Zobrazeno 1 - 10
of 5 521
pro vyhledávání: '"Yun Kim"'
Publikováno v:
Journal of Cheminformatics, Vol 16, Iss 1, Pp 1-12 (2024)
Abstract The drug discovery process is demanding and time-consuming, and machine learning-based research is increasingly proposed to enhance efficiency. A significant challenge in this field is predicting whether a drug molecule’s structure will in
Externí odkaz:
https://doaj.org/article/1135195fc0644c909b882b83cfb43113
Publikováno v:
IEEE Access, Vol 11, Pp 61680-61687 (2023)
Recent advances in artificial intelligence (AI) have led to the development of transformer-based models that have shown success in identifying potential drug molecules for therapeutic purposes. However, for a molecule to be considered a viable drug c
Externí odkaz:
https://doaj.org/article/5faa288393c0435585d8e928f56730d0
Publikováno v:
Clinical and Translational Science, Vol 15, Iss 2, Pp 422-432 (2022)
Abstract Baloxavir marboxil, a novel influenza therapeutic agent, is a prodrug rapidly metabolized into its active form, baloxavir acid, which inhibits cap‐dependent endonuclease. This study evaluated the pharmacokinetics (PKs) and safety of baloxa
Externí odkaz:
https://doaj.org/article/7c565137bdd940698d474b95e0ee5d42
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-11 (2021)
The authors demonstrate a colourimetric imaging method using plasmonic nanoparticles for visualisation of heterochromatin histone markers. Based on the distance-dependent coupling effect, resulting in spectral shifts, they observe reorganisation of h
Externí odkaz:
https://doaj.org/article/236b82e720364340bdcc3a69cfe80ee0
Publikováno v:
Scientific Reports, Vol 11, Iss 1, Pp 1-9 (2021)
Abstract Chemotherapy is an important method in the field of cancer treatment and often follows surgery and/or radiotherapy to remove as many tumor cells as possible. In particular, among the chemotherapy methods, treatment using electromagnetic-base
Externí odkaz:
https://doaj.org/article/0baa56f248854cdba4bcdebfd38446eb
Publikováno v:
Life, Vol 13, Iss 1, p 100 (2022)
ALS-L1023 is an ingredient extracted from Melissa officinalis L. (Labiatae; lemon balm), which is known as a natural medicine that suppresses angiogenesis. Herein, we aimed to determine whether ALS-L1023 could alleviate liver fibrosis in the non-alco
Externí odkaz:
https://doaj.org/article/b7a285e310ee4578a3b65527f8f7cbd7
Autor:
Jiwon Bae, Ji Eun Kim, Haribalan Perumalsamy, Sehee Park, Yun Kim, Dae Won Jun, Tae Hyun Yoon
Publikováno v:
Frontiers in Immunology, Vol 13 (2022)
The number of patients with liver diseases has increased significantly with the progress of global industrialization. Hepatic fibrosis, one of the most common liver diseases diagnosed in many developed countries, occurs in response to chronic liver i
Externí odkaz:
https://doaj.org/article/6f6c0b6febe94e578ecba9fe8a9e5090
Autor:
Yoon Jin Roh, Yun Kim, Jae Sun Lee, Ju Hee Oh, Seung Min Lee, Eileen Laurel Yoon, Sung Ryol Lee, Dae Won Jun
Publikováno v:
Life, Vol 12, Iss 11, p 1682 (2022)
Hepatocyte nuclear factor 4 alpha (HNF4α) is a key master transcriptional factor for hepatic fat and bile acid metabolic pathways. We aimed to investigate the role of HNF4α in non-alcoholic fatty liver disease (NAFLD). The role of HNF4α was evalua
Externí odkaz:
https://doaj.org/article/73769bbfb1c64f56b05e146310141fc7
Publikováno v:
Journal of Personalized Medicine, Vol 12, Iss 2, p 163 (2022)
Cost-effectiveness analysis has been widely used to assess and compare the costs and benefits of a clinical service. The cost-effectiveness of vancomycin therapeutic drug monitoring (TDM) has not been studied in the elderly, who are susceptible to va
Externí odkaz:
https://doaj.org/article/3d6d39ab864542babab7e7ed0ef40e1a
Autor:
Hark Kyun Kim, Jeong Won Kang, Young‐Whan Park, Jung Young Kim, Minchae Kim, Soo Jin Kim, Se‐mi Kim, Keun Ho Ryu, Seonghae Yoon, Yun Kim, Joo‐Youn Cho, Keun Seok Lee, Tak Yun, Kiwon Kim, Mi Hyang Kwak, Tae‐Sung Kim, Jinsoo Chung, Joong‐Won Park
Publikováno v:
Pharmacology Research & Perspectives, Vol 8, Iss 2, Pp n/a-n/a (2020)
Abstract We report a phase I pharmacological study of an oral formulation of CKD‐516, a vascular‐disrupting agent, in patients with refractory solid tumors. Twenty‐seven patients (16 in the dose‐escalation cohort and 11 in the expansion cohor
Externí odkaz:
https://doaj.org/article/ccb88be43f3f4ae6a262e4a50e8c051a