Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Yun Nan Hou"'
Autor:
Yun Nan Hou, Yang Cai, Wan Hua Li, Wei Ming He, Zhi Ying Zhao, Wen Jie Zhu, Qiang Wang, Xinyi Mai, Jun Liu, Hon Cheung Lee, Goran Stjepanovic, Hongmin Zhang, Yong Juan Zhao
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-15 (2022)
SARM1 is a key player in axon degeneration. Here, the authors generate a nanobody, which specifically recognizes the NMN-bound state of SARM1 and helps resolve the SARM1 structure in an intermediate state of activation.
Externí odkaz:
https://doaj.org/article/7ac80b9e728148edbeca55b6a3fc6886
Autor:
Wan Hua Li, Ke Huang, Yang Cai, Qian Wen Wang, Wen Jie Zhu, Yun Nan Hou, Sujing Wang, Sheng Cao, Zhi Ying Zhao, Xu Jie Xie, Yang Du, Chi-Sing Lee, Hon Cheung Lee, Hongmin Zhang, Yong Juan Zhao
Publikováno v:
eLife, Vol 10 (2021)
SARM1 regulates axonal degeneration through its NAD-metabolizing activity and is a drug target for neurodegenerative disorders. We designed and synthesized fluorescent conjugates of styryl derivative with pyridine to serve as substrates of SARM1, whi
Externí odkaz:
https://doaj.org/article/ad4f471898f24bb6b9401388eb12196c
Autor:
Dapeng Zhang, Zhi Ying Zhao, Wei Ming He, Yongjun Tan, Wan Hua Li, Yun Nan Hou, Yong Juan Zhao, Qian Wen Wang
Publikováno v:
The FEBS Journal. 288:6783-6794
SARM1, an executioner in axon degeneration, is an autoinhibitory NAD-consuming enzyme, composed of multiple domains. NMN and its analogs, CZ-48 and VMN, are the only known activators, which can release the inhibitory ARM domain from the enzymatic TIR
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::000a831c7e2fef7e272b948488fd39e5
https://doi.org/10.1111/febs.16104
https://doi.org/10.1111/febs.16104
To perform challenging visual search tasks, attention should be selectively allocated to promote targets and inhibit distractors. Rejection templates based on the distractor9s feature can be built to constrain the search process by filtering-out matc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::73dcfcf0764fbc189f2bc05e2dc0dd10
https://doi.org/10.1101/2021.07.09.451861
https://doi.org/10.1101/2021.07.09.451861
Autor:
Ke Huang, Wan Hua Li, Hon Cheung Lee, Hongmin Zhang, Yang Cai, Yun Nan Hou, Sujing Wang, Sheng Cao, Qian Wen Wang, Yang Du, Xu Jie Xie, Yong Juan Zhao, Chi-Sing Lee, Wen Jie Zhu, Zhi Ying Zhao
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::8422d24769054a8031f0db451e2ab26d
https://doi.org/10.7554/elife.67381.sa2
https://doi.org/10.7554/elife.67381.sa2
Autor:
Yun Nan Hou, Yang Du, Ke Huang, Sheng Cao, Xu Jie Xie, Hon Cheung Lee, Yang Cai, Hongmin Zhang, Wen Jie Zhu, Chi-Sing Lee, Sujing Wang, Zhi Ying Zhao, Yong Juan Zhao, Wan Hua Li, Qian Wen Wang
SARM1 regulates axonal degeneration through its NAD-metabolizing activity and is a drug target for neurodegenerative disorders. We designed and synthesized fluorescent conjugates of styryl derivative with pyridine to serve as substrates of SARM1, whi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::4c55d0c4ff02a043e1090ad4434b9585
https://doi.org/10.1101/2021.02.24.432704
https://doi.org/10.1101/2021.02.24.432704
Autor:
Cheng Wang, Yumei Chen, Yun Nan Hou, Qiufang Liu, Di Zhang, Haitao Zhao, You Zhang, Shuxian An, Lianghua Li, Jian Hou, Gang Huang, Jianjun Liu, Yong Juan Zhao, Weijun Wei
Purpose Multiple myeloma (MM) remains incurable and its diagnosis relies heavily on bone marrow aspiration and biopsy. CD38 is a glycoprotein highly specific for MM. Antibody therapeutics (e.g., daratumumab) targeting CD38 have shown encouraging effi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::9c50f90408966e14625888f80106be89
https://doi.org/10.21203/rs.3.rs-188294/v1
https://doi.org/10.21203/rs.3.rs-188294/v1
Autor:
Cheng, Wang, Yumei, Chen, Yun Nan, Hou, Qiufang, Liu, Di, Zhang, Haitao, Zhao, You, Zhang, Shuxian, An, Lianghua, Li, Jian, Hou, Gang, Huang, Jianjun, Liu, Yong Juan, Zhao, Weijun, Wei
Publikováno v:
European journal of nuclear medicine and molecular imaging. 48(9)
Multiple myeloma (MM) remains incurable and its diagnosis relies heavily on bone marrow aspiration and biopsy. CD38 is a glycoprotein highly specific for MM. Antibody therapeutics (e.g., daratumumab) targeting CD38 have shown encouraging efficacy in
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ef7ecc9bb69649a84922592301af37fd
https://pubmed.ncbi.nlm.nih.gov/33543326
https://pubmed.ncbi.nlm.nih.gov/33543326
Autor:
Huan Chen, Hon Cheung Lee, Yun Nan Hou, Na An, Ting Li, Cheng Fang, Qiong Li Zhang, Qiao Xia Zhang, Yong Juan Zhao, Xin Du
Publikováno v:
Molecular Pharmaceutics. 15:4577-4588
Chimeric antigen receptor T cells (CAR-Ts) are a promising strategy for the treatment of many cancers, including multiple myeloma (MM), a hematological malignancy characterized by the high expression of CD38. To broaden the applications of using CD38
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3fb675c8d6584997403d9174ddffb4be
https://doi.org/10.1021/acs.molpharmaceut.8b00584
https://doi.org/10.1021/acs.molpharmaceut.8b00584
Autor:
Qi Wen Deng, Ya Jie Chen, Cheng Fang, Ting Li, Yun Nan Hou, Ying Li, Hon Cheung Lee, Yong Juan Zhao, Guan Jie Xu
Publikováno v:
Journal of Biological Chemistry. 293:8151-8160
Nicotinic acid adenosine dinucleotide phosphate (NAADP) is a Ca2+-mobilizing second messenger that regulates a wide range of biological activities. However, the mechanism of its biogenesis remains controversial. CD38 is the only enzyme known to catal
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0a4a9e8d0eef9898f62d058fa9e02103
https://doi.org/10.1074/jbc.ra118.002113
https://doi.org/10.1074/jbc.ra118.002113