Výsledky vyhledávání - "Yun Xiang Liang"

Akademický článek

Specificity and Function of Archaeal DNA Replication Initiator Proteins

Autor: Rachel Y. Samson, Yanqun Xu, Catarina Gadelha, Todd A. Stone, Jamal N. Faqiri, Dongfang Li, Nan Qin, Fei Pu, Yun Xiang Liang, Qunxin She, Stephen D. Bell

Publikováno v: Cell Reports, Vol 3, Iss 2, Pp 485-496 (2013)

Chromosomes with multiple DNA replication origins are a hallmark of Eukaryotes and some Archaea. All eukaryal nuclear replication origins are defined by the origin recognition complex (ORC) that recruits the replicative helicase MCM(2-7) via Cdc6 and

Externí odkaz: https://doaj.org/article/1d4637191aec45bfa754b5f247072d53

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Inactivation of Target RNA Cleavage of a III-B CRISPR-Cas System Induces Robust Autoimmunity in Saccharolobus islandicus

Autor: Yan Zhang, Jinzhong Lin, Xuhui Tian, Yuan Wang, Ruiliang Zhao, Chenwei Wu, Xiaoning Wang, Pengpeng Zhao, Xiaonan Bi, Zhenxiao Yu, Wenyuan Han, Nan Peng, Yun Xiang Liang, Qunxin She

Publikováno v: International Journal of Molecular Sciences; Volume 23; Issue 15; Pages: 8515
Zhang, Y, Lin, J, Tian, X, Wang, Y, Zhao, R, Wu, C, Wang, X, Zhao, P, Bi, X, Yu, Z, Han, W, Peng, N, Liang, Y X & She, Q 2022, ' Inactivation of Target RNA Cleavage of a III-B CRISPR-Cas System Induces Robust Autoimmunity in Saccharolobus islandicus ', International Journal of Molecular Sciences, vol. 23, no. 15, 8515 . https://doi.org/10.3390/ijms23158515

Type III CRISPR-Cas systems show the target (tg)RNA-activated indiscriminate DNA cleavage and synthesis of oligoadenylates (cOA) and a secondary signal that activates downstream nuclease effectors to exert indiscriminate RNA/DNA cleavage, and both ac

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::20713f764e3c2067db1b01d44fbafcb7

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Cmr1 enables efficient RNA and DNA interference of a III-B CRISPR–Cas system by binding to target RNA and crRNA

Autor: Wenyuan Han, Qunxin She, Saifu Pan, Yun Xiang Liang, Yingjun Li, Nan Peng, Jinzhong Lin, Yan Zhang

Publikováno v: Nucleic Acids Research
Li, Y, Zhang, Y, Lin, J, Pan, S, Han, W, Peng, N, Liang, Y X & She, Q 2017, ' Cmr1 enables efficient RNA and DNA interference of a III-B CRISPR–Cas system by binding to target RNA and crRNA ', Nucleic Acids Research, vol. 45, no. 19, gkx791, pp. 11305-11314 . https://doi.org/10.1093/nar/gkx791

CRISPR–Cas (clustered regularly interspaced short palindromic repeats-CRISPR-associated) systems provide adaptive immunity against invasive nucleic acids guided by CRISPR RNAs (crRNAs) in archaea and bacteria. Type III CRISPR–Cas effector complex

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::794cfabc33ec1a56581a315029cb1e7c
http://europepmc.org/articles/PMC5737701

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A Membrane-Associated Nuclease Degrades Cyclic Oligo-Adenylate and Deactivates Type III CRISPR Ribonuclease

Autor: Ruiliang Zhao, Zhifeng Zeng, Jiayi Wang, Fan Zheng, Ke Yang, Wenqian Feng, Wenyuan Han, Qunxin She, Yun Xiang Liang, Xuexia Jin, Yang Yang

Publikováno v: SSRN Electronic Journal.

Type III CRISPR-Cas systems initiate an intracellular signaling pathway to confer immunity. The signalling pathway includes synthesis of cyclic oligo-adenylate (cOA) and activation of the RNase activity of type III accessory ribonuclease Csm6/Csx1 by

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::1ec12f8a99851fb215495dff52c1c9d5
https://doi.org/10.2139/ssrn.3551618

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A seed motif for target RNA capture enables efficient immune defence by a type III-B CRISPR-Cas system

Autor: Saifu Pan, Nan Peng, Qi Li, Ling Deng, Xuexia Jin, Suping Jiang, Qunxin She, Yingjun Li, Yun Xiang Liang

Publikováno v: RNA Biol

CRISPR-Cas systems provide an adaptive defence against foreign nucleic acids guided by small RNAs (crRNAs) in archaea and bacteria. The Type III CRISPR systems are reported to carry RNase, RNA-activated DNase and cyclic oligoadenylate (cOA) synthetas

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5b016fcc71f624861e32fac38142a06f
https://europepmc.org/articles/PMC6693533/

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A Membrane-Associated DHH-DHHA1 Nuclease Degrades Type III CRISPR Second Messenger

Autor: Qunxin She, Zhifeng Zeng, Xuexia Jin, Wenyuan Han, Ruiliang Zhao, Jiayi Wang, Yun Xiang Liang, Ke Yang, Fan Zheng, Yang Yang, Wenqian Feng

Publikováno v: Zhao, R, Yang, Y, Zheng, F, Zeng, Z, Feng, W, Jin, X, Wang, J, Yang, K, Liang, Y X, She, Q & Han, W 2020, ' A Membrane-Associated DHH-DHHA1 Nuclease Degrades Type III CRISPR Second Messenger ', Cell Reports, vol. 32, no. 11, 108133 . https://doi.org/10.1016/j.celrep.2020.108133

Summary Type III CRISPR-Cas systems initiate an intracellular signaling pathway to confer immunity. The signaling pathway includes synthesis of cyclic oligo-adenylate (cOA) and activation of the RNase activity of type III accessory ribonuclease Csm6/

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f2b214a79e0a4e4c776b5459cc2d8cfb
https://doi.org/10.1016/j.celrep.2020.108133

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An archaeal CRISPR type III-B system exhibiting distinctive RNA targeting features and mediating dual RNA and DNA interference

Autor: Qunxin She, Xu Feng, Mingxia Feng, Yun Xiang Liang, Wenfang Peng

Publikováno v: Nucleic Acids Research
Peng, W, Feng, M, Feng, X, Liang, Y X & She, Q 2015, ' An archaeal CRISPR type III-B system exhibiting distinctive RNA targeting features and mediating dual RNA and DNA interference ', Nucleic Acids Research, vol. 43, no. 1, pp. 406-417 . https://doi.org/10.1093/nar/gku1302

CRISPR-Cas systems provide a small RNA-based mechanism to defend against invasive genetic elements in archaea and bacteria. To investigate the in vivo mechanism of RNA interference by two type III-B systems (Cmr-α and Cmr-β) in Sulfolobus islandicu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3bac1ee775ef5b988bfc29a75a7cfdf4
http://europepmc.org/articles/PMC4288192

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Novel characteristics of chitin deacetylase from Colletotrichum lindemuthianum: Production of fully acetylated chitooligomers, and hydrolysis of deacetylated chitooligomers

Autor: Li-Xin Kang, Li-Xin Ma, Yun-Xiang Liang

Publikováno v: Process Biochemistry. 49:1936-1940

Although significant biochemical data are available on fungal chitin deacetylase from Colletotrichum lindemuthianum (ClCDA), novel characteristics do exist. Here the ClCDA, synthetized according to the codon usage bias and expressed in Pichia pastori

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::4c05666602d81745818c2c452d75d96d
https://doi.org/10.1016/j.procbio.2014.07.011

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Effects of a probiotic (Bacillus subtilisFY99-01) on the bacterial community structure and composition of shrimp (Litopenaeus vannamei, Boone) culture water assessed by denaturing gradient gel electrophoresis and high-throughput sequencing

Autor: Ding Xin Wu, Shu Miao Zhao, Chun Ping Xu, Yun Xiang Liang, Jun Wang, Nan Peng

Publikováno v: Aquaculture Research. 47:857-869

In China, many commercial probiotics are added as water additives into shrimp culture ponds with no sediment. In these ponds, probiotics should have great effects on the bacterial community of culture water at different culture stages. However, the s

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::99b79414550e2874328478227885dc75
https://doi.org/10.1111/are.12545

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A type III-B CRISPR-Cas effector complex mediating massive target DNA destruction

Autor: Wenyuan Han, Yingjun Li, Søren Hallstrøm, Nan Peng, Malcolm F. White, Ling Deng, Wenfang Peng, Qunxin She, Jing Zhang, Yun Xiang Liang, Mingxia Feng

Publikováno v: Han, W, Li, Y, Deng, L, Feng, M, Peng, W, Hallstrøm, S, Zhang, J, Peng, N, Liang, Y X, White, M F & She, Q 2017, ' A type III-B CRISPR-Cas effector complex mediating massive target DNA destruction ', Nucleic Acids Research, vol. 45, no. 4, gkw1274, pp. 1983–1993 . https://doi.org/10.1093/nar/gkw1274
Nucleic Acids Research

Funding: Biotechnology and Biological Sciences Research Council [BB/M000400/1 to MFW]. The CRISPR (clustered regularly interspaced short palindromic repeats) system protects archaea and bacteria by eliminating nucleic acid invaders in a crRNA-guided

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3675532a9b2cc5a86b9da8ee1724f28
https://curis.ku.dk/portal/da/publications/a-type-iiib-crisprcas-effector-complex-mediating-massive-target-dna-destruction(8d20d348-1c6f-4ce8-a6ac-7f8439f13704).html

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