Homologated amino acids with three vicinal fluorines positioned along the backbone: development of a stereoselective synthesis

Autor: Raju Cheerlavancha, Ahmed Ahmed, Yun Cheuk Leung, Aggie Lawer, Qing-Quan Liu, Marina Cagnes, Hee-Chan Jang, Xiang-Guo Hu, Luke Hunter

Publikováno v: Beilstein Journal of Organic Chemistry, Vol 13, Iss 1, Pp 2316-2325 (2017)

Backbone-extended amino acids have a variety of potential applications in peptide and protein science, particularly if the geometry of the amino acid is controllable. Here we describe the synthesis of δ-amino acids that contain three vicinal C–F b

Externí odkaz: https://doaj.org/article/8f6f4ba5619d414e9591e238346ecde5

Tuning the properties of a cyclic RGD-containing tetrapeptide through backbone fluorination

Autor: Zhiyong Wang, Eddy Pasquier, Flora Mansour, Renate Griffith, Xiang-Guo Hu, Yun Cheuk Leung, Luke Hunter, Johny Trinh, Christina Gonzalez, Catherine Au

Publikováno v: Organic and Biomolecular Chemistry
Organic and Biomolecular Chemistry, Royal Society of Chemistry, 2019, 17 (3), pp.664-674. ⟨10.1039/c8ob02679c⟩
Organic & Biomolecular Chemistry
Organic & Biomolecular Chemistry, 2019, 17 (3), pp.664-674. ⟨10.1039/c8ob02679c⟩

International audience; Stereoselective fluorination is investigated as a method for modulating the properties of a cyclic RGD-containing tetrapeptide. Three key outcomes of fluorination are assessed: (i) the effect on peptide cyclisation efficiency;

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f3b393b5a8b17f606106d8d1ed5ac912
https://hal.archives-ouvertes.fr/hal-02503849

Synthesis of a Novel Library of 1-Substituted Pyrido[1,2-a]benzimidazoles

Autor: Mohan Bhadbade, Satyanarayana Gadde, Naresh Kumar, David StC. Black, Yun Cheuk Leung, Belamy B. Cheung

Publikováno v: Australian Journal of Chemistry. 73:1208

The reactivity and synthesis of new analogues of pyrido[1,2-a]benzimidazoles have been explored. Twenty-three derivatives bearing phenoxy, thiophenoxy, aniline, and aryl groups at the 1-position were successfully synthesised in 25–91% yield, via nu

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::d53a2192492f263f095292743dbf55c1
https://doi.org/10.1071/ch20173

Predicting Octanol–Water Partition Coefficients of Fluorinated Drug-Like Molecules: A Combined Experimental and Theoretical Study.

Autor: Wu, Ying Min¹ (AUTHOR), Salas, Yuvixza Lizarme¹ (AUTHOR), Leung, Yun Cheuk¹ (AUTHOR), Hunter, Luke¹ (AUTHOR) l.hunter@unsw.edu.au, Ho, Junming¹ (AUTHOR) junming.ho@unsw.edu.au

Publikováno v: Australian Journal of Chemistry. 2020, Vol. 73 Issue 8, p677-685. 9p.

Tuning the properties of a cyclic RGD-containing tetrapeptide through backbone fluorination.

Autor: Au, Catherine, Gonzalez, Christina, Leung, Yun Cheuk, Mansour, Flora, Trinh, Johny, Wang, Zhiyong, Hu, Xiang-Guo, Griffith, Renate, Pasquier, Eddy, Hunter, Luke

Publikováno v: Organic & Biomolecular Chemistry; 1/21/2019, Vol. 17 Issue 3, p664-674, 11p