Zobrazeno 1 - 10 of 15 pro vyhledávání: '"Yung-Mae M. Yao"'
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Mouse PDX Trial Suggests Synergy of Concurrent Inhibition of RAF and EGFR in Colorectal Cancer with BRAF or KRAS Mutations
Autor: Amit Aggarwal, Gregory P. Donoho, Gregory D. Plowman, Ramon V. Tiu, Robert D. Van Horn, Sheng Bin Peng, Youyan Zhang, Jason C. Ting, Ruslan D. Novosiadly, Yue Webster, Yung Mae M. Yao, Amelie Forest, Philip W. Iversen, Henry James Robert, Philip J. Ebert, Steven M. Bray
Publikováno v: Clinical Cancer Research. 23:5547-5560
Purpose: To evaluate the antitumor efficacy of cetuximab in combination with LSN3074753, an analog of LY3009120 and pan-RAF inhibitor in 79 colorectal cancer patient-derived xenograft (PDX) models. Experimental Design: Seventy-nine well-characterized
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b8e91745a7aa1ee85df34176552dc960
https://doi.org/10.1158/1078-0432.ccr-16-3250
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7
Abstract B108: Antitumor efficacy of EGFR antibody necitumumab and dual PI3K/mTOR inhibitor (LY3023414) in preclinical tumor models
Autor: Tod Smeal, Gerald Hall, Gregory P. Donoho, Thompson N. Doman, Philip W. Iversen, Manisha Brahmachary, Yung-mae M. Yao, Michael Kalos, Jason Manro, Xueqian Gong, Xuemei Guo, Sean Buchanan, Ruslan D. Novosiadly, Maxine Melchior
Publikováno v: Molecular Cancer Therapeutics. 17:B108-B108
Necitumumab (Nmab) in combination with chemotherapy has demonstrated overall survival benefit in patients with advanced or metastatic squamous non-small cell lung cancer (SqNSCLC). The PI3K/ mTOR pathway shows aberrant activity in multiple tumor type
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::be095b714e497db0f011df3f884d158e
https://doi.org/10.1158/1535-7163.targ-17-b108
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8
Abstract LB-004: Mouse PDX Trial Suggests Combination Efficacy of Raf and EGFR Inhibition in Colorectal Cancer with BRaf or KRas mutation
Autor: Yue Webster, Yung-mae M. Yao, Yong Gang Yue, Sheng-Bin Peng, Gregory P. Donoho, Philip W. Iversen, Henry James Robert, Gregory D. Plowman
Publikováno v: Cancer Research. 75:LB-004
MAPK activation through KRas, NRas or BRaf mutation occurs in approximately 70% of colorectal cancer patients. Due to their epithelial origin, colorectal tumors generally have high levels of EGFR expression and activation. EGFR therapies such as cetu
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::ae97bd4d8ec2ece03fbb51e3d2d5ce83
https://doi.org/10.1158/1538-7445.am2015-lb-004
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9
Upconverting phosphor reporters in immunochromatographic assays
Autor: William H. Wright, David E. Cooper, J Hampl, D B MacQueen, Yung-Mae M. Yao, N A Mufti, Michael P. Hall
Publikováno v: Analytical biochemistry. 288(2)
Immunochromatographic assays have become popular diagnostic tools in a variety of settings because they are sensitive, fast, and easy to use. Here, we describe the use of a novel reporter, upconverting phosphors (UCP), in this assay format. UCP are s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2c8bd93045c3577c99cb648db771b44b
https://pubmed.ncbi.nlm.nih.gov/11152588
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10
Flow cytometry with upconverting phosphor reporters
Autor: Gary A. Rundle, William H. Wright, David E. Cooper, Naheed A. Mufti, Yung-Mae M. Yao
Publikováno v: SPIE Proceedings.
We report the first demonstration of flow cytometry using upconverting phosphor microsphere reporters. These unique materials are excited by near infrared light from a diode laser and emit visible light in narrow emission bands in the 500 to 700 nm s
Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::0045092b3816cd0d17edffb745d3bb2e
https://doi.org/10.1117/12.307099
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