Systematic analysis of concentrations of 52 elements in tumor and counterpart normal tissues of patients with non‐small cell lung cancer

Autor: Xin Cheng, Yong‐Chun Zhou, Bo Zhou, Yun‐Chao Huang, Gui‐Zhen Wang, Guang‐Biao Zhou

Publikováno v: Cancer Medicine, Vol 8, Iss 18, Pp 7720-7727 (2019)

Abstract Background Many studies have documented the abnormal concentrations of major/trace elements in serum or malignant tissues of patients, but very few works systematically tested the concentrations of elements in tumor tissues in comparison wit

Externí odkaz: https://doaj.org/article/49ca8f16de71483986081efb0fdd79bb

What are the clinical symptoms and physical signs for non‐small cell lung cancer before diagnosis is made? A nation‐wide multicenter 10‐year retrospective study in China

Autor: Pu‐Yuan Xing, Yi‐Xiang Zhu, Le Wang, Zhou‐Guang Hui, Shang‐Mei Liu, Jian‐Song Ren, Ye Zhang, Yan Song, Cheng‐Cheng Liu, Yun‐Chao Huang, Xian‐Zhen Liao, Xiao‐Jing Xing, De‐Bin Wang, Li Yang, Ling‐Bin Du, Yu‐Qin Liu, Yong‐Zhen Zhang, Yun‐Yong Liu, Dong‐Hua Wei, Kai Zhang, Ju‐Fang Shi, You‐Lin Qiao, Wan‐Qing Chen, Jun‐Ling Li, Min Dai, the LuCCRES Group

Publikováno v: Cancer Medicine, Vol 8, Iss 8, Pp 4055-4069 (2019)

Abstract Background Most lung cancer patients are diagnosed after the onset of symptoms. However, whether the symptoms of lung cancer were independently associated with the diagnosis of lung cancer is unknown, especially in the Chinese population. Me

Externí odkaz: https://doaj.org/article/9d08303fe1624fb89616cee886fc541a

The Aryl hydrocarbon receptor mediates tobacco-induced PD-L1 expression and is associated with response to immunotherapy

Autor: Gui-Zhen Wang, Li Zhang, Xin-Chun Zhao, San-Hui Gao, Li-Wei Qu, Hong Yu, Wen-Feng Fang, Yong-Chun Zhou, Fan Liang, Chen Zhang, Yun-Chao Huang, Zhihua Liu, Yang-Xin Fu, Guang-Biao Zhou

Publikováno v: Nature Communications, Vol 10, Iss 1, Pp 1-13 (2019)

Lung cancer patients who smoke show a better response to immunotherapy than non-smokers. Here, the authors show that tobacco smoke induces PD-L1 expression on lung epithelial cells via AhR that is associated with benefits of PD-1 inhibitor in patient

Externí odkaz: https://doaj.org/article/d371cb011e6b4efbb2eef8fc2a22dd28

Systematic identification of CDC34 that functions to stabilize EGFR and promote lung carcinogenesis

Autor: Xin-Chun Zhao, Gui-Zhen Wang, Zhe-Sheng Wen, Yong-Chun Zhou, Qian Hu, Bin Zhang, Li-Wei Qu, San-Hui Gao, Jie Liu, Liang Ma, Yan-Fei Zhang, Chen Zhang, Hong Yu, Da-Lin Zhang, Min Wang, Chang-Li Wang, Yun-Chao Huang, Zhi-hua Liu, Yong Zhao, Liang Chen, Guang-Biao Zhou

Publikováno v: EBioMedicine, Vol 53, Iss , Pp - (2020)

Background: How the oncoprotein epidermal growth factor receptor (EGFR) evades proteolytic degradation and accumulates in non-small cell lung cancer (NSCLC) remains unclear, and ubiquitin pathway genes (UPGs) that are critical to NSCLC needs to be sy

Externí odkaz: https://doaj.org/article/24484073cb9c461a9d071eb6d3df48f5

Tuberculosis infection and lung adenocarcinoma: Mendelian randomization and pathway analysis of genome-wide association study data from never-smoking Asian women

Autor: Jason Y.Y. Wong, Han Zhang, Chao A. Hsiung, Kouya Shiraishi, Kai Yu, Keitaro Matsuo, Maria Pik Wong, Yun-Chul Hong, Jiucun Wang, Wei Jie Seow, Zhaoming Wang, Minsun Song, Hee Nam Kim, I-Shou Chang, Nilanjan Chatterjee, Wei Hu, Chen Wu, Tetsuya Mitsudomi, Wei Zheng, Jin Hee Kim, Adeline Seow, Neil E. Caporaso, Min-Ho Shin, Lap Ping Chung, She-Juan An, Ping Wang, Yang Yang, Hong Zheng, Yasushi Yatabe, Xu-Chao Zhang, Young Tae Kim, Qiuyin Cai, Zhihua Yin, Young-Chul Kim, Bryan A. Bassig, Jiang Chang, James Chung Man Ho, Bu-Tian Ji, Yataro Daigo, Hidemi Ito, Yukihide Momozawa, Kyota Ashikawa, Yoichiro Kamatani, Takayuki Honda, H. Dean Hosgood, Hiromi Sakamoto, Hideo Kunitoh, Koji Tsuta, Shun-ichi Watanabe, Michiaki Kubo, Yohei Miyagi, Haruhiko Nakayama, Shingo Matsumoto, Masahiro Tsuboi, Koichi Goto, Jianxin Shi, Lei Song, Xing Hua, Atsushi Takahashi, Akiteru Goto, Yoshihiro Minamiya, Kimihiro Shimizu, Kazumi Tanaka, Fusheng Wei, Fumihiko Matsuda, Jian Su, Yeul Hong Kim, In-Jae Oh, Fengju Song, Wu-Chou Su, Yu-Min Chen, Gee-Chen Chang, Kuan-Yu Chen, Ming-Shyan Huang, Li-Hsin Chien, Yong-Bing Xiang, Jae Yong Park, Sun-Seog Kweon, Chien-Jen Chen, Kyoung-Mu Lee, Batel Blechter, Haixin Li, Yu-Tang Gao, Biyun Qian, Daru Lu, Jianjun Liu, Hyo-Sung Jeon, Chin-Fu Hsiao, Jae Sook Sung, Ying-Huang Tsai, Yoo Jin Jung, Huan Guo, Zhibin Hu, Wen-Chang Wang, Charles C. Chung, Laurie Burdett, Meredith Yeager, Amy Hutchinson, Sonja I. Berndt, Wei Wu, Herbert Pang, Yuqing Li, Jin Eun Choi, Kyong Hwa Park, Sook Whan Sung, Li Liu, C.H. Kang, Meng Zhu, Chung-Hsing Chen, Tsung-Ying Yang, Jun Xu, Peng Guan, Wen Tan, Chih-Liang Wang, Michael Hsin, Ko-Yung Sit, James Ho, Ying Chen, Yi Young Choi, Jen-Yu Hung, Jun Suk Kim, Ho Il Yoon, Chien-Chung Lin, In Kyu Park, Ping Xu, Yuzhuo Wang, Qincheng He, Reury-Perng Perng, Chih-Yi Chen, Roel Vermeulen, Junjie Wu, Wei-Yen Lim, Kun-Chieh Chen, Yao-Jen Li, Jihua Li, Hongyan Chen, Chong-Jen Yu, Li Jin, Tzu-Yu Chen, Shih-Sheng Jiang, Jie Liu, Taiki Yamaji, Belynda Hicks, Kathleen Wyatt, Shengchao A. Li, Juncheng Dai, Hongxia Ma, Guangfu Jin, Bao Song, Zhehai Wang, Sensen Cheng, Xuelian Li, Yangwu Ren, Ping Cui, Motoki Iwasaki, Taichi Shimazu, Shoichiro Tsugane, Junjie Zhu, Kaiyun Yang, Gening Jiang, Ke Fei, Guoping Wu, Hsien-Chin Lin, Hui-Ling Chen, Yao-Huei Fang, Fang-Yu Tsai, Wan-Shan Hsieh, Jinming Yu, Victoria L. Stevens, Ite A. Laird-Offringa, Crystal N. Marconett, Linda Rieswijk, Ann Chao, Pan-Chyr Yang, Xiao-Ou Shu, Tangchun Wu, Y.L. Wu, Dongxin Lin, Kexin Chen, Baosen Zhou, Yun-Chao Huang, Takashi Kohno, Hongbing Shen, Stephen J. Chanock, Nathaniel Rothman, Qing Lan

Publikováno v: Genomics, 112(2), 1223. Academic Press Inc.
Genomics, 112(2), 1223-1232. Academic Press Inc.
Genomics

We investigated whether genetic susceptibility to tuberculosis (TB) influences lung adenocarcinoma development among never-smokers using TB genome-wide association study (GWAS) results within the Female Lung Cancer Consortium in Asia. Pathway analysi

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::99b3e9bd337a2961f1186b92ef9aec4d
https://doi.org/10.1016/j.ygeno.2019.07.008