Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Yunike Akasaka"'
Autor:
Shuhei Kanagaki, Yusuke Tsutsui, Naoki Kobayashi, Takashi Komine, Minoru Ito, Yunike Akasaka, Michiaki Nagasawa, Tomohiro Ide, Naoki Omae, Kazuhisa Nakao, Makoto Rembutsu, Maki Iwago, Aki Yonezawa, Yusei Hosokawa, Tetsuya Hosooka, Wataru Ogawa, Koji Murakami
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106293- (2023)
Summary: 5′-Adenosine monophosphate-activated protein kinase (AMPK) is a potential therapeutic target for various medical conditions. We here identify a small-molecule compound (RX-375) that activates AMPK and inhibits fatty acid synthesis in cultu
Externí odkaz:
https://doaj.org/article/a92b50733fa44d83b46f3299ab983040
Autor:
Minoru Ito, Michiaki Nagasawa, Naoki Omae, Masaki Tsunoda, Junichi Ishiyama, Tomohiro Ide, Yunike Akasaka, Koji Murakami
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 6, Pp 1531-1540 (2013)
Insulin plays important roles in apoptosis and lipid droplet (LD) formation, and it is one of the determinants involved in increasing fat mass. However, the mechanisms underlying insulin-induced enlargement of fat mass remain unclear. Our previous st
Externí odkaz:
https://doaj.org/article/bcf99b2cc6744823b0f6b09daacc0bdf
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 8, Pp 1450-1460 (2011)
Both insulin and the cell death-inducing DNA fragmentation factor-α-like effector (CIDE) family play important roles in apoptosis and lipid droplet formation. Previously, we reported that CIDEA and CIDEC are differentially regulated by insulin and c
Externí odkaz:
https://doaj.org/article/173cca9c863f493591cda16ac4d39ce4
Unsaturated FAs prevent palmitate-induced LOX-1 induction via inhibition of ER stress in macrophages
Autor:
Junichi Ishiyama, Ryoko Taguchi, Yunike Akasaka, Saiko Shibata, Minoru Ito, Michiaki Nagasawa, Koji Murakami
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 2, Pp 299-307 (2011)
Palmitic acid (PA) upregulates oxidized LDL receptor-1 (LOX-1), a scavenger receptor responsible for uptake of oxidized LDL (oxLDL), and enhances oxLDL uptake in macrophages. However, the precise underlying mechanism remains to be elucidated. PA is k
Externí odkaz:
https://doaj.org/article/47b4374b2ffe48e289257e55509725a7
Autor:
Koji Murakami, Junichi Ishiyama, Minoru Ito, Tomohiro Ide, Naoki Omae, Masaki Tsunoda, Michiaki Nagasawa, Yunike Akasaka
Publikováno v:
Journal of Lipid Research, Vol 54, Iss 6, Pp 1531-1540 (2013)
Insulin plays important roles in apoptosis and lipid droplet (LD) formation, and it is one of the determinants involved in increasing fat mass. However, the mechanisms underlying insulin-induced enlargement of fat mass remain unclear. Our previous st
Unsaturated FAs prevent palmitate-induced LOX-1 induction via inhibition of ER stress in macrophages
Autor:
Yunike Akasaka, Saiko Shibata, Minoru Ito, Michiaki Nagasawa, Koji Murakami, Ryoko Taguchi, Junichi Ishiyama
Publikováno v:
Journal of Lipid Research, Vol 52, Iss 2, Pp 299-307 (2011)
Journal of Lipid Research
Journal of Lipid Research
Palmitic acid (PA) upregulates oxidized LDL receptor-1 (LOX-1), a scavenger receptor responsible for uptake of oxidized LDL (oxLDL), and enhances oxLDL uptake in macrophages. However, the precise underlying mechanism remains to be elucidated. PA is k
Publikováno v:
Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids. 1801:1115-1122
Leptin administration has been shown to enhance muscle lipid oxidation in relation to the energy expenditure. Both long-form (Ob-R(L)) and short-form leptin receptors (Ob-R(S)) are expressed in skeletal muscle, but the role of Ob-R(S) is unclear. In
Publikováno v:
Biochemical Pharmacology. 78:523-530
Peroxisome proliferator-activated receptor-alpha (PPARalpha) is a key regulator in hepatic lipid metabolism and is a potential therapeutic target for dyslipidaemia. We reported previously that human hepatic apoA-IV is a highly sensitive gene up-regul
Publikováno v:
Biochimica et biophysica acta. 1791(2)
Leptin administration enhances lipid oxidation in skeletal muscle. Nevertheless, direct and chronic effect of leptin has not been well characterized. Here, we measured the effect of leptin on skeletal muscles and their signaling pathways using differ
Autor:
Koji Murakami, Michiaki Nagasawa, Tomoko Hara, Tomohiro Ide, Naoki Kobayashi, Mari Utsumi, Yunike Akasaka
Publikováno v:
Biochemical pharmacology. 74(12)
Peroxisome proliferator-activated receptor alpha (PPARalpha) is a key regulator in hepatic lipid metabolism and a potential therapeutic target for dyslipidemia. However, in humans hepatic PPARalpha-regulated genes remain unclear. To investigate the e