, Yujie Wang, Xu Li, Lipeng Liu, Hai Xing, Yunpei Zhang

Publikováno v: Advances in Civil Engineering, Vol 2021 (2021)

Tunnel boring machine (TBM) tunneling data have been extensively collected to utilize TBM information technology by analyzing and mining the data for achieving a safe and efficient TBM tunneling. Feature extraction of big data could reduce the comple

Externí odkaz: https://doaj.org/article/d504d734bb5441f4ab36d9df60f029f2

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Akademický článek

Suppression of Connexin 43 Leads to Strial Vascular Hyper-Permeability, Decrease in Endocochlear Potential, and Mild Hearing Loss

Autor: Jinhui Zhang, Xiaohan Wang, Zhiqiang Hou, Lingling Neng, Jing Cai, Yunpei Zhang, Xiaorui Shi

Publikováno v: Frontiers in Physiology, Vol 11 (2020)

Objective: Connexin 43 (Cx43) is a protein constituent of gap junctions (GJs) in various barrier cells, especially astrocytes and microglia of the blood-brain-barrier (BBB), where it plays an important role in intercellular communication and regulati

Externí odkaz: https://doaj.org/article/6aa21acc68e84c8a9ded808a15393cd6

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Akademický článek

Miconazole protects blood vessels from MMP9-dependent rupture and hemorrhage

Autor: Ran Yang, Yunpei Zhang, Dandan Huang, Xiao Luo, Liangren Zhang, Xiaojun Zhu, Xiaolin Zhang, Zhenming Liu, Jing-Yan Han, Jing-Wei Xiong

Publikováno v: Disease Models & Mechanisms, Vol 10, Iss 3, Pp 337-348 (2017)

Hemorrhagic stroke accounts for 10-15% of all strokes and is strongly associated with mortality and morbidity worldwide, but its prevention and therapeutic interventions remain a major challenge. Here, we report the identification of miconazole as a

Externí odkaz: https://doaj.org/article/c2da6e85dc7542078e23da0bcb657270

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