Zobrazeno 1 - 10
of 165
pro vyhledávání: '"Yunhua Chang"'
Autor:
Yao Xiang, Jorge Mata-Garrido, Yuanji Fu, Christophe Desterke, Eric Batsché, Ahmed Hamaï, Christine Sedlik, Youssouf Sereme, David Skurnik, Abdelali Jalil, Rachel Onifarasoaniaina, Eric Frapy, Jean-Christophe Beche, Razack Alao, Eliane Piaggio, Laurence Arbibe, Yunhua Chang
Publikováno v:
EMBO Molecular Medicine, Vol 16, Iss 6, Pp 1404-1426 (2024)
Abstract As an important immune stimulator and modulator, IFNγ is crucial for gut homeostasis and its dysregulation links to diverse colon pathologies, such as colitis and colorectal cancer (CRC). Here, we demonstrated that the epigenetic regulator,
Externí odkaz:
https://doaj.org/article/de2e44b1297c4b6381469b61856d34e2
Autor:
Youssouf Sereme, Cécile Schrimp, Helène Faury, Maeva Agapoff, Esther Lefebvre-Wloszczowski, Yunhua Chang Marchand, Elisabeth Ageron-Ardila, Emilie Panafieu, Frank Blec, Mathieu Coureuil, Eric Frapy, Vassilis Tsatsaris, Stephane Bonacorsi, David Skurnik
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-16 (2024)
Abstract Preterm birth is currently the leading cause of neonatal morbidity and mortality. Genetic, immunological and infectious causes are suspected. Preterm infants have a higher risk of severe bacterial neonatal infections, most of which are cause
Externí odkaz:
https://doaj.org/article/053d057a538d4c10b429a98402ff8f27
Autor:
Emma Cosialls, Emeline Pacreau, Clémence Duruel, Sara Ceccacci, Rima Elhage, Christophe Desterke, Kevin Roger, Chiara Guerrera, Romane Ducloux, Sylvie Souquere, Gérard Pierron, Ivan Nemazanyy, Mairead Kelly, Elise Dalmas, Yunhua Chang, Vincent Goffin, Maryam Mehrpour, Ahmed Hamaï
Publikováno v:
Cell Death and Disease, Vol 14, Iss 11, Pp 1-14 (2023)
Abstract Ferroptosis constitutes a promising therapeutic strategy against cancer by efficiently targeting the highly tumorigenic and treatment-resistant cancer stem cells (CSCs). We previously showed that the lysosomal iron-targeting drug Salinomycin
Externí odkaz:
https://doaj.org/article/5ad5e737bb114cf494300de72b4fe890
Autor:
Jorge Mata-Garrido, Yao Xiang, Yunhua Chang-Marchand, Caroline Reisacher, Elisabeth Ageron, Ida Chiara Guerrera, Iñigo Casafont, Aurelia Bruneau, Claire Cherbuy, Xavier Treton, Anne Dumay, Eric Ogier-Denis, Eric Batsché, Mickael Costallat, Gwladys Revêchon, Maria Eriksson, Christian Muchardt, Laurence Arbibe
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-16 (2022)
This study reports reduced expression of the chromatin and splicing regulator HP1γ in inflammatory bowel disease (IBD) and shows that HP1γ protects against pervasive RNA splicing leading to toxic mRNA products detected in IBD, like progerin.
Externí odkaz:
https://doaj.org/article/cd62808a02c4443c8de8c01333a7ee93
Autor:
Christophe Desterke, Emma Cosialls, Yao Xiang, Rima Elhage, Clémence Duruel, Yunhua Chang, Ahmed Hamaï
Publikováno v:
Cells, Vol 12, Iss 17, p 2176 (2023)
(1) Background: Breast cancer is a frequent heterogeneous disorder diagnosed in women and causes a high number of mortality among this population due to rapid metastasis and disease recurrence. Ferroptosis can inhibit breast cancer cell growth, impro
Externí odkaz:
https://doaj.org/article/f4e952652b864e7d82ef70cc4b125d7d
Autor:
Jorge Mata-Garrido, Laura Frizzi, Thien Nguyen, Xiangyan He, Yunhua Chang-Marchand, Yao Xiang, Caroline Reisacher, Iñigo Casafont, Laurence Arbibe
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 8, p 7347 (2023)
Chronic inflammatory processes in the intestine result in serious conditions such as inflammatory bowel disease (IBD) and cancer. An increased detection of cytoplasmic DNA sensors has been reported in the IBD colon mucosa, suggesting their contributi
Externí odkaz:
https://doaj.org/article/af20f9fa78fd4eaca5993a9c6bca71c4
Improving Intra-Urban Prediction of Atmospheric Fine Particles Using a Hybrid Deep Learning Approach
Publikováno v:
Atmosphere, Vol 14, Iss 3, p 599 (2023)
Growing evidence links intra-urban gradients in atmospheric fine particles (PM2.5), a complex and variable cocktail of toxic chemicals, to adverse health outcomes. Here, we propose an improved hierarchical deep learning model framework to estimate th
Externí odkaz:
https://doaj.org/article/6a7f720b20c6403b9f88e84cea51cf5b
Autor:
Sandrine Dulong, Lucas Eduardo Botelho de Souza, Jean Machowiak, Benoit Peuteman, Gaelle Duvallet, Déborah Boyenval, Elise Roth, Afag Asgarova, Yunhua Chang, Xiao-Mei Li, Adlen Foudi, Annabelle Ballesta
Publikováno v:
Pharmaceutics, Vol 14, Iss 11, p 2465 (2022)
Oxaliplatin was nearly twice as hematotoxic, with optimal circadian timing differing by 6 h, in women as compared to men with colorectal cancers. Hence, we investigated sex- and timing-related determinants of oxaliplatin hematopoietic toxicities in m
Externí odkaz:
https://doaj.org/article/4eb1871dcdec473f9e2220ee8b078af6
Autor:
Yuan Zhang, Aurore Devocelle, Christophe Desterke, Lucas Eduardo Botelho de Souza, Éva Hadadi, Hervé Acloque, Adlen Foudi, Yao Xiang, Annabelle Ballesta, Yunhua Chang, Julien Giron-Michel
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 10, p 5247 (2021)
The circadian clock coordinates biological and physiological functions to day/night cycles. The perturbation of the circadian clock increases cancer risk and affects cancer progression. Here, we studied how BMAL1 knockdown (BMAL1-KD) by shRNA affects
Externí odkaz:
https://doaj.org/article/3f128e668b7944249a70decc281ffa0c
Publikováno v:
PLoS ONE, Vol 10, Iss 12, p e0144661 (2015)
Although human excreta as a NH3 source has been recognized globally, this source has never been quantitatively determined in cities, hampering efforts to fully assess the causes of urban air pollution. In the present study, the exhausts of 15 ceiling
Externí odkaz:
https://doaj.org/article/c9e3cb46ebf94410811ea837161bda99