Normal human pluripotent stem cell lines exhibit pervasive mosaic aneuploidy.

Autor: Suzanne E Peterson, Jurjen W Westra, Stevens K Rehen, Holly Young, Diane M Bushman, Christine M Paczkowski, Yun C Yung, Candace L Lynch, Ha T Tran, Kyle S Nickey, Yu-Chieh Wang, Louise C Laurent, Jeanne F Loring, Melissa K Carpenter, Jerold Chun

Publikováno v: PLoS ONE, Vol 6, Iss 8, p e23018 (2011)

Human pluripotent stem cell (hPSC) lines have been considered to be homogeneously euploid. Here we report that normal hPSC--including induced pluripotent--lines are karyotypic mosaics of euploid cells intermixed with many cells showing non-clonal ane

Externí odkaz: https://doaj.org/article/d2ba257e2f15481f86a4b1b0c20a9ba5

X-linked hydrocephalus genes: Their proximity to telomeres and high A + T content compared to Parkinson's disease

Autor: Madeline Hart, Joshua Conrad, Emma Barrett, Kaitlyn Legg, Gabrielle Ivey, Peter H.U. Lee, Yun C. Yung, Joon W. Shim

Publikováno v: Experimental Neurology. 366:114433

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::b5b1dcb4511efeaa0b3028e67a8c58ad
https://doi.org/10.1016/j.expneurol.2023.114433

Opportunities in posthemorrhagic hydrocephalus research: outcomes of the Hydrocephalus Association Posthemorrhagic Hydrocephalus Workshop

Autor: Richard F. Keep, Jill A. Morris, James P. McAllister, Jenna E. Koschnitzky, Yun C. Yung, Jennifer Strahle, David D. Limbrick

Publikováno v: Fluids and Barriers of the CNS, Vol 15, Iss 1, Pp 1-22 (2018)
Fluids and Barriers of the CNS

The Hydrocephalus Association Posthemorrhagic Hydrocephalus Workshop was held on July 25 and 26, 2016 at the National Institutes of Health. The workshop brought together a diverse group of researchers including pediatric neurosurgeons, neurologists,

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fa06a8250ef6a83fc439fecb4989966b
http://link.springer.com/article/10.1186/s12987-018-0096-3

Integrative single-cell analysis of transcriptional and epigenetic states in the human adult brain

Autor: Gwendolyn E. Kaeser, Jean Fan, Brandon C. Sos, Kun Zhang, Derek Gao, Thu Elizabeth Duong, Yun C. Yung, Peter V. Kharchenko, Jerold Chun, Blue B. Lake, Song Chen

Publikováno v: Nature biotechnology, vol 36, iss 1
Nature biotechnology

Detailed characterization of the cell types in the human brain requires scalable experimental approaches to examine multiple aspects of the molecular state of individual cells, as well as computational integration of the data to produce unified cell-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e141bb798d2fedfac7e2c8fbf529bbd
https://pubmed.ncbi.nlm.nih.gov/29319686

Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain

Autor: Ho-Lim Fung, Xiaoyan Sheng, Kun Zhang, Richard Shen, Julian Wong, Jerold Chun, Andre Wildberg, Wei Wang, Fiona Kaper, Derek Gao, Rizi Ai, Jian-Bing Fan, Rui Liu, Blue B. Lake, Neeraj Salathia, Yun C. Yung, Mostafa Ronaghi, Allison Chen, Gwendolyn E. Kaeser, Raakhee Vijayaraghavan, Song Chen

Publikováno v: Science (New York, N.Y.), vol 352, iss 6293
Lake, BB; Ai, R; Kaeser, GE; Salathia, NS; Yung, YC; Liu, R; et al.(2016). Neuronal subtypes and diversity revealed by single-nucleus RNA sequencing of the human brain. SCIENCE, 352(6293), 1586-1590. doi: 10.1126/science.aaf1204. UC San Diego: Retrieved from: http://www.escholarship.org/uc/item/7tp2q0jr

Single-nucleus gene expression Identifying the genes expressed at the level of a single cell nucleus can better help us understand the human brain. Blue et al. developed a single-nuclei sequencing technique, which they applied to cells in classically

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d7c45b3bea607e2f560162accb37c970
https://escholarship.org/uc/item/7tp2q0jr