Zobrazeno 1 - 10
of 24
pro vyhledávání: '"Yumiko Isobe"'
Autor:
Yang Li, Yunzhong Nie, Xia Yang, Yang Liu, Xiaoshan Deng, Yoshihito Hayashi, Riana Plummer, Qinglin Li, Na Luo, Toshiharu Kasai, Takashi Okumura, Yu Kamishibahara, Takemasa Komoto, Takuya Ohkuma, Satoshi Okamoto, Yumiko Isobe, Kiyoshi Yamaguchi, Yoichi Furukawa, Hideki Taniguchi
Publikováno v:
Cell Reports, Vol 43, Iss 3, Pp 113918- (2024)
Summary: Maximizing the potential of human liver organoids (LOs) for modeling human septic liver requires the integration of innate immune cells, particularly resident macrophage Kupffer cells. In this study, we present a strategy to generate LOs con
Externí odkaz:
https://doaj.org/article/c85fa5cd49224938abb19488da79baeb
Autor:
Kiyoshi Yamaguchi, Saya Nakagawa, Akari Saku, Yumiko Isobe, Rui Yamaguchi, Paul Sheridan, Kiyoko Takane, Tsuneo Ikenoue, Chi Zhu, Masashi Miura, Yuya Okawara, Satoru Nagatoishi, Hiroko Kozuka-Hata, Masaaki Oyama, Susumu Aikou, Yuka Ahiko, Dai Shida, Kouhei Tsumoto, Satoru Miyano, Seiya Imoto, Yoichi Furukawa
Publikováno v:
iScience, Vol 26, Iss 4, Pp 106563- (2023)
Summary: Bromodomain-containing protein 8 (BRD8) is a subunit of the NuA4/TIP60-histone acetyltransferase complex. Although BRD8 has been considered to act as a co-activator of the complex, its biological role remains to be elucidated. Here, we uncov
Externí odkaz:
https://doaj.org/article/40eae7249af94873810670d3565eb286
Autor:
Takeshi Fujino, Susumu Goyama, Yuki Sugiura, Daichi Inoue, Shuhei Asada, Satoshi Yamasaki, Akiko Matsumoto, Kiyoshi Yamaguchi, Yumiko Isobe, Akiho Tsuchiya, Shiori Shikata, Naru Sato, Hironobu Morinaga, Tomofusa Fukuyama, Yosuke Tanaka, Tsuyoshi Fukushima, Reina Takeda, Keita Yamamoto, Hiroaki Honda, Emi K. Nishimura, Yoichi Furukawa, Tatsuhiro Shibata, Omar Abdel-Wahab, Makoto Suematsu, Toshio Kitamura
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
ASXL1 mutations are frequently found in age-related clonal haemaotopoiesis (CH), but how they drive CH is unclear. Here the authors show that expression of C-terminal truncated ASXL1 in haematopoietic stem cells (HSCs) leads to Akt de-ubiquitination,
Externí odkaz:
https://doaj.org/article/5a4339b6caee4c1d9bbb984e54dddbf0
Autor:
Kiyoshi Yamaguchi, Chiaki Horie, Kiyoko Takane, Tsuneo Ikenoue, Saya Nakagawa, Yumiko Isobe, Yasunori Ota, Tetsuo Ushiku, Mariko Tanaka, Jun Fujishiro, Noriko Hoshino, Atsuhiro Arisue, Satoshi Nishizuka, Susumu Aikou, Dai Shida, Yoichi Furukawa
Publikováno v:
Cancer scienceREFERENCES.
The Wnt/β-catenin signaling pathway plays a key role in development and carcinogenesis. Although some target genes of this signaling have been identified in various tissues and neoplasms, the comprehensive understanding of the target genes and their
Autor:
Chiaki, Horie, Chi, Zhu, Kiyoshi, Yamaguchi, Saya, Nakagawa, Yumiko, Isobe, Kiyoko, Takane, Tsuneo, Ikenoue, Yasunori, Ohta, Yukihisa, Tanaka, Susumu, Aikou, Giichiro, Tsurita, Yuka, Ahiko, Dai, Shida, Yoichi, Furukawa
Publikováno v:
Oncol Lett
Aberrant activation of the Wnt/β-catenin signaling pathway plays a crucial role in the development and progression of colorectal cancer. Previously, we identified a set of candidate genes that were regulated by this signaling pathway, and the presen
Autor:
Akiko Matsumoto, Akiho Tsuchiya, Yumiko Isobe, Tatsuhiro Shibata, Shiori Shikata, Makoto Suematsu, Satoshi Yamasaki, Yosuke Tanaka, Reina Takeda, Takeshi Fujino, Kiyoshi Yamaguchi, Naru Sato, Omar Abdel-Wahab, Daichi Inoue, Tomofusa Fukuyama, Yoichi Furukawa, Emi K. Nishimura, Toshio Kitamura, Shuhei Asada, Yuki Sugiura, Hiroaki Honda, Susumu Goyama, Tsuyoshi Fukushima, Hironobu Morinaga, Keita Yamamoto
Publikováno v:
Nature Communications
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Nature Communications, Vol 12, Iss 1, Pp 1-20 (2021)
Somatic mutations of ASXL1 are frequently detected in age-related clonal hematopoiesis (CH). However, how ASXL1 mutations drive CH remains elusive. Using knockin (KI) mice expressing a C-terminally truncated form of ASXL1-mutant (ASXL1-MT), we examin
Autor:
Yumiko, Isobe
Publikováno v:
英米文学. 59(1):233-254
Autor:
Koh Shinoda, Yasuho Taura, Shuji Terai, Yumiko Isobe-Harima, Tomoaki Murata, Kazuhito Itamoto, Izumi Miura, Makoto Segawa, Isao Sakaida
Publikováno v:
Liver International. 28:117-125
Background/Aims: To elucidate the pathogenesis of hepatic encephalopathy (HE), we developed a new HE model with behaviour disorder. Methods: Male Wistar rats were divided into four treatment groups: a HE model: acetaminophen (APAP)+3-methylcholanthre
Autor:
Toshikuni Sasaoka, Heather L. Melrose, Sadahiro Azuma, Etsuro Ohta, Matthew J. Farrer, Mitsue Kurihara, Kazuya Iwabuchi, Ryuichi Nagashima, Makoto Kubo, Tatsunori Maekawa, Yumiko Isobe, Koji Eshima, Fumiya Obata
Publikováno v:
Journal of neuroimmunology. 292
LRRK2 is the causal molecule of autosomal dominant familial Parkinson's disease. B2 cells express a much higher LRRK2 mRNA level than B1 cells. To reveal the function of LRRK2 in B cells, we analyzed B cell functions in LRRK2-knockout (LRRK2(-/-)) mi