Zobrazeno 1 - 10
of 153
pro vyhledávání: '"Yun ST"'
Autor:
Shu Su, Chao Quan, Qiaoli Chen, Ruizhen Wang, Qian Du, Sangsang Zhu, Min Li, Xinyu Yang, Ping Rong, Jiang Chen, Yingyu Bai, Wen Zheng, Weikuan Feng, Minjun Liu, Bingxian Xie, Kunfu Ouyang, Yun Stone Shi, Feng Lan, Xiuqin Zhang, Ruiping Xiao, Xiongwen Chen, Hong-Yu Wang, Shuai Chen
Publikováno v:
Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)
Abstract The obese heart undergoes metabolic remodeling and exhibits impaired calcium (Ca2+) homeostasis, which are two critical assaults leading to cardiac dysfunction. The molecular mechanisms underlying these alterations in obese heart are not wel
Externí odkaz:
https://doaj.org/article/27e902a593844c18bd0817ec2daf1200
Autor:
Marianela G. Dalghi, Ella DuRie, Wily G. Ruiz, Dennis R. Clayton, Nicolas Montalbetti, Stephanie B. Mutchler, Lisa M. Satlin, Thomas R. Kleyman, Marcelo D. Carattino, Yun Stone Shi, Gerard Apodaca
Publikováno v:
Physiological Reports, Vol 12, Iss 9, Pp n/a-n/a (2024)
Abstract The epithelial cells that line the kidneys and lower urinary tract are exposed to mechanical forces including shear stress and wall tension; however, the mechanosensors that detect and respond to these stimuli remain obscure. Candidates incl
Externí odkaz:
https://doaj.org/article/5aa6f4ad49de43d68e2bfdfa1f282fab
Autor:
Guolin Yang, Min Jia, Guizhou Li, Yan-Yu Zang, Yang-Yang Chen, Yue-Ying Wang, Shi-Yu Zhan, Shi-Xiao Peng, Guoqiang Wan, Wei Li, Jian-Jun Yang, Yun Stone Shi
Publikováno v:
Cell Discovery, Vol 10, Iss 1, Pp 1-15 (2024)
Abstract Thirst plays a vital role in the regulation of body fluid homeostasis and if deregulated can be life-threatening. Interoceptive neurons in the subfornical organ (SFO) are intrinsically osmosensitive and their activation by hyperosmolarity is
Externí odkaz:
https://doaj.org/article/f0ba90d0c37045fc9062e9199aebbddc
Autor:
Yuqi Qin, Daqi Yu, Dan Wu, Jiangqing Dong, William Thomas Li, Chang Ye, Kai Chit Cheung, Yingyi Zhang, Yun Xu, YongQiang Wang, Yun Stone Shi, Shangyu Dang
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-10 (2023)
Abstract The TMEM63 family proteins (A, B, and C), calcium-permeable channels in animals that are preferentially activated by hypo-osmolality, have been implicated in various physiological functions. Deficiency of these channels would cause many dise
Externí odkaz:
https://doaj.org/article/b6e8c5eec55a43a0b8a558e28ec02baa
Publikováno v:
Cells, Vol 13, Iss 21, p 1784 (2024)
The intestines are in a constant state of motion and self-renewal. The mechanical breakdown of food facilitates intestinal movement and aids digestion. It is believed that mechanical stimulation, triggered by changes in osmotic pressure within the in
Externí odkaz:
https://doaj.org/article/2761eb58828a4355aa10a4064603bb9c
Autor:
Shi-Xiao Peng, Yue-Ying Wang, Min Zhang, Yan-Yu Zang, Dan Wu, Jingwen Pei, Yansong Li, Jiapei Dai, Xiaoyun Guo, Xingguang Luo, Ning Zhang, Jian-Jun Yang, Chen Zhang, Xiang Gao, Na Liu, Yun Stone Shi
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-15 (2021)
Abstract In the brain, AMPA receptors mediate fast excitatory neurotransmission, the dysfunction of which leads to neuropsychiatric disorders. Synaptic function of AMPA receptors is tightly controlled by a protein group called transmembrane AMPAR reg
Externí odkaz:
https://doaj.org/article/7a275b7227e84e479d654815aa540827
Autor:
Nan Li, Shuzhan Gao, Shuang Wang, Sijie He, Jiayin Wang, Luqingqing He, Dongya Jiang, Yun Stone Shi, Jianguo Zhang, Yuan Gu, Tian Chen, Mingjun Kong, Xijia Xu, Qingshun Zhao
Publikováno v:
Frontiers in Cell and Developmental Biology, Vol 9 (2021)
Attractin (ATRN) is a widely expressed glycoprotein that is involved in energy homeostasis, neurodevelopment, and immune response. It is encoded by a gene spanning 180 kb on chromosome 20p13, a region previously implicated in schizophrenia by linkage
Externí odkaz:
https://doaj.org/article/8cfea9d2d54f400a948f755734ef30ef
Autor:
Jia-Hui Sun, Jiang Chen, Fernando Eduardo Ayala Valenzuela, Carolyn Brown, Diane Masser-Frye, Marilyn Jones, Leslie Patron Romero, Berardo Rinaldi, Wenhui Laura Li, Qing-Qing Li, Dan Wu, Benedicte Gerard, Erin Thorpe, Allan Bayat, Yun Stone Shi
Publikováno v:
PLoS Genetics, Vol 17, Iss 6, p e1009608 (2021)
The X-linked GRIA3 gene encodes the GLUA3 subunit of AMPA-type glutamate receptors. Pathogenic variants in this gene were previously reported in neurodevelopmental diseases, mostly in male patients but rarely in females. Here we report a de novo path
Externí odkaz:
https://doaj.org/article/7fa5280a169c4fc5a445edac625eab68
Autor:
Han Du, Chang Ye, Dan Wu, Yan-Yu Zang, Linqing Zhang, Chen Chen, Xue-Yan He, Jian-Jun Yang, Ping Hu, Zhengfeng Xu, Guoqiang Wan, Yun Stone Shi
Publikováno v:
Cell Reports, Vol 31, Iss 5, Pp - (2020)
Summary: Hypotonic stress causes the activation of swelling-activated nonselective cation channels (NSCCs), which leads to Ca2+-dependent regulatory volume decrease (RVD) and adaptive maintenance of the cell volume; however, the molecular identities
Externí odkaz:
https://doaj.org/article/45d710199b274114bdc65f57fb41701a
Autor:
Gui-Fang Duan, Yaxin Ye, Sha Xu, Wucheng Tao, Shiping Zhao, Tengchuan Jin, Roger A. Nicoll, Yun Stone Shi, Nengyin Sheng
Publikováno v:
Nature Communications, Vol 9, Iss 1, Pp 1-11 (2018)
The two kainate receptors GluK1 and GluK2 show different surface expression and synaptic trafficking. Here authors engineer chimeric GluK1-GluK2 receptors and decipher a role how the signal peptide of GluK1 behaves as a ligand of GluK1 and modifies s
Externí odkaz:
https://doaj.org/article/cc781a02cb3d418899baa57e51f71444