Zobrazeno 1 - 10
of 62
pro vyhledávání: '"Yunbo Qiao"'
Autor:
Yuting Zhao, Min Li, Jie Liu, Xiaowen Xue, Jingli Zhong, Jianxiang Lin, Bo Ye, Jun Chen, Yunbo Qiao
Publikováno v:
Computational and Structural Biotechnology Journal, Vol 21, Iss , Pp 856-868 (2023)
Base editing tools enable precise genome modifications, disease modeling, and promising gene therapy. However, many human genetic diseases are elicited by multi-nucleotide variants (MNVs) with heterogeneous substitutions at the same genomic locus. Ba
Externí odkaz:
https://doaj.org/article/3751f610acf24dcf892aa48a3987aeac
Autor:
Xiaoguo Zheng, Zhenhua Li, Guishuan Wang, Hanshu Wang, Yuchuan Zhou, Xinzhi Zhao, C. Yan Cheng, Yunbo Qiao, Fei Sun
Publikováno v:
Cell Discovery, Vol 7, Iss 1, Pp 1-22 (2021)
Abstract Paternal life experiences impact offspring health via germline, and epigenetic inheritance provides a potential mechanism. However, global reprogramming during offspring embryogenesis and gametogenesis represents the largest hurdle to concep
Externí odkaz:
https://doaj.org/article/b56829ef06ea44df98e88ccc92fb2155
Autor:
Jianxiang Lin, Xingchen Liu, Zongyang Lu, Shisheng Huang, Susu Wu, Wenxia Yu, Yao Liu, Xiaoguo Zheng, Xingxu Huang, Qiang Sun, Yunbo Qiao, Zhen Liu
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 25, Iss , Pp 494-501 (2021)
Prime editing enables efficient introduction of targeted transversions, insertions, and deletions in mammalian cells and several organisms. However, genetic disease models with base deletions by prime editing have not yet been reported in mice. Here,
Externí odkaz:
https://doaj.org/article/6660187d2dc3426d8bc611ea355af90e
Autor:
Jian Yuan, Qi Jiang, Tongyang Gong, Dandan Fan, Ji Zhang, Fukun Chen, Xiaolin Zhu, Xinyu Wang, Yunbo Qiao, Hongyan Chen, Zhihua Liu, Jianzhong Su
Publikováno v:
npj Genomic Medicine, Vol 6, Iss 1, Pp 1-11 (2021)
Abstract Trimethylation of histone H3 lysine 27 trimethylation (H3K27me3) may be recruited by repressive Polycomb complexes to mediate gene silencing, which is critical for maintaining embryonic stem cell pluripotency and differentiation. However, th
Externí odkaz:
https://doaj.org/article/7e95ae9d883948b0bed0b14b04be523f
Autor:
Jianan Li, Jianxiang Lin, Shisheng Huang, Min Li, Wenxia Yu, Yuting Zhao, Junfan Guo, Pumin Zhang, Xingxu Huang, Yunbo Qiao
Publikováno v:
Advanced Science, Vol 9, Iss 30, Pp n/a-n/a (2022)
Abstract Selective inhibition of targeted protein kinases is an effective therapeutic approach for treatment of human malignancies, which interferes phosphorylation of cellular substrates. However, a drug‐imposed selection creates pressures for tum
Externí odkaz:
https://doaj.org/article/3138ac8b45f34d1c87bd25c3ed52f91a
Autor:
Bo Ye, Dandan Fan, Weiwei Xiong, Min Li, Jian Yuan, Qi Jiang, Yuting Zhao, Jianxiang Lin, Jie Liu, Yilv Lv, Xiongjun Wang, Zhigang Li, Jianzhong Su, Yunbo Qiao
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-16 (2021)
The role of regulatory cis-elements in carcinogenesis and metastasis in esophageal squamous cell carcinoma remains crucial. Here the authors investigate H3K27ac-marked active enhancer profiles and transcriptomes in different types of esophageal tissu
Externí odkaz:
https://doaj.org/article/1f28e58954f6472a90d785799d564ad2
Autor:
Jianan Li, Wenxia Yu, Shisheng Huang, Susu Wu, Liping Li, Jiankui Zhou, Yu Cao, Xingxu Huang, Yunbo Qiao
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-8 (2021)
Base editors can induce transcriptome-wide RNA off-target editing independent of gRNA. Here, the authors engineer ABEmax variants with minimized RNA off-target activities.
Externí odkaz:
https://doaj.org/article/4bd9786b378c4e9cb51a4b505bd69951
Autor:
Susu Wu, Liping Li, Min Li, Shiyu Sun, Yuting Zhao, Xiaowen Xue, Feiyu Chen, Jingli Zhong, Junfan Guo, Qianhui Qu, Xiongjun Wang, Zhen Liu, Yunbo Qiao
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 10 (2022)
CRISPR/Cas9-based base editing tools enable precise genomic installation and hold great promise for gene therapy, whereas the big size of Cas9 nucleases and its reliability on specific protospacer adjacent motif (PAM) sequences as well as target site
Externí odkaz:
https://doaj.org/article/2a27e316e59c41599d206087ffe1f7e7
Autor:
Yunbo Qiao, Chao Ren, Shisheng Huang, Jie Yuan, Xingchen Liu, Jiao Fan, Jianxiang Lin, Susu Wu, Qiuzhen Chen, Xiaochen Bo, Xiangyang Li, Xingxu Huang, Zhen Liu, Wenjie Shu
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-13 (2020)
Until now, the transcriptome of preimplantation mouse embryos has only been analysed by short-read sequencing. Here, the authors perform long-read sequencing to provide a more detailed transcriptome of the preimplantation mouse embryo, identifying va
Externí odkaz:
https://doaj.org/article/8037144ef5c94845a8eb375c83c2098a
Autor:
Xinyi Liu, Guanglei Li, Xueliang Zhou, Yunbo Qiao, Ruixuan Wang, Shaohui Tang, Jianqiao Liu, Lisheng Wang, Xingxu Huang
Publikováno v:
Molecular Therapy: Nucleic Acids, Vol 17, Iss , Pp 626-635 (2019)
The development of CRISPR/Cas9-mediated base editors (BEs) provided a versatile tool for precise genome editing. The recently developed xCas9-derived base editors (xBEs) that recognize the NG PAM substantially expand the targeting scope in the genome
Externí odkaz:
https://doaj.org/article/76b3cdd98a0b44eaa26def60bb4e0df8