Zobrazeno 1 - 10
of 132
pro vyhledávání: '"Yun-Chien Chang"'
Decrypting lysine deacetylase inhibitor action and protein modifications by dose-resolved proteomics
Autor:
Yun-Chien Chang, Christian Gnann, Raphael R. Steimbach, Florian P. Bayer, Severin Lechner, Amirhossein Sakhteman, Miriam Abele, Jana Zecha, Jakob Trendel, Matthew The, Emma Lundberg, Aubry K. Miller, Bernhard Kuster
Publikováno v:
Cell Reports, Vol 43, Iss 6, Pp 114272- (2024)
Summary: Lysine deacetylase inhibitors (KDACis) are approved drugs for cutaneous T cell lymphoma (CTCL), peripheral T cell lymphoma (PTCL), and multiple myeloma, but many aspects of their cellular mechanism of action (MoA) and substantial toxicity ar
Externí odkaz:
https://doaj.org/article/675013f87a3d4a3d988e68db6e78c7c5
Autor:
Yi-Hsuan Lin, Nai-Rong Kuo, Hsiao-Chin Shen, Yun-Chien Chang, Roger Lin, Tsai-Ling Liao, Hsiao-Yun Yeh, Ying-Ying Yang, Ming-Chih Hou, Han-Chieh Lin
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-12 (2023)
Abstract The development of acute kidney injury (AKI) and hepatorenal syndrome–acute kidney injury (HRS–AKI) in cirrhosis has been associated with intestinal barrier dysfunction and gut-kidney crosstalk. We use the related markers such as zonulin
Externí odkaz:
https://doaj.org/article/df8652d957f2474cb52ed6b31da9da0c
Autor:
Severin Lechner, Raphael R. Steimbach, Longlong Wang, Marshall L. Deline, Yun-Chien Chang, Tobias Fromme, Martin Klingenspor, Patrick Matthias, Aubry K. Miller, Guillaume Médard, Bernhard Kuster
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract Lipoic acid is an essential enzyme cofactor in central metabolic pathways. Due to its claimed antioxidant properties, racemic (R/S)-lipoic acid is used as a food supplement but is also investigated as a pharmaceutical in over 180 clinical tr
Externí odkaz:
https://doaj.org/article/ed182da2a1c645a1ab1612e13877687d
Autor:
Chia-Chang Huang, Hsiao-Chin Shen, Roger Lin, Ying-Ying Yang, Yun-Chien Chang, Tsai-Ling Liao, Shiang-Fen Huang, Han-Chieh Lin, Ming-Chih Hou
Publikováno v:
Journal of Pharmacological Sciences, Vol 152, Iss 1, Pp 50-60 (2023)
Cirrhosis-related hepatic and renal endothelial dysfunction is characterized by macrophage-endothelium adhesion-mediated inflammation, glycocalyx/barrier damage, and impaired vasodilation. Activation of adenosine A2A receptor (A2AR) protects cirrhoti
Externí odkaz:
https://doaj.org/article/a83ffc879d70466e95d6fadfa3173ebd
Autor:
Jana Zecha, Wassim Gabriel, Ria Spallek, Yun-Chien Chang, Julia Mergner, Mathias Wilhelm, Florian Bassermann, Bernhard Kuster
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-14 (2022)
Post-translational modifications (PTMs) can regulate cellular protein function but their global impact on protein turnover is largely unknown. Here, the authors develop proteomic workflows to profile PTM-resolved protein turnover and analyze the effe
Externí odkaz:
https://doaj.org/article/629f5a02a56949d3a37bcf1ab0caac97
Autor:
Reta Birhanu Kitata, Wai-Kok Choong, Chia-Feng Tsai, Pei-Yi Lin, Bo-Shiun Chen, Yun-Chien Chang, Alexey I. Nesvizhskii, Ting-Yi Sung, Yu-Ju Chen
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-14 (2021)
Phosphoproteomics can provide systematic insights into disease-associated cell signaling changes. Here, the authors present a sensitive workflow integrating library-based and direct data-independent acquisition approaches, and a hybrid spectral libra
Externí odkaz:
https://doaj.org/article/86260f2d4cfc4d5badf02ec996ec67af
Autor:
Yangyang Bian, Runsheng Zheng, Florian P. Bayer, Cassandra Wong, Yun-Chien Chang, Chen Meng, Daniel P. Zolg, Maria Reinecke, Jana Zecha, Svenja Wiechmann, Stephanie Heinzlmeir, Johannes Scherr, Bernhard Hemmer, Mike Baynham, Anne-Claude Gingras, Oleksandr Boychenko, Bernhard Kuster
Publikováno v:
Nature Communications, Vol 11, Iss 1, Pp 1-12 (2020)
Mass spectrometry-based proteomics typically relies on highly sensitive nano-flow liquid chromatography (LC) but this can reduce robustness and reproducibility. Here, the authors show that micro-flow LC enables robust and reproducible high-throughput
Externí odkaz:
https://doaj.org/article/51978dfc79c64bbfbbf6af243fbb23c2
Past research and literature suggest that legal institutions drive economic development. Yet China has grown for decades without the fundamental legal infrastructure that was once considered necessary. This is called the'China puzzle'or the'China myt
Autor:
Yun-chien Chang
Possession is a key concept in both the common and civil law, but it has hitherto received little scrutiny. Law and Economics of Possession uses insights from economics, psychology and history to analyse possession in law, compare and contrast posses
Autor:
Yun-Chien Chang, 張允謙
99
This paper intends to improve the research by Hou (2010) research, which combines an MOPSO algorithm with a simulation model to solve a supply chain inventory management problem. The algorithm implements a technique called Kriging to forecast
This paper intends to improve the research by Hou (2010) research, which combines an MOPSO algorithm with a simulation model to solve a supply chain inventory management problem. The algorithm implements a technique called Kriging to forecast
Externí odkaz:
http://ndltd.ncl.edu.tw/handle/08455701546876184847