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of 100
pro vyhledávání: '"Yun‐Xin Fu"'
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 4, p 4237 (2023)
The indispensable role of the SARS-CoV-2 main protease (Mpro) in the viral replication cycle and its dissimilarity to human proteases make Mpro a promising drug target. In order to identify the non-covalent Mpro inhibitors, we performed a comprehensi
Externí odkaz:
https://doaj.org/article/e800cf05d8894e78bbe531240df8db3f
Autor:
Xiaoming Liu, Yun-Xin Fu
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-9 (2020)
Abstract Inferring the demographic histories of populations has wide applications in population, ecological, and conservation genomics. We present Stairway Plot 2, a cross-platform program package for this task using SNP frequency spectra. It is base
Externí odkaz:
https://doaj.org/article/3b3b6c092b3140519eade79d409b4853
Publikováno v:
ACS Omega, Vol 5, Iss 39, Pp 25077-25086 (2020)
Externí odkaz:
https://doaj.org/article/54d364deffcd471f91052284b2b8fa18
Publikováno v:
Cells, Vol 11, Iss 8, p 1274 (2022)
The receptor-binding domain (RBD) of the SARS-CoV-2 spike protein (RBDCoV2) has a higher binding affinity to the human receptor angiotensin-converting enzyme 2 (ACE2) than the SARS-CoV RBD (RBDCoV). Here, we performed molecular dynamics (MD) simulati
Externí odkaz:
https://doaj.org/article/b98836cc71d540a4864b7c87c8f8f291
Publikováno v:
Theoretical Population Biology. 145:52-62
Cell division is a necessity of life which can be either mitotic or amitotic. While both are fundamental, amitosis is sometimes considered a relic of little importance in biology. Nevertheless, eukaryotes often have polyploid cells, including cancer
Publikováno v:
International Journal of Molecular Sciences, Vol 22, Iss 4, p 1781 (2021)
Cold-adapted enzymes feature a lower thermostability and higher catalytic activity compared to their warm-active homologues, which are considered as a consequence of increased flexibility of their molecular structures. The complexity of the (thermo)s
Externí odkaz:
https://doaj.org/article/7333e91d45a44ae291db63034c1accbb
Autor:
Xiaoming Liu, Yun-Xin Fu
Publikováno v:
Genome Biology, Vol 21, Iss 1, Pp 1-1 (2020)
An amendment to this paper has been published and can be accessed via the original article.
Externí odkaz:
https://doaj.org/article/4dd8262635f240ccb5ca900f4311b14c
Autor:
Wangjie Hu, Ziqian Hao, Pengyuan Du, Di Vincenzo, Fabio, Manzi, Giorgio, Jialong Cui, Yun-Xin Fu, Yi-Hsuan Pan, Haipeng Li
Publikováno v:
Science; 9/1/2023, Vol. 381 Issue 6661, p979-984, 6p, 5 Diagrams
Autor:
Yun-Xin Fu
Publikováno v:
Theor Popul Biol
Each mutation in a population sample of DNA sequences can be classified by the number of sequences that inherit the mutant nucleotide, the resulting frequencies are known as mutations of different sizes or site frequency spectrum. Many summary statis
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0ba55dc2840c16b37cbd5eb8dc17ba90
https://europepmc.org/articles/PMC9584357/
https://europepmc.org/articles/PMC9584357/
Publikováno v:
PLoS ONE, Vol 10, Iss 8, p e0135398 (2015)
Mutation primarily occurs when cells divide and it is highly desirable to have knowledge of the rate of mutations for each of the cell divisions during individual development. Recently, recessive lethal or nearly lethal mutations which were observed
Externí odkaz:
https://doaj.org/article/db0e9fa0e9b34c42b6df522765d76aad