Výsledky vyhledávání - "Yumiko Sakakibara"

Effects of (+)-, (-)- and (.+-.)-Indenestrols A and B on Microtubule Polymerization

Autor: Taiko Oda, Tadashi Hata, Yumiko Sakakibara, Hiroyuki Hanzawa, Yoshihiro Sato

Publikováno v: Chemical and Pharmaceutical Bulletin. 40:588-592

Indenestrol A (IA) is a metabolite of diethylstilbestrol (DES), and indenestrol B (IB) is an analog of IA. IA was simply obtained from E,E-dienestrol in the presence of dilute sulfuric acid, and a mixture of IA and IB was formed by thermal cyclizatio

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9114edea59d4a38233df1b596f32f11b
https://doi.org/10.1248/cpb.40.588

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Effects of synthetic estrogens, (R,R)-(+)-, (S,S)-(−)-, dl- and meso-hexestrol stereoisomers on microtubule assembly

Autor: Kiyoshi Hasegawa, Aiko Hirata, Taiko Oda, Yoshihiro Sato, Michio Matsuhashi, Yumiko Sakakibara, Hazime Saitô, Masahiko Kodama

Publikováno v: Biochemical Pharmacology. 39:167-172

We previously reported on the inhibition of microtubule polymerization and the formation of ribbon structures by synthetic estrogens [Sato et al., J Biochem101: 1247–1252, 1987]. The present investigation aimed to analyse these effects in vitro on

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffddf31022eb866a5ec828043f6b721d
https://doi.org/10.1016/0006-2952(90)90661-4

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Effect of meso-hexestrol, a synthetic estrogen, on S-tubulin

Autor: Taiko Oda, Michio Matsuhashi, Yumiko Sakakibara, Aiko Hirata, Yoshihiro Sato

Publikováno v: Chemical and Pharmaceutical Bulletin. 38:3419-3422

We have reported that meso-hexestrol, a synthetic estrogen, inhibits microtubule assembly and induces microtubule proteins into twisted ribbon structures. On the other hand, Serrano et al. proved that S-tubulin, which lacks the C-terminal moiety of t

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6107b638427665db4a478bee73ba9256
https://doi.org/10.1248/cpb.38.3419

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Effects of some diethylstilbestrol metabolites and analogs on cytotoxicity and aneuploidy induction in Chinese hamster V79 cells

Autor: Yoshihiro Sato, Taiko Oda, Mitsuru Watanuki, Yumiko Sakakibara

Publikováno v: Biologicalpharmaceutical bulletin. 18(10)

We have previously reported the inhibitory effects of diethylstilbestrol (1) and optically active indenestrol derivatives on microtubule polymerization in vitro and their disruptive effect on cytoplasmic microtubules and cytotoxicity in cultured Chin

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac0c4639d5087362ade29285af1cfd4
https://pubmed.ncbi.nlm.nih.gov/8593451

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Effects of (+)-, (-)- and (+/-)-indenestrols A and B on microtubule distribution and cytotoxicity in Chinese hamster V79 cells

Autor: Eriko Aizu-Yokota, Ken Ichinoseki, Yoshihiro Sato, Yumiko Sakakibara, Taiko Oda

Publikováno v: Mutation research. 289(2)

We have reported that (+)-, (−)- and (±)-indenestrols A and B (IA and IB respectively) inhibit the polymerization of microtubule proteins isolated from porcine brain in vitro. In this study, the effects of (+)-, (−)- and (±)-IA and IB on the re

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4735b0424e0dfff6e09d9dafc386d612
https://pubmed.ncbi.nlm.nih.gov/7690891

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Effects of 32-oxygenated lanosterol derivatives on 3-hydroxy-3-methylglutaryl coenzyme A reductase activity and cholesterol biosynthesis from 24,25-dihydrolanosterol

Autor: Yoshihiro Sato, Masako Onoda, Yumiko Sakakibara, Yoshiko Sonoda, Noriko Obi

Publikováno v: Chemicalpharmaceutical bulletin. 40(10)

The effects of 32-oxygenated lanosterol derivatives on 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity and cholesterol biosynthesis from [24,25-3H]24,25-dihydrolanosterol were studied. Among the derivatives, 3 beta-hydroxylanost-7-

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc1bbed4557c831ff3e3a7661cf54a5b
https://pubmed.ncbi.nlm.nih.gov/1464112

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Effects of 3,3'-dihydroxy-alpha,beta-diethylstilbene and 3,3',4,5'-tetrahydroxystilbene on microtubule assembly in vitro, aneuploidy induction, and cellular microtubule and actin networks

Autor: Hiroshi Tsujibo, Yoshihiro Sato, Izumi Saito, Yoshihiko Inamori, Taiko Oda, Yumiko Sakakibara

Publikováno v: Chemicalpharmaceutical bulletin. 40(8)

We examined the inhibitory activities of 3,3'-dihydroxy-alpha,beta-diethylstilbene (DDS) and 3,3',4,5'-tetrahydroxystilbene (THS) on microtubule assembly in vitro and their effects on chromosome number and cellular microtubule networks in Chinese ham

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::71d4382231fc40c6ca2d0ce55508951e
https://pubmed.ncbi.nlm.nih.gov/1423765

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