Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression

Autor: Gloria Asantewaa, Emily T. Tuttle, Nathan P. Ward, Yun Pyo Kang, Yumi Kim, Madeline E. Kavanagh, Nomeda Girnius, Ying Chen, Katherine Rodriguez, Fabio Hecht, Marco Zocchi, Leonid Smorodintsev-Schiller, TashJaé Q. Scales, Kira Taylor, Fatemeh Alimohammadi, Renae P. Duncan, Zachary R. Sechrist, Diana Agostini-Vulaj, Xenia L. Schafer, Hayley Chang, Zachary R. Smith, Thomas N. O’Connor, Sarah Whelan, Laura M. Selfors, Jett Crowdis, G. Kenneth Gray, Roderick T. Bronson, Dirk Brenner, Alessandro Rufini, Robert T. Dirksen, Aram F. Hezel, Aaron R. Huber, Joshua Munger, Benjamin F. Cravatt, Vasilis Vasiliou, Calvin L. Cole, Gina M. DeNicola, Isaac S. Harris

Publikováno v: Nature Communications, Vol 15, Iss 1, Pp 1-18 (2024)

Abstract Cells rely on antioxidants to survive. The most abundant antioxidant is glutathione (GSH). The synthesis of GSH is non-redundantly controlled by the glutamate-cysteine ligase catalytic subunit (GCLC). GSH imbalance is implicated in many dise

Externí odkaz: https://doaj.org/article/8f2b42686a084979a860c07d826515fd

Ferroptosis in health and disease

Autor: Carsten Berndt, Hamed Alborzinia, Vera Skafar Amen, Scott Ayton, Uladzimir Barayeu, Alexander Bartelt, Hülya Bayir, Christina M. Bebber, Kivanc Birsoy, Jan P. Böttcher, Simone Brabletz, Thomas Brabletz, Ashley R. Brown, Bernhard Brüne, Giorgia Bulli, Alix Bruneau, Quan Chen, Gina M. DeNicola, Tobias P. Dick, Ayelén Distéfano, Scott J. Dixon, Jan B. Engler, Julia Esser-von Bieren, Maria Fedorova, José Pedro Friedmann Angeli, Manuel A. Friese, Dominic C. Fuhrmann, Ana J. García-Sáez, Karolina Garbowicz, Magdalena Götz, Wei Gu, Linda Hammerich, Behrouz Hassannia, Xuejun Jiang, Aicha Jeridi, Yun Pyo Kang, Valerian E. Kagan, David B. Konrad, Stefan Kotschi, Peng Lei, Marlène Le Tertre, Sima Lev, Deguang Liang, Andreas Linkermann, Carolin Lohr, Svenja Lorenz, Tom Luedde, Axel Methner, Bernhard Michalke, Anna V. Milton, Junxia Min, Eikan Mishima, Sebastian Müller, Hozumi Motohashi, Martina U. Muckenthaler, Shohei Murakami, James A. Olzmann, Gabriela Pagnussat, Zijan Pan, Thales Papagiannakopoulos, Lohans Pedrera Puentes, Derek A. Pratt, Bettina Proneth, Lukas Ramsauer, Raphael Rodriguez, Yoshiro Saito, Felix Schmidt, Carina Schmitt, Almut Schulze, Annemarie Schwab, Anna Schwantes, Mariluz Soula, Benedikt Spitzlberger, Brent R. Stockwell, Leonie Thewes, Oliver Thorn-Seshold, Shinya Toyokuni, Wulf Tonnus, Andreas Trumpp, Peter Vandenabeele, Tom Vanden Berghe, Vivek Venkataramani, Felix C.E. Vogel, Silvia von Karstedt, Fudi Wang, Frank Westermann, Chantal Wientjens, Christoph Wilhelm, Michele Wölk, Katherine Wu, Xin Yang, Fan Yu, Yilong Zou, Marcus Conrad

Publikováno v: Redox Biology, Vol 75, Iss , Pp 103211- (2024)

Ferroptosis is a pervasive non-apoptotic form of cell death highly relevant in various degenerative diseases and malignancies. The hallmark of ferroptosis is uncontrolled and overwhelming peroxidation of polyunsaturated fatty acids contained in membr

Externí odkaz: https://doaj.org/article/704bf377a6004407992c3cd92011cf30

Effectiveness of bone scans in the diagnosis of osteoarthritis of the temporomandibular joint

Autor: Kim Sg, Jo-Eun Kim, Yun Py, Kim Yk, Min Jh, Jihyeung Kim

In reference to the article by Kim et al,1 we would like to congratulate the authors on publishing an informative study. However, there are few concerns regarding this study that we would like to share with the authors. First, the authors did not men

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d04174c127e987890581d99c04fc030
https://europepmc.org/articles/PMC3528198/

Corrigendum to 'A CRISPR screen identifies redox vulnerabilities for KEAP1/NRF2 mutant non-small cell lung cancer' [Redox Biol. 54 (2022) 102358]

Autor: Chang Jiang, Nathan P. Ward, Nicolas Prieto-Farigua, Yun Pyo Kang, Anish Thalakola, Mingxiang Teng, Gina M. DeNicola

Publikováno v: Redox Biology, Vol 54, Iss , Pp 102393- (2022)

Externí odkaz: https://doaj.org/article/34ebd3e121da4bea9d0f5b58501bbd9a

Recent advances in cancer metabolism: a technological perspective

Autor: Yun Pyo Kang, Nathan P. Ward, Gina M. DeNicola

Publikováno v: Experimental and Molecular Medicine, Vol 50, Iss 4, Pp 1-16 (2018)

Cancer: Tools for mapping malignant metabolism Researchers now have access to a rapidly growing number of tools for probing the metabolic abnormalities associated with tumor growth. Unrestrained growth puts special demands on cancer cells, and scient

Externí odkaz: https://doaj.org/article/1f12fd31fd3e42779915305c36390dab