Activation of coagulation FXI promotes endothelial inflammation and amplifies platelet activation in a nonhuman primate model of hyperlipidemia.

Autor: Kohs TCL; Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA., Vu HH; Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA., Jordan KR; Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA., Parra-Izquierdo I; Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA., Hinds MT; Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA., Shatzel JJ; Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA.; Division of Hematology and Oncology, Oregon Health & Science University, Portland, Oregon, USA., Kievit P; Division of Cardiometabolic Health, Oregon National Primate Research Center, Oregon Health & Science University, Beaverton, Oregon, USA., Morgan TK; Department of Pathology and Laboratory Medicine, Oregon Health & Science University, Portland, Oregon, USA., Yunga ST; Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA.; Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA., Ngo TTM; Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA.; Cancer Early Detection Advanced Research Center, Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon, USA.; Department of Molecular and Medical Genetics, Oregon Health & Science University, Portland, Oregon, USA., Aslan JE; Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA.; Knight Cardiovascular Institute, School of Medicine, Oregon Health & Science University, Portland, Oregon, USA.; Department of Chemical Physiology and Biochemistry, Oregon Health & Science University, Portland, Oregon, USA., Wallisch M; Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA.; Aronora, Inc, Portland, Oregon, USA., Lorentz CU; Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA.; Aronora, Inc, Portland, Oregon, USA., Tucker EI; Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA.; Aronora, Inc, Portland, Oregon, USA., Gailani D; Department of Pathology, Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA., Lindner JR; Division of Cardiovascular Medicine and Robert M. Berne Cardiovascular Research Institute, University of Virginia, Charlottesville, Virginia, USA., Puy C; Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA., McCarty OJT; Department of Biomedical Engineering, Oregon Health & Science University, Portland, Oregon, USA.; Division of Hematology and Oncology, Oregon Health & Science University, Portland, Oregon, USA.

Publikováno v: Research and practice in thrombosis and haemostasis [Res Pract Thromb Haemost] 2023 Nov 27; Vol. 8 (1), pp. 102276. Date of Electronic Publication: 2023 Nov 27 (Print Publication: 2024).