Výsledky vyhledávání

Safety and efficacy results of switch from imiglucerase to velaglucerase alfa treatment in patients with type 1 G aucher disease

Autor: Eric Crombez, Atul Mehta, Thomas N. Hangartner, Yune Kunes, Laurie D. Smith, Ari Zimran, Nan Wang, Joel Charrow, Derralynn Hughes, Suma P. Shankar, Deborah Elstein, P Giraldo

Publikováno v: American Journal of Hematology. 90:592-597

Gaucher disease (GD) is a lysosomal storage disorder; symptomatic patients with type 1 GD need long-term disease-specific therapy of which the standard of care has been enzyme replacement therapy (ERT). Thirty-eight of 40 patients (aged 9–71 years)

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b04cee316c2e812b420bc802fea5b627
https://doi.org/10.1002/ajh.24007

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Expression of antibodies using single open reading frame (sORF) vector design

Autor: Santora Ling C, Yune Kunes, Sahana Bose, Emma Fung, Limary Medina, Rachel A. Davis-Taber, Chris Chumsae, Alexander V. Ivanov, Wendy Gion, Gerald R. Carson, Dean A. Regier, Barbara A. Perilli-Palmer, Joseph G. Matuck

Publikováno v: mAbs

Efficient production of large quantities of therapeutic antibodies is becoming a major goal of the pharmaceutical industry. We developed a proprietary expression system using a polyprotein precursor-based approach to antibody expression in mammalian

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000de2b88ef503c1a5874190bd20448c
https://doi.org/10.4161/mabs.25161

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Expression of antibodies using single-open reading frame vector design and polyprotein processing from mammalian cells

Autor: Wendy Gion, Gerald R. Carson, Jochen G. Salfeld, Yune Kunes, Paul Sakorafas, Emma Fung, Rong-Rong Zhu

Publikováno v: Biotechnology Progress. 25:735-744

We describe a novel polyprotein precursor-based approach to express antibodies from mammalian cells. Rather than expressing heavy and light chain proteins from separate expression units, the antibody heavy and light chains are contained in one single

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f4b23ed254f820141b3534ee794ece07
https://doi.org/10.1002/btpr.182

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Abstract 4606: Preclinical characterization of a novel fully human IgG1 anti-PD-L1 mAb CK-301

Autor: George Avgerinos, Wayne A. Marasco, Yune Kunes, Leonid Gorelik

Publikováno v: Cancer Research. 77:4606-4606

Antibodies targeting Programmed Death-1 (PD-1), or its ligand, PD-L1, have demonstrated remarkable efficacy in subsets of cancer patients, with inhibition of the interaction between PD-1 on T-cells and PD-L1 on tumor cells leading to the recovery of

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::60eaf7f33508907c3410e37c1275e4f2
https://doi.org/10.1158/1538-7445.am2017-4606

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Limited clinical impact of anti-idursulfase antibodies developed during long-term idursulfase enzyme replacement therapy (ERT) in mucopolysaccharidosis II (MPS II, Hunter syndrome) patients aged 5-35 years

Autor: Christian J. Hendriksz, Ann J. Barbier, Yune Kunes, Ashok Vellodi, Bonnie Bielefeld, Roberto Giugliani, Suresh Vijayaraghavan, Paul Harmatz, Kenneth Sciarappa, Arian Pano, Nancy J. Mendelsohn

Publikováno v: Molecular Genetics and Metabolism. 111:S53

38% by 240 weeks (n= 5). Forced expiratory volume (FEV1) increased approximately 11% at 96 weeks (n = 33) and was maintained at 240 weeks (n= 5) (3). After 7 years, FVC improved by 47% (n= 5) and FEV1 by 34% (n= 6), showing continued upward trajector

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1d72b22590495820ef0ce15009fd6c75
https://doi.org/10.1016/j.ymgme.2013.12.113

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