Zobrazeno 1 - 10
of 99
pro vyhledávání: '"Yuncai Chen"'
Autor:
Matthew T. Birnie, Annabel K. Short, Gregory B. de Carvalho, Lara Taniguchi, Benjamin G. Gunn, Aidan L. Pham, Christy A. Itoga, Xiangmin Xu, Lulu Y. Chen, Stephen V. Mahler, Yuncai Chen, Tallie Z. Baram
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Reward circuit dysfunction is a mechanism for key emotional disorders that commonly arise after early life stresses (ELA). Here, the authors discover a projection from amygdala to nucleus accumbens that underlies ELA-induced reward deficits in mice.
Externí odkaz:
https://doaj.org/article/66e790ddc14546f682653fadabc8c1a6
Autor:
Annabel K. Short, Christina W. Thai, Yuncai Chen, Noriko Kamei, Aidan L. Pham, Matthew T. Birnie, Jessica L. Bolton, Ali Mortazavi, Tallie Z. Baram
Publikováno v:
Biological Psychiatry Global Open Science, Vol 3, Iss 1, Pp 99-109 (2023)
Background: Mental health and vulnerabilities to neuropsychiatric disorders involve the interplay of genes and environment, particularly during sensitive developmental periods. Early-life adversity (ELA) and stress promote vulnerabilities to stress-r
Externí odkaz:
https://doaj.org/article/36084c5dad3d4921b7406a533444ff1b
Autor:
Ying Lyu, Zhongqiang Su, Guosheng Ye, Xiulan He, Yue Liu, Qiao Yin, Fanbing Xie, Liping Xu, Yuncai Chen, Dahong Long
Publikováno v:
Experimental Gerontology, Vol 179, Iss , Pp 112243- (2023)
The differentiation of human induced pluripotent stem cells (hiPSCs) into functional dopaminergic neural precursors is the basis of cell therapy for Parkinson's disease (PD). However, the use of small molecule inhibitors/activators in the differentia
Externí odkaz:
https://doaj.org/article/3234bff69bcc43ddbb1b4f75773f0f90
Publikováno v:
Applied Sciences, Vol 13, Iss 20, p 11197 (2023)
Investigating the mechanism and measures of controlling rockburst in deeply buried underground caverns is a prerequisite for ensuring the safety of personnel, reducing the damage to construction equipment caused by the rockburst, and making the proje
Externí odkaz:
https://doaj.org/article/7bebedd57e1340dd9082630fdb0c0f0b
Autor:
Jessica L. Bolton, Anton Schulmann, Megan M. Garcia-Curran, Limor Regev, Yuncai Chen, Noriko Kamei, Manlin Shao, Akanksha Singh-Taylor, Shan Jiang, Yoav Noam, Jenny Molet, Ali Mortazavi, Tallie Z. Baram
Publikováno v:
Cell Reports, Vol 33, Iss 11, Pp 108511- (2020)
Summary: Early-life adversity (ELA) is associated with lifelong memory deficits, yet the responsible mechanisms remain unclear. We impose ELA by rearing rat pups in simulated poverty, assess hippocampal memory, and probe changes in gene expression, t
Externí odkaz:
https://doaj.org/article/4bf6ad0ca44047a889a6263685153df9
Autor:
Rachael Hokenson, Mikko Oijala, Annabel Short, Jessica Bolton, Yuncai Chen, Jenny Molet, Pamela Maras, Tallie Baram, Gyorgy Lur
Publikováno v:
Bio-Protocol, Vol 10, Iss 15 (2020)
Stress is crucial to the survival of an organism, but excessive stress can lead to psychological disorders including depression, anxiety, substance abuse, and suicidality. The prevailing notion is that chronic stress promotes adverse outcomes on brai
Externí odkaz:
https://doaj.org/article/086c126c34ce47d9821915f7daac9a9a
Publikováno v:
Neurobiology of Disease, Vol 132, Iss , Pp - (2019)
The effects of prolonged physical training on memory performance and underlying presynaptic mechanisms were investigated in old C57BL/6 mice. Training via voluntary running wheels was initiated at 16 months of age and continued for 5 months (1 h per
Externí odkaz:
https://doaj.org/article/8973ed0530cf4dd68b9a491100069239
Autor:
Gary P. Brennan, Deblina Dey, Yuncai Chen, Katelin P. Patterson, Eric J. Magnetta, Alicia M. Hall, Celine M. Dube, Yu-Tang Mei, Tallie Z. Baram
Publikováno v:
Cell Reports, Vol 14, Iss 10, Pp 2402-2412 (2016)
Insult-provoked transformation of neuronal networks into epileptic ones involves multiple mechanisms. Intervention studies have identified both dysregulated inflammatory pathways and NRSF-mediated repression of crucial neuronal genes as contributors
Externí odkaz:
https://doaj.org/article/88446abf8b09460bbe0e2bd94ee45b66
Autor:
Xiao-Dong Wang, Yuncai Chen, Miriam Wolf, Klaus V. Wagner, Claudia Liebl, Sebastian H. Scharf, Daniela Harbich, Bianca Mayer, Wolfgang Wurst, Florian Holsboer, Jan M. Deussing, Tallie Z. Baram, Marianne B. Müller, Mathias V. Schmidt
Publikováno v:
Neurobiology of Disease, Vol 42, Iss 3, Pp 300-310 (2011)
Chronic stress evokes profound structural and molecular changes in the hippocampus, which may underlie spatial memory deficits. Corticotropin-releasing hormone (CRH) and CRH receptor 1 (CRHR1) mediate some of the rapid effects of stress on dendritic
Externí odkaz:
https://doaj.org/article/fbdb9b61308c47a4807c7303fdc0d0aa
Autor:
Hall, Alicia M., Noriko Kamei, Manlin Shao, Hyun-Seung Mun, Chen, Kevin, Yuncai Chen, Baram, Tallie Z.
Publikováno v:
eNeuro; May2024, Vol. 11 Issue 5, p1-9, 9p