Zobrazeno 1 - 10
of 25
pro vyhledávání: '"Yuniel Fernández-Marrero"'
Autor:
Živa Frangež, Deborah Gérard, Zhaoyue He, Marios Gavriil, Yuniel Fernández-Marrero, S. Morteza Seyed Jafari, Robert E. Hunger, Philippe Lucarelli, Shida Yousefi, Thomas Sauter, Lasse Sinkkonen, Hans-Uwe Simon
Publikováno v:
Frontiers in Oncology, Vol 11 (2021)
Autophagy is a highly conserved cellular process in which intracellular proteins and organelles are sequestered and degraded after the fusion of double-membrane vesicles known as autophagosomes with lysosomes. The process of autophagy is dependent on
Externí odkaz:
https://doaj.org/article/92f2f53d26a24de8bac3faed30cc5478
Autor:
Francine Ke, Jason Glab, Andrew H. Wei, Tao G. Nelson, Samara Naim, Christina Nedeva, Suresh Mathivanan, Hamsa Puthalakath, Lorraine A. O'Reilly, Cody C. Allison, Robert G. Ramsay, Fiona C. Brown, Marcel Doerflinger, Brian J. Smith, Daniel Bachmann, Joseph Menassa, Rahul Srivastava, Yuniel Fernández-Marrero, Lahiru Gangoda, Sanjay Shahi, Andrew J. Kueh, Tatiana Rabachini, Zhipeng Cao, Thomas Kaufmann, Laura D. Osellame
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
Significance It is believed that the Bcl-2 family protein Bok has a redundant role similar to Bax and Bak in regulating apoptosis. We report that this protein interacts with the key enzyme involved in uridine biosynthesis, uridine monophosphate synth
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c94d8ec59a137e8d6b83349b667f53d4
Autor:
Robert E. Hunger, S. Morteza Seyed Jafari, Valentin Djonov, Yuniel Fernández-Marrero, Darko Stojkov, Carsten Riether, Živa Frangež, Hans-Uwe Simon
Publikováno v:
Oncogene. 39(26)
Endophilin B1, also known as BAX-interacting protein 1 (BIF-1), is part of the endophilin B protein family, and is a multifunctional protein involved in the regulation of apoptosis, autophagy, and mitochondrial morphology. The role of BIF-1 in cancer
Autor:
Giulio Loforese, Tatiana Rabachini, Simone Wicki, Thomas Kaufmann, Deborah Stroka, Zhaoyue He, Valentina C. Sladky, Andreas Villunger, Yuniel Fernández-Marrero, Daniel Bachmann, Matteo Montani
Publikováno v:
Rabachini de Almeida, Tatiana; Fernández Marrero, Yuniel; Montani, Matteo; Loforese, Giulio; Sladky, Valentina; He, Zhaoyue; Bachmann, Daniel; Wicki, Simone; Villunger, Andreas; Keogh-Stroka, Deborah M.; Kaufmann, Thomas (2018). BOK promotes chemical-induced hepatocarcinogenesis in mice. Cell death and differentiation, 25(4), pp. 706-718. Nature Publishing Group 10.1038/s41418-017-0008-0
BCL-2-related ovarian killer (BOK) is a conserved and widely expressed BCL-2 family member with sequence homology to pro-apoptotic BAX and BAK, but with poorly understood pathophysiological function. Since several members of the BCL-2 family are crit
Autor:
Narjara Gonzalez Suarez, Yuniel Fernandez-Marrero, Mathieu P. A. Hébert, Marie-Eve Roy, Luc H. Boudreau, Borhane Annabi
Publikováno v:
Cancer Cell International, Vol 23, Iss 1, Pp 1-21 (2023)
Abstract Background Triple-negative breast cancer (TNBC) cells’ secretome can induce a pro-inflammatory phenotype in human adipose-derived mesenchymal stem cells (hADMSC). This can be prevented by the green tea polyphenol epigallocatechin-3-gallate
Externí odkaz:
https://doaj.org/article/894527d53da14376b871eeea5f6fc51e
Autor:
Kamila Benkova, Albert D. Donnenberg, Yuniel Fernández-Marrero, Erika Moravcikova, Vera S. Donnenberg, Tatiana Rabachini, Thomas Kaufmann, Evzen Krepela, Daniel Bachmann
Publikováno v:
International Journal of Cancer. 141:2050-2061
Since the genomic region containing the Bcl-2-related ovarian killer (BOK) locus is frequently deleted in certain human cancers, BOK is hypothesized to have a tumor suppressor function. In the present study, we analyzed primary non-small cell lung ca
Publikováno v:
Leukemia
Programmed apoptotic cell death is critical to maintain tissue homeostasis and cellular integrity in the lymphatic system. Accordingly, the evasion of apoptosis is a critical milestone for the transformation of lymphocytes on their way to becoming ov
Autor:
Daniel Bachmann, Kushal Kumar Das, Yuniel Fernández-Marrero, Ana J. García-Sáez, Stephanie Bleicken, Thomas Kaufmann
Publikováno v:
The FEBS journal
Fernandez-Marrero, Yuniel; Bleicken, Stephanie; Das, Kushal Kumar; Bachmann, Daniel; Kaufmann, Thomas; Garcia-Saez, Ana J (2017). The membrane activity of BOK involves formation of large, stable toroidal pores and is promoted by cBID. FEBS journal, 284(5), pp. 711-724. Wiley-Blackwell 10.1111/febs.14008
Fernandez-Marrero, Yuniel; Bleicken, Stephanie; Das, Kushal Kumar; Bachmann, Daniel; Kaufmann, Thomas; Garcia-Saez, Ana J (2017). The membrane activity of BOK involves formation of large, stable toroidal pores and is promoted by cBID. FEBS journal, 284(5), pp. 711-724. Wiley-Blackwell 10.1111/febs.14008
The BCL 2 family members are key regulators of the intrinsic apoptotic pathway which is defined by permeabilisation of the mitochondrial outer membrane by members of the BAX like subfamily. BOK is classified as a BAX like protein; however its (patho
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::393ff14658ea933149bb0d08dbff7db5
Autor:
Francine Ke, Philippe Bouillet, Nohemy Echeverry, Yuniel Fernández-Marrero, Thomas Kaufmann, Daniel Bachmann, Andreas Strasser
Publikováno v:
Proceedings of the National Academy of Sciences of the United States of America
The B-cell lymphoma 2 (BCL-2)-related ovarian killer (BOK) shares sequence homology with the proapoptotic BCL-2 family members BAX and BAK. However, Bok −/− cells are not protected from classic apoptotic triggers and evidence for a proapoptotic r
Autor:
Yosdel Soto, Emilio Acosta, Livan Delgado, Angela Fraga, Alejandro López-Requena, Ana María Vázquez, Arlenis Pérez, M. Noa, Yuniel Fernández-Marrero, Tania Griñán, Eduardo Fernández, Viviana Falcón, Victor Brito, Maria A. Bécquer, Irene Alvarez
Publikováno v:
Arteriosclerosis, Thrombosis, and Vascular Biology. 32:595-604
Objective— Subendothelial retention of proatherogenic lipoproteins by proteoglycans is critical in atherosclerosis. The aim of this study was to characterize the recognition and antiatherogenic properties of a chimeric monoclonal antibody (mAb) tha