Zobrazeno 1 - 10
of 44
pro vyhledávání: '"Yunfu Lin"'
Autor:
Zaowen Chen, Yunfu Lin, Eveline Barbieri, Sue Burlingame, John Hicks, Andrew Ludwig, Jason M. Shohet
Publikováno v:
Neoplasia: An International Journal for Oncology Research, Vol 11, Iss 8, Pp 753-762 (2009)
Neuroblastoma is derived from neural crest precursor components of the peripheral sympathetic nervous system and accounts for more than 15% of all pediatric cancer deaths. A clearer understanding of the molecular basis of neuroblastoma is required fo
Externí odkaz:
https://doaj.org/article/81256befa12241f0b4807896ced30b6e
Autor:
Yunfu Lin, John H Wilson
Publikováno v:
PLoS ONE, Vol 7, Iss 10, p e46807 (2012)
Expansion of CAG•CTG tracts located in specific genes is responsible for 13 human neurodegenerative disorders, the pathogenic mechanisms of which are not yet well defined. These disease genes are ubiquitously expressed in human tissues, and transcr
Externí odkaz:
https://doaj.org/article/23f14522f98e463fa1dc188070a6ac08
Publikováno v:
Molecular Biology Reports. 41:5627-5634
Microsatellite sequences, composed of short tandem repeats and randomly distributed in human genome, can become unstable during various DNA metabolic processes. Expansions of CAG, GAA, CGG and CCTG repeats located in specific genes are responsible fo
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::90491bc5d6a26f3ef445f64c76a70a36
https://doi.org/10.1007/s11033-014-3432-y
https://doi.org/10.1007/s11033-014-3432-y
Publikováno v:
DNA Repair. 12:480-487
Double-strand breaks (DSBs), a common type of DNA lesion, occur daily in human cells as a result of both endogenous and exogenous damaging agents. DSBs are repaired in two general ways: by the homology-dependent, error-free pathways of homologous rec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::699ea0d1ee49740ce832c818c06001b6
https://doi.org/10.1016/j.dnarep.2013.04.024
https://doi.org/10.1016/j.dnarep.2013.04.024
Publikováno v:
Postdoc Journal. 4
Almost 20 incurable neurodegenerative disorders are caused by trinucleotide repeat (TNR) expansion beyond a certain threshold, with disease time of onset and severity positively correlating with repeat length. Typically, long TNRs display a bias towa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6a8228f5f96ad3e7316ad8b47eda033a
https://doi.org/10.14304/surya.jpr.v4n5.1
https://doi.org/10.14304/surya.jpr.v4n5.1
Publikováno v:
Journal of molecular biology. 428(15)
Multiple pathways modulate the dynamic mutability of trinucleotide repeats (TNRs), which are implicated in neurodegenerative disease and evolution. Recently, we reported that environmental stresses induce TNR mutagenesis via stress responses and rere
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::033ae185a5513b65ff1a222a18b462e8
https://pubmed.ncbi.nlm.nih.gov/27318194
https://pubmed.ncbi.nlm.nih.gov/27318194
Publikováno v:
DNA repair. 42
Trinucleotide repeat (TNR) expansion beyond a certain threshold results in some 20 incurable neurodegenerative disorders where disease anticipation positively correlates with repeat length. Long TNRs typically display a bias toward further expansion
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a7e2f1b39c152c459d863dd19932d6a6
https://pubmed.ncbi.nlm.nih.gov/27131875
https://pubmed.ncbi.nlm.nih.gov/27131875
Autor:
John H. Wilson, Yunfu Lin
Publikováno v:
Cell Cycle. 10:611-618
Trinucleotide repeats (TNRs) are a blessing and a curse. In coding regions, where they are enriched, short repeats offer the potential for continuous, rapid length variation with linked incremental changes in the activity of the encoded protein, a va
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0c44ab12d0f2ed0c941e57cd4ae7f0cd
https://doi.org/10.4161/cc.10.4.14729
https://doi.org/10.4161/cc.10.4.14729
Publikováno v:
Cell Stress and Chaperones. 15:753-759
The Hsp90 molecular chaperone has been implicated as a contributor to evolution in several organisms by revealing cryptic variation that can yield dramatic phenotypes when the chaperone is diverted from its normal functions by environmental stress. I
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f1d2387d224e7334afec093863a4199
https://doi.org/10.1007/s12192-010-0191-0
https://doi.org/10.1007/s12192-010-0191-0
Publikováno v:
Proceedings of the National Academy of Sciences. 107:692-697
Transcription stimulates the genetic instability of trinucleotide repeat sequences. However, the mechanisms leading to transcription-dependent repeat length variation are unclear. We demonstrate, using biochemical and genetic approaches, that the for
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::495d794b875530222d31b29ac86520fa
https://doi.org/10.1073/pnas.0909740107
https://doi.org/10.1073/pnas.0909740107