Zobrazeno 1 - 10
of 37
pro vyhledávání: '"Yun Han Kwon"'
Autor:
Yun Han Kwon, Suhrid Banskota, Huaqing Wang, Laura Rossi, Jensine A. Grondin, Saad A. Syed, Yeganeh Yousefi, Jonathan D. Schertzer, Katherine M. Morrison, Michael G. Wade, Alison C. Holloway, Michael G. Surette, Gregory R. Steinberg, Waliul I. Khan
Publikováno v:
Nature Communications, Vol 13, Iss 1, Pp 1-18 (2022)
Abstract Chemicals in food are widely used leading to significant human exposure. Allura Red AC (AR) is a highly common synthetic colorant; however, little is known about its impact on colitis. Here, we show chronic exposure of AR at a dose found in
Externí odkaz:
https://doaj.org/article/e22bc7fbc4f04c989edfbdc65e3e4ed2
Autor:
Yun Han Kwon, Suhrid Banskota, Huaqing Wang, Laura Rossi, Jensine A. Grondin, Saad A. Syed, Yeganeh Yousefi, Jonathan D. Schertzer, Katherine M. Morrison, Michael G. Wade, Alison C. Holloway, Michael G. Surette, Gregory R. Steinberg, Waliul I. Khan
Publikováno v:
Nature Communications, Vol 14, Iss 1, Pp 1-1 (2023)
Externí odkaz:
https://doaj.org/article/980b7271ae484db98ed373f034b78d87
Inhibition of NADPH Oxidase (NOX) 2 Mitigates Colitis in Mice with Impaired Macrophage AMPK Function
Autor:
Suhrid Banskota, Huaqing Wang, Yun Han Kwon, Jaya Gautam, Sabah Haq, Jensine Grondin, Gregory R. Steinberg, Waliul I. Khan
Publikováno v:
Biomedicines, Vol 11, Iss 5, p 1443 (2023)
Macrophage adenosine monophosphate-activated protein kinase (AMPK) limits the development of experimental colitis. AMPK activation inhibits NADPH oxidase (NOX) 2 expression, reactive oxygen species (ROS) generation, and pro-inflammatory cytokine secr
Externí odkaz:
https://doaj.org/article/80d70e7b078c42febac98761d72c6475
Autor:
Yun Han Kwon, Huaqing Wang, Emmanuel Denou, Jean-Eric Ghia, Laura Rossi, Michelle E. Fontes, Steve P. Bernier, Md. Sharif Shajib, Suhrid Banskota, Stephen M. Collins, Michael G. Surette, Waliul I. Khan
Publikováno v:
Cellular and Molecular Gastroenterology and Hepatology, Vol 7, Iss 4, Pp 709-728 (2019)
Background & Aims: Serotonin (5-hydroxytryptamine [5-HT]) is synthesized mainly within enterochromaffin (EC) cells in the gut, and tryptophan hydroxylase 1 (Tph1) is the rate-limiting enzyme for 5-HT synthesis in EC cells. Accumulating evidence sugge
Externí odkaz:
https://doaj.org/article/277aef30894e466383b247fb23fca29b
Publikováno v:
Frontiers in Immunology, Vol 11 (2020)
Throughout the gastrointestinal (GI) tract, a distinct mucus layer composed of highly glycosylated proteins called mucins plays an essential role in providing lubrication for the passage of food, participating in cell signaling pathways and protectin
Externí odkaz:
https://doaj.org/article/d94d0cbd6fb44673af7c178d7bd52ba2
Publikováno v:
Pathogens, Vol 10, Iss 8, p 925 (2021)
Several parasites have evolved to survive in the human intestinal tract and over 1 billion people around the world, specifically in developing countries, are infected with enteric helminths. Trichuris trichiura is one of the world’s most common int
Externí odkaz:
https://doaj.org/article/1e617bc761564cc89ed8d1bd1f2a9898
Autor:
Suhrid Banskota, Hassan Brim, Yun Han Kwon, Gulshan Singh, Sidhartha R. Sinha, Huaqing Wang, Waliul I. Khan, Hassan Ashktorab
Publikováno v:
Molecules, Vol 26, Iss 11, p 3351 (2021)
Inflammatory bowel disease (IBD) is a chronic inflammatory condition of the gastrointestinal tract with an incompletely understood pathogenesis. Long-standing colitis is associated with increased risk of colon cancer. Despite the availability of vari
Externí odkaz:
https://doaj.org/article/f834c48e544843468f7cda3b7ca7db10
Autor:
Yun Han Kwon, Waliul Khan
Publikováno v:
American Journal of Physiology-Cell Physiology. 323:C550-C555
Serotonin, also known as 5-hydroxytryptamine (5-HT), is an evolutionarily ancient and phylogenetically conserved monoamine that regulates multifaceted physiological functions in mammals. 5-HT was, at one time, most extensively studied as a neurotrans
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e0e3045962bcc25086c79754913e73d
https://doi.org/10.1152/ajpcell.00433.2021
https://doi.org/10.1152/ajpcell.00433.2021
Autor:
Nicole G. Barra, Yun Han Kwon, Katherine M. Morrison, Gregory R. Steinberg, Michael G. Wade, Waliul I Khan, Mathilakath M. Vijayan, Jonathan D. Schertzer, Alison C. Holloway
Publikováno v:
American journal of physiology. Endocrinology and metabolism. 323(1)
Obesogens are synthetic, environmental chemicals that can disrupt endocrine control of metabolism and contribute to the risk of obesity and metabolic disease. Bisphenol A (BPA) is one of the most studied obesogens. There is considerable evidence that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::137ad72993634529d69b69f3059a82f0
https://pubmed.ncbi.nlm.nih.gov/35575233
https://pubmed.ncbi.nlm.nih.gov/35575233
Autor:
Yun Han Kwon, Gregory R. Steinberg, Sabah Haq, Usha Chauhan, John H. Brumell, Francine Côté, Jensine Grondin, John Marshall, Huaqing Wang, Waliul I. Khan, Michael G. Surette, Suhrid Banskota, Irfan I. Khan, Dana J. Philpott
Publikováno v:
Science Advances
Science Advances, American Association for the Advancement of Science (AAAS), 2021, 7 (45), ⟨10.1126/sciadv.abi6442⟩
Science Advances, American Association for the Advancement of Science (AAAS), 2021, 7 (45), ⟨10.1126/sciadv.abi6442⟩
Description
Elevated gut serotonin inhibits autophagy via mTOR promoting a disrupted microbiota and enhanced susceptibility to colitis.
Autophagy, an essential intracellular recycling process, is linked to the pathogenesis of various diseas
Elevated gut serotonin inhibits autophagy via mTOR promoting a disrupted microbiota and enhanced susceptibility to colitis.
Autophagy, an essential intracellular recycling process, is linked to the pathogenesis of various diseas
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d38dadaa504907dcbb0f0e3f2aae5850
https://hal.archives-ouvertes.fr/hal-03443947
https://hal.archives-ouvertes.fr/hal-03443947
