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C-Terminal modification of polytheonamide B uncouples its dual functions in MCF-7 cancer cells

Autor: Yun-Wei Xue, Kensuke Miura, Hiroaki Itoh, Masayuki Inoue

Publikováno v: Chemical Communications. 59:3914-3917

Polytheonamide B is a large natural product that forms an ion channel in the plasma and lysosomal membranes. Herein, we report the uncoupling of the dual functions of polytheonamide B by synthetically incorporating a tertiary amine at the C-terminus.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d0fcaf5930b2498a55128e7c63bba169
https://doi.org/10.1039/d2cc05915k

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Gramicidin A accumulates in mitochondria, reduces ATP levels, induces mitophagy, and inhibits cancer cell growth

Autor: Yun-Wei Xue, Hiroaki Itoh, Shingo Dan, Masayuki Inoue

Publikováno v: Chemical Science. 13:7482-7491

Here we revealed the spatiotemporal behavior of gramicidin A in cancer cells. Gramicidin A depolarizes both the plasma and mitochondrial membranes, inhibits ATP synthesis, and induces mitophagy, thereby causing potent inhibition of cell growth.

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::355caeffaafd223054694e9add610ade
https://doi.org/10.1039/d2sc02024f

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Biological Effects of a Simplified Synthetic Analogue of Ion-Channel-Forming Polytheonamide B on Plasma Membrane and Lysosomes

Autor: Masayuki Inoue, Yun-Wei Xue, Hiroaki Itoh, Atsushi Hayata

Publikováno v: Chemistry (Weinheim an der Bergstrasse, Germany). 25(66)

Polytheonamide B (1) is a linear 48-mer natural peptide with alternating d- and l-amino acid residues. Compound 1 forms conducting channels for monovalent ions and exhibits potent cytotoxicity against MCF-7 cells. Previously, we reported that nanomol

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a0461d1e4b736341413b8eb644f9c849
https://pubmed.ncbi.nlm.nih.gov/31549755

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Modification mechanism of coal-tar pitch-based carbon microspheres by an emulsion method with petroleum pitch

Autor: Yong-gen Lu, Yun-wei Xue, Ding Pan, Peng Wang, Hai-qin Rong, Changling Yang

Publikováno v: New Carbon Materials. 23:75-80

Coal-tar pitch-based carbon microspheres were prepared by adding petroleum pitch using emulsifying pitch-toluene colloidal solution in polyvinyl alcohol (PVA) glycerol solution. To clarify the influence of pitch solubility in toluene and its affinity

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::899caecb211d73626ce60212e3863b2e
https://doi.org/10.1016/s1872-5805(08)60013-x

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