Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Yumiko Moritani"'
Autor:
Yoshiyuki Iwatsuki, Tomihisa Kawasaki, Chinatsu Sakata, Yumiko Moritani, Yoshiaki Morita, Hideaki Hara
Publikováno v:
Thrombosis research. 157
Introduction Percutaneous coronary interventions (PCIs), such as balloon angioplasty and stent placement, are effective in the treatment of coronary artery disease. PCI has drawbacks, however, including acute thrombosis after the procedure and resten
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5008b8c98ade3849c7f5efe6ef2daec2
https://pubmed.ncbi.nlm.nih.gov/28700965
https://pubmed.ncbi.nlm.nih.gov/28700965
Autor:
Yuzo Matsumoto, Yuji Koga, Norio Seki, Kenichi Mori, Tsukasa Ishihara, Yumiko Moritani, Ryouta Shiraki, Takeshi Kadokura, Yoshiyuki Iwatsuki, Shuichi Sakamoto, Takeshi Shigenaga, Hiroyuki Koshio, Keizo Sugasawa, Shunichiro Hachiya, Fukushi Hirayama, Shin-ichi Tsukamoto, Tomihisa Kawasaki
Publikováno v:
Journal of Medicinal Chemistry. 54:8051-8065
Inhibitors of factor Xa (FXa), a crucial serine protease in the coagulation cascade, have attracted a great deal of attention as a target for developing antithrombotic agents. We previously reported findings from our optimization study of a high-thro
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c8a6c40b5439d83acb06a80b263695a
https://doi.org/10.1021/jm200868m
https://doi.org/10.1021/jm200868m
Autor:
Keiji Miyata, Kazumi Hayashi, Tomihisa Kawasaki, Tetsu Saito, Jun Takasaki, Yumiko Moritani, Masatoshi Taniguchi, Wataru Uchida, Toshio Uemura
Publikováno v:
British Journal of Pharmacology. 148:61-69
1 The effects of YM-254890, a specific Galpha(q/11) inhibitor, on platelet functions, thrombus formation under high-shear rate condition and femoral artery thrombosis in cynomolgus monkeys were investigated. 2 YM-254890 concentration dependently inhi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0c02902a40dd0186b3df7d61def551a7
https://doi.org/10.1038/sj.bjp.0706711
https://doi.org/10.1038/sj.bjp.0706711
Autor:
Kazuo Sato, Naoko Katayama, Tsukasa Ishihara, Yuzo Matsumoto, Yumiko Moritani, Fukushi Hirayama, Shin-ichi Tsukamoto, Yoshiyuki Iwatsuki, Shuichi Sakamoto, Hiroyuki Koshio, Tomihisa Kawasaki, Takeshi Shigenaga, Seiji Kaku, Yuta Taniuchi, Ryouta Shiraki
Publikováno v:
Bioorganic & Medicinal Chemistry. 13:1305-1323
Factor Xa (fXa) is a serine protease that plays a pivotal role in the coagulation cascade. High-throughput screening of the Yamanouchi compound library yielded lead compound 1 with the ability to inhibit fXa at micromolar concentrations. To improve i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::d91adf1cbd40286f10fa1da3990b649f
https://doi.org/10.1016/j.bmc.2004.11.005
https://doi.org/10.1016/j.bmc.2004.11.005
Autor:
Koji Nagai, Kazumi Hayashi, Tomihisa Kawasaki, Masatoshi Taniguchi, Toshio Uemura, Jun Takasaki, Tetsu Saito, Yumiko Moritani, Takeshi Shigenaga, Hajime Takamatsu
Publikováno v:
Thrombosis and Haemostasis. 94:184-192
SummaryThe pharmacological properties of YM-254890,a specific Gαq/11 inhibitor, on acute thrombosis and chronic neointima formation after vascular injury have been investigated. FeCl3 was used to induce vascular injury in the carotid artery of mice.
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::83c39514c436c40903395ccc84e5edb4
https://doi.org/10.1160/th04-09-0635
https://doi.org/10.1160/th04-09-0635
Autor:
Tetsu Saito, Yumiko Moritani, Tomihisa Kawasaki, Masato Kobori, Masatoshi Taniguchi, Jun Takasaki, Kazumi Hayashi
Publikováno v:
Journal of Biological Chemistry. 279:47438-47445
YM-254890, which was isolated from the culture broth of Chromobacterium sp., inhibits ADP-induced platelet aggregation and has antithrombotic and thrombolytic effects. YM-254890 blocks Gαq/11-coupled ADP receptor P2Y1-mediated Ca2+ mobilization. Her
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::29173596e065f020b51e755493ecda10
https://doi.org/10.1074/jbc.m408846200
https://doi.org/10.1074/jbc.m408846200
Autor:
Shin-ichi Tsukamoto, Fukushi Hirayama, Yuta Taniuchi, Tomihisa Kawasaki, Tsukasa Ishihara, Yumiko Moritani, Shuichi Sakamoto, Yoshiyuki Iwatsuki, Yuzo Matsumoto, Seiji Kaku, Hiroyuki Koshio, Takeshi Shigenaga, Kazuo Sato, Toshio Uemura, Hiroyuki Kaizawa
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:5415-5426
Factor Xa (fXa) is a serine protease, which plays a pivotal role in the coagulation cascade. To improve the oral anticoagulant activity of fXa inhibitors containing a 1,4-diazepane moiety as the P4 part, a prodrug strategy was examined. Among the com
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::f724f7e55e781c6b90ef76c0dfa5fa47
https://doi.org/10.1016/j.bmc.2004.07.046
https://doi.org/10.1016/j.bmc.2004.07.046
Autor:
Ken-ichi Suzumura, Masatoshi Taniguchi, Mitsuhiro Sekiguchi, Shin-ichi Tsukamoto, Kazumi Hayashi, Tomihisa Kawasaki, Jun Takasaki, Shigeo Fujita, Yumiko Moritani, Tetsu Saito, Kenichi Suzuki, Koji Nagai
Publikováno v:
Bioorganic & Medicinal Chemistry. 12:3125-3133
The structure elucidation and biological activity of novel YM-254890 (1) analogues and semi-synthetic derivatives are described. Three natural analogues, YM-254891 (2), YM-254892 (3), and YM-280193 (4), were isolated from the fermentation broth of Ch
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ce57c408c7d12172c98988cc8ac36f66
https://doi.org/10.1016/j.bmc.2004.04.006
https://doi.org/10.1016/j.bmc.2004.04.006
Autor:
Seiji Kaku, Tomihisa Kawasaki, Yoshiyuki Iwatsuki, Yuji Mano, Fukushi Hirayama, Yuta Taniuchi, Yumiko Moritani, Hiroyuki Koshio, Yuzo Matsumoto
Publikováno v:
Drug Development Research. 58:190-195
The antithrombotic effects of YM466, a synthetic direct inhibitor of human factor Xa (FXa), were evaluated in an arterio-venous shunt thrombosis model in squirrel monkeys. YM466 significantly inhibited thrombus formation after continuous IV zx infusi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f2d84f246dc7a5662fdd2108d87163fa
https://doi.org/10.1002/ddr.10159
https://doi.org/10.1002/ddr.10159
Autor:
Masatoshi Taniguchi, Tomihisa Kawasaki, Koji Nagai, Tetsu Saito, Kenichi Suzuki, Shin-ichi Tsukamoto, Shigeo Fujita, Kazumi Hayashi, Yumiko Moritani, Jun Takasaki, Nakako Arao
Publikováno v:
The Journal of Antibiotics. 56:358-363
A novel platelet aggregation inhibitor, YM-254890, was isolated from the culture broth of strain QS3666. This strain was isolated from a soil sample collected at Okutama, Tokyo, Japan, and was identified as Chromobacterium sp. by morphological and ph
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9163a141ab42d26f0a732ca5c39b6c10
https://doi.org/10.7164/antibiotics.56.358
https://doi.org/10.7164/antibiotics.56.358