Zobrazeno 1 - 10
of 49
pro vyhledávání: '"Yun-Yan Xiang"'
Publikováno v:
PLoS ONE, Vol 6, Iss 10, p e26225 (2011)
Pancreatic islet β-cells produce large amounts of γ-aminobutyric acid (GABA), which is co-released with insulin. GABA inhibits glucagon secretion by hyperpolarizing α-cells via type-A GABA receptors (GABA(A)Rs). We and others recently reported tha
Externí odkaz:
https://doaj.org/article/7b664b80fa2c40e5b87090ca336eccaa
Autor:
Hae-Ra Cho, Junichi Sugihara, Hiroki Shimizu, Yun-Yan Xiang, Xiaohui Bai, Yingchun Wang, Xiao-Hui Liao, Sylvia L. Asa, Samuel Refetoff, Mingyao Liu
Publikováno v:
Thyroid
BACKGROUND: Multinodular goiter (MNG) is the most common disorder of the thyroid gland. Aging and genetic mutations that impair thyroid hormone (TH) production have been implicated in the development of MNG. XB130 is an adaptor/scaffold protein predo
Autor:
Junichi Sugihara, Peter Arvan, Mingyao Liu, Samuel Refetoff, Yingchun Wang, Wei-Yang Lu, Yun-Yan Xiang, Xiao Hui Liao
Publikováno v:
Thyroid
Background: XB130 (actin filament-associated protein 1-like 2, AFAP1L2) is a thyroid-abundant adaptor/scaffold protein. Xb130(−/−) mice exhibit transient growth retardation postnatally due to congenital hypothyroidism with diminished thyroglobuli
Autor:
Peter Arvan, Yun-Yan Xiang, Samuel Refetoff, Xiao Hui Liao, Yingchun Wang, Xiao-Hui Bai, Hae-Ra Cho, Hiroki Shimizu, Mingyao Liu, Junichi Sugihara, Hiroaki Toba, Sylvia L. Asa, Wei-Yang Lu
Publikováno v:
Thyroid
Background: Congenital hypothyroidism is often caused by genetic mutations that impair thyroid hormone (TH) production, resulting in growth and development defects. XB130 (actin filament associated protein 1 like 2) is an adaptor/scaffold protein tha
Autor:
Lei Huang, Olivia Hough, Ravi N. Vellanki, Mamoru Takahashi, Zhiyuan Zhu, Yun-Yan Xiang, Manyin Chen, Hemant Gokhale, Hongchao Shan, Sahar Soltanieh, Lei Jing, Xinliang Gao, Bradly G. Wouters, Marcelo Cypel, Shaf Keshavjee, Mingyao Liu
Publikováno v:
The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation.
The clinical application of normothermic ex vivo lung perfusion (EVLP) has increased donor lung utilization for transplantation through functional assessment. To develop it as a platform for donor lung repair, reconditioning and regeneration, the per
Publikováno v:
The Cerebellum. 19:510-526
Nitric oxide (NO), specifically derived from neuronal nitric oxide synthase (nNOS), is a well-established regulator of synaptic transmission in Purkinje neurons (PNs), governing fundamental processes such as motor learning and coordination. Previous
Publikováno v:
Nitric Oxide. 94:125-134
Microglia population is primarily determined by a finely-regulated proliferation process during early development of the central nervous system (CNS). Nitric oxide (NO) is known to inhibit proliferation in numerous cell types. However, how NO signali
Publikováno v:
Glia. 67:2294-2311
Microglia phagocytosis is critical for central nervous system development, and dysregulation of phagocytosis may contribute to a variety of neurological disorders. During initial stages of phagocytosis, microglia display increased nitric oxide (NO) p
Autor:
Ayman Al Habeeb, Hae-Ra Cho, Yun-Yan Xiang, Alexander Post, Xiao-Hui Bai, Christina Lu, Mingyao Liu, Yingchun Wang
Publikováno v:
Carcinogenesis. 40:1363-1375
XB130 is an adaptor protein that functions as a mediator of multiple tyrosine kinases important for regulating cell proliferation, survival, migration and invasion. Formerly predicted as an oncogene, alterations of its expression are documented in va
Autor:
Yun-Yan Xiang, Haibo Zhang, Sean P. Cregan, Matthew J.E. Maksoud, Jacob W. Poirier, Gregory A. Dekaban, Sean E. Gill, Luan Januzi, Rudolf A.W. Veldhuizen, Wei-Yang Lu
Publikováno v:
Cellular Immunology. 332:7-23
In response to micro-environmental cues such as microbial infections or T-helper 1 and 2 (TH1 and TH2) cytokines, macrophages (Mϕs) develop into M1- or M2-like phenotypes. Phenotypic polarization/activation of Mϕs are also essentially regulated by