Zobrazeno 1 - 10
of 190
pro vyhledávání: '"Yun S Song"'
Publikováno v:
PLoS Computational Biology, Vol 19, Iss 4, p e1010137 (2023)
Addressing many of the major outstanding questions in the fields of microbial evolution and pathogenesis will require analyses of populations of microbial genomes. Although population genomic studies provide the analytical resolution to investigate e
Externí odkaz:
https://doaj.org/article/b0bc434232044bb681fca93adfebcaf0
Autor:
Olivia A Pilling, João L Reis-Cunha, Cooper A Grace, Alexander S F Berry, Matthew W Mitchell, Jane A Yu, Clara R Malekshahi, Elise Krespan, Christina K Go, Cláudia Lombana, Yun S Song, Camila F Amorim, Alexsandro S Lago, Lucas P Carvalho, Edgar M Carvalho, Dustin Brisson, Phillip Scott, Daniel C Jeffares, Daniel P Beiting
Publikováno v:
PLoS Pathogens, Vol 19, Iss 3, p e1011230 (2023)
In Brazil, Leishmania braziliensis is the main causative agent of the neglected tropical disease, cutaneous leishmaniasis (CL). CL presents on a spectrum of disease severity with a high rate of treatment failure. Yet the parasite factors that contrib
Externí odkaz:
https://doaj.org/article/737717bbee8b47e590ec22cd8859a3a4
Publikováno v:
eLife, Vol 11 (2022)
Although alternative splicing is a fundamental and pervasive aspect of gene expression in higher eukaryotes, it is often omitted from single-cell studies due to quantification challenges inherent to commonly used short-read sequencing technologies. H
Externí odkaz:
https://doaj.org/article/d0e6065bcd2d4447a1dab55d4d8a784b
Autor:
Khanh Dao Duc, Yun S Song
Publikováno v:
PLoS Genetics, Vol 14, Iss 8, p e1007620 (2018)
[This corrects the article DOI: 10.1371/journal.pgen.1007166.].
Externí odkaz:
https://doaj.org/article/eddb11ab81d947ce978bb5414a5cc718
Autor:
Khanh Dao Duc, Yun S Song
Publikováno v:
PLoS Genetics, Vol 14, Iss 1, p e1007166 (2018)
Previous studies have shown that translation elongation is regulated by multiple factors, but the observed heterogeneity remains only partially explained. To dissect quantitatively the different determinants of elongation speed, we use probabilistic
Externí odkaz:
https://doaj.org/article/fe92e74a3e6a480ebbd197a9047abdde
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 9, p e1005117 (2016)
The study of genomic regions that contain gene copies and structural variation is a major challenge in modern genomics. Unlike variation involving single nucleotide changes, data on the variation of copy number is difficult to collect and few tools e
Externí odkaz:
https://doaj.org/article/fb395b200f4f4514b2ce9c5cb1a7c954
Autor:
Sara Sheehan, Yun S Song
Publikováno v:
PLoS Computational Biology, Vol 12, Iss 3, p e1004845 (2016)
Given genomic variation data from multiple individuals, computing the likelihood of complex population genetic models is often infeasible. To circumvent this problem, we introduce a novel likelihood-free inference framework by applying deep learning,
Externí odkaz:
https://doaj.org/article/2ec9cf38b44f429a8f572837592c1f75
Publikováno v:
PLoS Genetics, Vol 11, Iss 4, p e1005069 (2015)
Genomic time series data generated by evolve-and-resequence (E&R) experiments offer a powerful window into the mechanisms that drive evolution. However, standard population genetic inference procedures do not account for sampling serially over time,
Externí odkaz:
https://doaj.org/article/b33cb61bfc604026a6a3a2b0091ba404
Publikováno v:
PLoS ONE, Vol 8, Iss 8, p e70495 (2013)
We investigate the consequences of adopting the criteria used by the state of California, as described by Myers et al. (2011), for conducting familial searches. We carried out a simulation study of randomly generated profiles of related and unrelated
Externí odkaz:
https://doaj.org/article/47ff3f030640435dacf588c11df4f720
Publikováno v:
PLoS ONE, Vol 7, Iss 11, p e46947 (2012)
Genetic exchange between isolated populations, or introgression between species, serves as a key source of novel genetic material on which natural selection can act. While detecting historical gene flow from DNA sequence data is of much interest, man
Externí odkaz:
https://doaj.org/article/f88353273d104c33926cc8e51b141500