Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Yunhui Lang"'
Autor:
Tak W. Mak, Xin Wei, Guodong Mao, Grace Ng, Richard Brokx, Dan Chi-Chia Lin, Graham C. Fletcher, Miklos Feher, Olga Plotnikova, Richard J. Hodgson, Radoslaw Laufer, Henry W. Pauls, Jacqueline M. Mason, Yunhui Lang, Brian Madeira, Irina Beletskaya, Sze-Wan Li, Yong Liu, Yi Che, Donald E. Awrey, Reza Kiarash, Mark R. Bray
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 26:3562-3566
TTK/Mps1 is a key kinase controlling progression of cell division via participation in the mitotic spindle assembly checkpoint and is overexpressed in a number of human cancers. Herein we report the discovery of 4-(4-aminopyrazolo[1,5-a][1,3,5]triazi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ba09af33425cf05a065bc4b1c08a55bc
https://doi.org/10.1016/j.bmcl.2016.06.021
https://doi.org/10.1016/j.bmcl.2016.06.021
Autor:
Mark R. Bray, Wei Qiu, Radoslaw Laufer, Olga Plotnikova, Henry W. Pauls, Richard Brokx, Dan Chi-Chia Lin, Graham C. Fletcher, Richard J. Hodgson, Sze-Wan Li, Narendra Kumar B. Patel, Peter Brent Sampson, Jacqueline M. Mason, Irina Beletskaya, Yunhui Lang, Xin Wei, Yi Che, Reza Kiarash, Tak W. Mak, Miklos Feher, Grace Ng, Donald E. Awrey, Yong Liu, Nickolay Y. Chirgadze
Publikováno v:
ACS Medicinal Chemistry Letters. 7:671-675
This work describes a scaffold hopping exercise that begins with known imidazo[1,2-a]pyrazines, briefly explores pyrazolo[1,5-a][1,3,5]triazines, and ultimately yields pyrazolo[1,5-a]pyrimidines as a novel class of potent TTK inhibitors. An X-ray str
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b3996eda3d4b7410ff16b6aa6d5433d5
https://doi.org/10.1021/acsmedchemlett.5b00485
https://doi.org/10.1021/acsmedchemlett.5b00485
Autor:
Fuqiang Ban, Dan Chi-Chia Lin, Erin Green, Sze-Wan Li, Guohua J. Pan, Richard J. Hodgson, Miklos Feher, Yong Liu, Wei Qiu, Olga Plotnikova, Narendra Kumar B. Patel, Grace Ng, Marees Harris-Brandts, Guodong Mao, Nickolay Y. Chirgadze, Don E. Awrey, Irina Beletskaya, Henry W. Pauls, Yunhui Lang, Ping Huang, Vincent Nadeem, Xin Wei, Tak W. Mak, Genie Leung, Reza Kiarash, Jacqueline M. Mason, Louise Edwards, Radoslaw Laufer, Xunyi Luo
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:4968-4997
TTK kinase was identified by in-house siRNA screen and pursued as a tractable, novel target for cancer treatment. A screening campaign and systematic optimization, supported by computer modeling led to an indazole core with key sulfamoylphenyl and ac
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c63402e43dae5221f6ff6a1f83b914c
https://doi.org/10.1016/j.bmc.2014.06.027
https://doi.org/10.1016/j.bmc.2014.06.027
Autor:
Yunhui Lang, Louise Edwards, Radoslaw Laufer, Yi Che, Dan Chi-Chia Lin, Yong Liu, Bryan T. Forrest, Sze-Wan Li, Mark R. Bray, Tak W. Mak, Narendra Kumar B. Patel, Xin Wei, Henry W. Pauls, Nickolay Y. Chirgadze, Reza Kiarash, Wei Qiu, Olga Plotnikova, Brian Madeira, Graham C. Fletcher, Richard J. Hodgson, Fuqiang Ban, Miklos Feher, Guodong Mao, Grace Ng, Irina Beletskaya, Donald E. Awrey, Jacqueline M. Mason, Peter Brent Sampson
Publikováno v:
Journal of medicinal chemistry. 58(8)
The acetamido and carboxamido substituted 3-(1H-indazol-3-yl)benzenesulfonamides are potent TTK inhibitors. However, they display modest ability to attenuate cancer cell growth; their physicochemical properties, and attendant pharmacokinetic paramete
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a417f7f080d3add29660da28a0bca0d4
https://pubmed.ncbi.nlm.nih.gov/25763473
https://pubmed.ncbi.nlm.nih.gov/25763473
Autor:
Peter B. Sampson, Yong Liu, Narendra Kumar Patel, Miklos Feher, Bryan Forrest, Sze-Wan Li, Louise Edwards, Radoslaw Laufer, Yunhui Lang, Fuqiang Ban, Donald E. Awrey, Guodong Mao, Olga Plotnikova, Genie Leung, Richard Hodgson, Jacqueline Mason, Xin Wei, Reza Kiarash, Erin Green, Wei Qiu, Nickolay Y. Chirgadze, Tak W. Mak, Guohua Pan, Henry W. Pauls
Publikováno v:
Journal of medicinal chemistry. 58(1)
Polo-like kinase 4 (PLK4), a unique member of the polo-like kinase family of serine-threonine kinases, is a master regulator of centriole duplication that is important for maintaining genome integrity. Overexpression of PLK4 is found in several human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1db45474216f629dfe05ee2b429ad8b7
https://pubmed.ncbi.nlm.nih.gov/24867403
https://pubmed.ncbi.nlm.nih.gov/24867403
Autor:
Miklos Feher, Yi Yao, Guodong Mao, Yong Liu, Peter Brent Sampson, Fuqiang Ban, Reza Kiarash, Bryan T. Forrest, Guohua Pan, Louise Edwards, Irina Beletskaya, Radoslaw Laufer, Sze-Wan Li, Erin Green, Xin Wei, Yunhui Lang, Henry W. Pauls, Donald E. Awrey, Tak W. Mak, Genie Leung, Xunyi Luo, Olga Plotnikova, Richard J. Hodgson, Jacqueline M. Mason
Publikováno v:
Journal of medicinal chemistry. 56(15)
The family of Polo-like kinases is important in the regulation of mitotic progression; this work keys on one member, namely Polo-like kinase 4 (PLK4). PLK4 has been identified as a candidate anticancer target which prompted a search for potent and se
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c3fed019457cec42d3cd51dda83dfcf2
https://pubmed.ncbi.nlm.nih.gov/23829549
https://pubmed.ncbi.nlm.nih.gov/23829549
Autor:
Nicholas J. Taylor, Yunhui Lang, Russell Rodrigo, Fabio E. S. Souza, Xinshe Xu, Abdeljalil Assoud
Publikováno v:
The Journal of organic chemistry. 74(15)
A regiocontrolled intermolecular Diels-Alder reaction of an o-benzoquinone followed by an intramolecular nitrile oxide cyclization is employed to prepare the BCD fragment of viridin. The AE segment is attached to it by means of an intramolecular Diel
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::61860f8bdff45c55b56cc6d1229f4141
https://pubmed.ncbi.nlm.nih.gov/19572524
https://pubmed.ncbi.nlm.nih.gov/19572524
Autor:
Vincent Nadeem, Reza Kiarash, Peter Brent Sampson, Sam Wei, Radek Laufer, Irina Beletskaya, Henry W. Pauls, Jacqueline M. Mason, Sze-Wan Li, Xunyi Luo, Miklos Feher, Yong Liu, Bryan T. Forrest, Genie Leung, James Guohua Pan, Don Awrey, Yunhui Lang, Tak W. Mak, Ping Huang
Publikováno v:
Cancer Research. 71:LB-215
Polo-like kinase 4 or PLK4 is a member of a conserved family of serine/threonine protein kinases that regulate multiple cellular processes, such as cell division and checkpoint regulation of mitosis. These kinases are often deregulated in cancer. PLK
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::7350b1cd6e66c1170f0e83c853224924
https://doi.org/10.1158/1538-7445.am2011-lb-215
https://doi.org/10.1158/1538-7445.am2011-lb-215
Autor:
Yong Liu, Yunhui Lang, Patel, Narendra Kumar, Ng, Grace, Laufer, Radoslaw, Sze-Wan Li, Edwards, Louise, Forrest, Bryan, Sampson, Peter B., Feher, Miklos, Ban, Fuqiang, Awrey, Donald E., Beletskaya, Irina, Mao, Guodong, Hodgson, Richard, Plotnikova, Olga, Qiu, Wei, Chirgadze, Nickolay Y., Mason, Jacqueline M., Wei, Xin
Publikováno v:
Journal of Medicinal Chemistry; Apr2015, Vol. 58 Issue 8, p3366-3392, 27p