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Akademický článek

A chalcone derivative SBD-2 exerts anticancer effects in human colorectal cancer cells

Autor: Bowen Zheng, Wanjun Lin, Na Zhang, Xiaoming Huang, Jingjing Du, Yunfu Shen, Junhe Chen, Qianyu Lin, Zhuya Yang, Wenzhe Ma

Publikováno v: Future Journal of Pharmaceutical Sciences, Vol 10, Iss 1, Pp 1-9 (2024)

Abstract Background In this study, the potential anticancer activity and mechanism of action of SBD-2, a chalcone isolated from Shuteria involucrata, was investigated in colorectal cancer (CRC) cells. Results SBD-2 inhibited the proliferation of Caco

Externí odkaz: https://doaj.org/article/96bc78957f6442589b59de5581c1a0de

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Akademický článek

Exploring the pharmacological mechanisms of Shuanghuanglian against T-cell acute lymphoblastic leukaemia through network pharmacology combined with molecular docking and experimental validation

Autor: You Yang, Yan Yang, Yunfu Shen, Jing Liu, Yan Zeng, Chengming Wei, Chunyan Liu, Yansha Pan, Qulian Guo, Fangfang Zhong, Ling Guo, Wenjun Liu

Publikováno v: Pharmaceutical Biology, Vol 61, Iss 1, Pp 259-270 (2023)

AbstractContext Due to the poor prognosis of T-cell acute lymphoblastic leukaemia (T-ALL), there is an urgent need to identify safer and more cost-effective drugs.Objective This study evaluated the antitumour activity of Shuanghuanglian (SHL) on T-AL

Externí odkaz: https://doaj.org/article/0e03ca3dbb55427182d4995d10ad22e8

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Akademický článek

Yinzhihuang injection induces apoptosis and suppresses tumor growth in acute myeloid leukemia cells.

Autor: Zhe Huang, Yunfu Shen, Xianming Fan, Qulian Guo, Wenzhe Ma

Publikováno v: PLoS ONE, Vol 18, Iss 10, p e0289697 (2023)

BackgroundThe unmet needs in treating acute myeloid leukemia(AML) promote us to look for more effective and less toxic therapies. In this study, we discovered that Yinzhihuang injection(YZHI), a traditional Chinese patent medicine for hepatitis treat

Externí odkaz: https://doaj.org/article/81fc8db35d814e0780de68dc2fa7e36e

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Akademický článek

Mitochondrial toxicity evaluation of traditional Chinese medicine injections with a dual in vitro approach

Autor: Yunfu Shen, Kaiqiang Guo, Aijun Ma, Zhe Huang, Jingjing Du, Junhe Chen, Qianyu Lin, Chengming Wei, Zi Wang, Fuming Zhang, Juan Zhang, Wanjun Lin, Na Feng, Wenzhe Ma

Publikováno v: Frontiers in Pharmacology, Vol 13 (2022)

There are technical obstacles in the safety evaluation of traditional Chinese medicine (TCM) injections due to their complex chemical nature and the lack of rapid and accurate in vitro methods. Here, we established a dual in vitro mitochondrial toxic

Externí odkaz: https://doaj.org/article/d4f45b5ababd415481f33424948a7cd9

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