Zobrazeno 1 - 9
of 9
pro vyhledávání: '"Yun-Biao Lu"'
Autor:
Nan-Yu Wang, Shu-ting Liang, Xiao-Feng Chen, De-Long Hao, Hou-Zao Chen, Zhu-Qin Zhang, Xiang Zhao, Xiaoqiang Tang, Yun-Biao Lu, Ming-Hui Zou, Xiao-Man Wang, De-Pei Liu, Wei Zheng
Publikováno v:
Circulation. 136:2051-2067
Background: Pathological cardiac hypertrophy induced by stresses such as aging and neurohumoral activation is an independent risk factor for heart failure and is considered a target for the treatment of heart failure. However, the mechanisms underlyi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b8d0355b6b5e605878631a73c779c18f
https://doi.org/10.1161/circulationaha.117.028728
https://doi.org/10.1161/circulationaha.117.028728
Autor:
Wenyan Fu, Wei Zheng, De-Pei Liu, Wen-li Mu, Hongliang Li, Yun-Biao Lu, Li Li, Qing-Jun Zhang, Zhi-Gang She, Xiaoqiang Tang, Hou-Zao Chen, Yu-Sheng Wei
Publikováno v:
Science China Life Sciences. 57:915-924
SIRT1, a mammalian ortholog of yeast silent information regulator 2 (Sir2), is an NAD(+)-dependent protein deacetylase that plays a critical role in the regulation of vascular function. The current study aims to investigate the functional significanc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c01a101dece1d5c439e6e19b6eaba08c
https://doi.org/10.1007/s11427-014-4687-1
https://doi.org/10.1007/s11427-014-4687-1
SIRT1 deacetylates the cardiac transcription factor Nkx2.5 and inhibits its transcriptional activity
Autor:
Zhu Qin Zhang, Xiaoqiang Tang, Lei Han, Shu Ting Liang, De-Pei Liu, Xiao-Feng Chen, Gong-Hong Wei, Hou-Zao Chen, Wei Zheng, Yun Biao Lu, Han Ma
Publikováno v:
Scientific Reports
The homeodomain transcription factor Nkx2.5/Csx is critically essential for heart specification, morphogenesis, and homeostasis. Acetylation/deacetylation is important for the localization, stability and activation of transcription factors. It remain
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::225e25fc923a965673e8465b22a6dde4
Autor:
Zhi-Chen Guo, De-Pei Liu, Xiang Zhao, Feng Chen, Yan-Zhen Wan, De-Long Hao, Hou-Zao Chen, Yun-Biao Lu, Shuang Zhou, Ran Zhang, Zhu-Qin Zhang, Chih-Chuan Liang
Publikováno v:
Science China Life Sciences. 55:467-473
The rapidly increasing prevalence of diabetes mellitus worldwide is one of the most serious and challenging health problems in the 21st century. Mammalian sirtuin 1 (SIRT1) has been shown to decrease high-glucose-induced endothelial cell senescence i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::e5d29f29c76f571dec5b1d8344060365
https://doi.org/10.1007/s11427-012-4329-4
https://doi.org/10.1007/s11427-012-4329-4
Autor:
Zhen Xu, Hou-Zao Chen, Zhi-Gang She, Yun-Biao Lu, Jing Xu, Wei Zheng, Shu-ting Liang, Zhu-Qin Zhang, De-Pei Liu, Ruifeng Yang, Qing-Jun Zhang, Li Li, De-Long Hao, Yu-Sheng Wei, Jie Lu, Bei-Bei Mao
Publikováno v:
Basic Research in Cardiology. 108
Nkx2.5 plays protective roles in cardiac homeostasis and survival in the postnatal hearts. However, the underlying molecular mechanisms that mediate the protective functions of Nkx2.5 remain unknown. Here, we showed that Nkx2.5 was downregulated in r
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9da359501ca76890ecd89f38818884b4
https://doi.org/10.1007/s00395-013-0364-y
https://doi.org/10.1007/s00395-013-0364-y
Autor:
De-Pei Liu, Yan-Zhen Wan, Hua Cai, Shuai Huang, Shuang Zhou, Zhu-Qin Zhang, Ruifeng Yang, Chih-Chuan Liang, Ran Zhang, Yu-Sheng Wei, Yun-Biao Lu, Hou-Zao Chen, Jinjing Liu, Qing-Jun Zhang
Publikováno v:
Circulation research. 109(6)
Rationale: Inactivation of the p66Shc adaptor protein confers resistance to oxidative stress and protects mice from aging-associated vascular diseases. However, there is limited information about the negative regulating mechanisms of p66Shc expressio
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7af2329c818d5b1843c62579177a6de9
https://pubmed.ncbi.nlm.nih.gov/21778425
https://pubmed.ncbi.nlm.nih.gov/21778425
Autor:
Xiaoqiang Tang, Xiao-Feng Chen, Nan-Yu Wang, Xiao-Man Wang, Shu-Ting Liang, Wei Zheng, Yun-Biao Lu, Xiang Zhao, De-Long Hao, Zhu-Qin Zhang, Ming-Hui Zou, De-Pei Liu, Hou-Zao Chen, Tang, Xiaoqiang, Chen, Xiao-Feng, Wang, Nan-Yu, Wang, Xiao-Man, Liang, Shu-Ting, Zheng, Wei, Lu, Yun-Biao
Publikováno v:
Circulation; 11/21/2017, Vol. 136 Issue 21, p2051-2067, 17p
Publikováno v:
The Journal of biological chemistry. 280(24)
Insulin-like growth factor binding protein-3 (IGFBP-3) is a well documented growth inhibitor and pro-apoptotic factor. IGFBP-3 mRNA and its protein are overexpressed by senescent human diploid fibroblasts. However, the mechanism responsible for the u
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4321f4bec65012fa2aaa7d609cda2ac9
https://pubmed.ncbi.nlm.nih.gov/15817480
https://pubmed.ncbi.nlm.nih.gov/15817480
Publikováno v:
Journal of Biological Chemistry. 6/17/2005, Vol. 280 Issue 24, p22606-22615. 10p.