Zobrazeno 1 - 10
of 14
pro vyhledávání: '"Yumiko Sekiya"'
Autor:
Yumiko Sekiya, Kaoru Shimada, Hiroshi Takahashi, Chisa Kuga, Shunsuke Komachi, Keishi Miwa, Toru Kotani
Publikováno v:
Intensive Care Medicine Experimental, Vol 9, Iss 1, Pp 1-14 (2021)
Abstract Background Platelet–neutrophil complexes (PNCs) readily migrate into tissues and induce tissue damage via cytokine or other pathogenic factors release. These actions are involved in onset and progression of acute respiratory distress syndr
Externí odkaz:
https://doaj.org/article/1bba598c66f34068bb399765299fbcfe
Autor:
Yumiko Sekiya, Hiroshi Takahashi, Toru Kotani, Chisa Kuga, Keishi Miwa, Kaoru Shimada, Shunsuke Komachi
Background: Neutrophil-platelet complexes (NPCs) readily migrate into tissues and induce tissue damage via cytokine or other pathogenic factors release. These actions are involved in onset and progression of acute respiratory distress syndrome (ARDS)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::109f4016f447e4bc7b918bc708b26610
https://doi.org/10.21203/rs.3.rs-558676/v1
https://doi.org/10.21203/rs.3.rs-558676/v1
Autor:
Yosuke Niimi, Perenlei Enkhbaatar, Toru Kotani, Ennert Manyeza, Donald S. Prough, Satoshi Fukuda, Robert H. Cox, Yumiko Sekiya, Gilbert Ryan, Sam Jacob
Publikováno v:
Critical Care Medicine. 48:533-533
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::d6b115c46f44c8468604c2e1996a9756
https://doi.org/10.1097/01.ccm.0000643368.06674.85
https://doi.org/10.1097/01.ccm.0000643368.06674.85
Autor:
Yumiko Sekiya, Satoshi Sakami, Hiroki Kumagai, Takehiro Takahashi, Koji Kawai, Aiko Nitta, Seiji Okazaki, Tomokatsu Iwamura, Mikiya Sato, Mai Yagi, Junko Nakaki, Mie Kainoh
Publikováno v:
Journal of Pharmacology and Experimental Therapeutics. 351:181-189
11β-Hydroxysteroid dehydrogenase type 1 (11β-HSD1) is considered a potential therapeutic target in the treatment of type 2 diabetes mellitus. In this study, we investigated the pharmacological properties of HIS-388 (N-[(1R,2s,3S,5s,7s)-5-hydroxyada
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4343d213f7c0b52127ad7674491eae72
https://doi.org/10.1124/jpet.114.216556
https://doi.org/10.1124/jpet.114.216556
Autor:
Shinichi Yamaguchi, Kazuharu Suyama, Kazumi Nishimura, Hiroshi Ueda, Yosuke Iura, Masateru Yamada, Toshiya Takahashi, Shigeo Fujii, Nobuhiro Fuchi, Aiko Nitta, Hiroaki Kaneko, Yumiko Sekiya
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:4358-4361
We report the discovery and structure–activity relationship of 2,6-disubstituted pyrazines, which are potent and selective CK2 inhibitors. Lead compound 1 was identified, and derivatives were prepared to develop potent inhibitory activity. As a res
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::40b789b97df6e6cb81f046a6f856730e
https://doi.org/10.1016/j.bmcl.2012.05.006
https://doi.org/10.1016/j.bmcl.2012.05.006
Autor:
Norifumi Kawada, Tomohiro Ogawa, Katsutoshi Yoshizato, Kazuo Ikeda, Masaru Enomoto, Yumiko Sekiya, Hideki Fujii
Publikováno v:
Gut. 61:1600-1609
Background MicroRNAs (miRNAs) are important in hepatic pathophysiology and the development of liver cancer. Objective To explore miRNAs that are regulated with the progression of liver fibrosis caused by chronic liver disease. Design The regulated mi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0e31738fc1e2e016624b6a5bc6bdac8f
https://doi.org/10.1136/gutjnl-2011-300717
https://doi.org/10.1136/gutjnl-2011-300717
Autor:
Le Thi Thanh Thuy, Masashi Iizuka, Norifumi Kawada, Kenichi Wakasa, Kazuo Ikeda, Takashi Morita, Shinobu Momen, Hiroyuki Motoyama, Katsutoshi Yoshizato, Mami Mori, Kayo Yoshida, Tomohiro Ogawa, Yumiko Sekiya
Publikováno v:
The American Journal of Pathology. 179:1050-1060
Cytoglobin (Cygb) is a recently discovered vertebrate globin with molecular characteristics that are similar to myoglobin. To study the biological function of Cygb in vivo, we generated Cygb knockout mice and investigated their susceptibility to N,N-
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6f051e7e37550229bbccdc8343c76a26
https://doi.org/10.1016/j.ajpath.2011.05.006
https://doi.org/10.1016/j.ajpath.2011.05.006
Publikováno v:
Biochemical and Biophysical Research Communications. 412:74-79
MicroRNAs (miRNAs) participate in the regulation of cellular functions including proliferation, apoptosis, and migration. It has been previously shown that the miR-29 family is involved in regulating type I collagen expression by interacting with the
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c7bfc6c30fb9cee6d7fcce24be785958
https://doi.org/10.1016/j.bbrc.2011.07.041
https://doi.org/10.1016/j.bbrc.2011.07.041
Autor:
Tomohiro Ogawa, Norifumi Kawada, Kazuo Ikeda, Masashi Iizuka, Yumiko Sekiya, Katsutoshi Yoshizato
Publikováno v:
Journal of Cellular Physiology. 226:2535-2542
Recent studies have suggested that interferons (IFNs) have an antifibrotic effect in the liver independent of their antiviral effect although its detailed mechanism remains largely unknown. Some microRNAs have been reported to regulate pathophysiolog
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::1b3fc2c85d2f87d4ecc0f4e60ce7d12b
https://doi.org/10.1002/jcp.22598
https://doi.org/10.1002/jcp.22598
Autor:
Norifumi Kawada, Masashi Iizuka, Yumiko Sekiya, Kazuo Ikeda, Katsutoshi Yoshizato, Tomohiro Ogawa
Publikováno v:
Biochemical and Biophysical Research Communications. 391:316-321
MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression through imperfect base pairing with the 3' untranslated region (3'UTR) of target mRNA. We studied the regulation of alpha 1 (I) collagen (Col1A1) expression by miRNAs in human
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c9902a7ddf4ee768707ebb3b8a65451
https://doi.org/10.1016/j.bbrc.2009.11.056
https://doi.org/10.1016/j.bbrc.2009.11.056