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pro vyhledávání: '"Yuna Okada"'
Autor:
Toru Bando, Yukie Nojiri, Akira Komada, Eiichi Sakurai, Yukari Ueda, Tadatoshi Tanino, Yuna Okada
Publikováno v:
Drug Metabolism and Disposition. 45:1189-1196
Flavin-containing monooxygenases (FMOs) are major mammalian non-cytochrome P450 oxidative enzymes. T helper 2 cell–activated allergic diseases produce excess levels of nitric oxide (NO) that modify the functions of proteins. However, it remains unc
Autor:
Tadatoshi Tanino, Yukie Nojiri, Yukari Ueda, Yuna Okada, Eiichi Sakurai, Toru Bando, Kanako Hashimoto
Publikováno v:
European journal of drug metabolism and pharmacokinetics. 44(3)
Mast cell-mediated allergic diseases are a significant global health problem. Nitric oxide (NO) produced by acute type 1 allergies greatly suppresses hepatic cytochrome P450 (CYP) metabolism. A recent in vitro study demonstrated that repeated FceRI-m