Zobrazeno 1 - 10
of 13
pro vyhledávání: '"Yumiko Asakura"'
Autor:
Kenzo Takahashi, Shiro Nakaike, Miyuki Hori, Akihiko Hoshino, Junji Kamon, Nobutomo Tsuruzoe, Yumiko Asakura, Takehisa Iwama, Shuya Takahashi, Masafumi Kawanishi
Publikováno v:
European Journal of Pharmacology. 618:63-69
We evaluated the effects of NT-702 (parogrelil hydrochloride, NM-702, 4-bromo-6-[3-(4-chlorophenyl) propoxy]-5-[(pyridine-3-ylmethyl) amino] pyridazin-3(2H)-one hydrochloride), a selective phosphodiesterase 3 inhibitor, on the asthmatic response in g
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::062e93c5381f4c49f1d812131c37f0df
https://doi.org/10.1016/j.ejphar.2009.07.005
https://doi.org/10.1016/j.ejphar.2009.07.005
Autor:
Takafumi Jinushi, Takashi Nishimura, Akihiko Hoshino, Yoshitaka Tanaka, Kenji Chamoto, Shigeru Ashino, Tsuguhide Takeshima, Takanobu Sakurai, Hiroaki Ikeda, Yumiko Asakura, Yasuo Mita, Akiko Takaoka, Takashi Teramura, Shiro Nakaike, Takemasa Tsuji, Junko Matsuzaki
Publikováno v:
International Immunology. 16:1497-1505
When wild-type BALB/c mice were transferred with OVA-specific Th2 cells followed by OVA inhalation, a severe eosinophilia, mucus hypersecretion and airway hyper-responsiveness (AHR) was induced in parallel with a marked elevation of IL-4, IL-5 and IL
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::dd5d7f283beeac01cf0022ceec1eeb5d
https://doi.org/10.1093/intimm/dxh151
https://doi.org/10.1093/intimm/dxh151
Critical role for OX40 ligand in the development of pathogenic Th2 cells in a murine model of asthma
Autor:
Akiko Takaoka, Hisaya Akiba, Hideo Yagita, Ko Okumura, Naoto Ishii, Yumiko Asakura, Akihiko Hoshino, Shiro Nakaike, Kazuo Sugamura, Takanobu Sakurai, Yoshitaka Tanaka, Yasuo Mita
Publikováno v:
European Journal of Immunology. 33:861-869
Bronchial asthma is characterized by massive infiltration of eosinophils and airway hyperreactivity (AHR), which are caused by overproduction of Th2 cytokines (IL-4, IL-5, and IL-13) by allergen-specific T cells. We recently demonstrated a critical c
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::0bd58ac4f8bdaf9f2d0e6c3148ac1cf0
https://doi.org/10.1002/eji.200323455
https://doi.org/10.1002/eji.200323455
Autor:
Daisuke Wakasugi, Rie Nishikawa-Shimono, Kazuhito Watanabe, Yoshinori Sekiguchi, Madoka Kawamura, Masahumi Kawanishi, Yumiko Asakura, Tetsuo Takayama, Akiko Takaoka
Publikováno v:
Chemicalpharmaceutical bulletin. 62(6)
Synthesis and structure-activity relationship of a novel series of isoquinoline CRTH2 antagonists bearing a methylene linker between the isoquinoline and benzamide moieties were described. Optimization focusing on the substituents of the benzamide po
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bb997ed88d7cbcfdd371e41398e71eac
https://pubmed.ncbi.nlm.nih.gov/24881658
https://pubmed.ncbi.nlm.nih.gov/24881658
Autor:
Yoshitaka Tanaka, Yasuo Mita, Shiro Nakaike, Toshiaki Koda, Yuji Togashi, Takashi Nishimura, Yumiko Asakura, Takafumi Jinushi, Akiko Takaoka, Kazuhito Watanabe, Takemasa Tsuji, Kouji Matsushima, Akihiko Hoshino
Publikováno v:
The Journal of Immunology. 167:2349-2353
Ag-specific Th1 and Th2 cells have been demonstrated to play a critical role in the induction of allergic diseases. Here we have investigated the precise mechanisms of Th1-induced airway inflammation. Airway inflammation was induced in BALB/c mice by
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::da894974b10a3de9d007e429d7f7871c
https://doi.org/10.4049/jimmunol.167.4.2349
https://doi.org/10.4049/jimmunol.167.4.2349
Autor:
Koji Ito, Yumiko Asakura, Akihiko Hoshino, Akio Mori, Keiji Miyazawa, Matsunobu Suko, Takeo Ohmura, Hirokazu Okudaira, Yasushi Okumura, Satoshi Inoue, Osamu Kaminuma, Toyokazu Yokota
Publikováno v:
Blood. 89:2891-2900
Glucocorticoids (GC) have long been used as the most effective agents for the treatment of allergic diseases accompanied by eosinophilia such as chronic asthma and atopic dermatitis. The development of chronic eosinophilic inflammation is dependent o
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ecacec13f54534d102a8ccfe90bc4a25
https://doi.org/10.1182/blood.v89.8.2891
https://doi.org/10.1182/blood.v89.8.2891
Autor:
Kazuo Noguchi, Kanako Takahashi, Yumiko Asakura, Norihisa Ishiwata, Nobutomo Tsuruzoe, Akiko Mitani, Masafumi Kawanishi, Shiro Nakaike, Hiroshi Nishiyama, Kenzo Takahashi, Miyuki Hori, Shuya Takahashi, Yusuke Ito, Norimasa Shudo
Publikováno v:
Life sciences. 81(12)
NT-702 (parogrelil hydrochloride, NM-702), 4-bromo-6-[3-(4-chlorophenyl)propoxy]-5-[(pyridin-3-ylmethyl)amino]pyridazin-3(2H)-one hydrochloride, a novel phosphodiesterase (PDE) inhibitor synthesized as a potent vasodilatory and antiplatelet agent, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::85f5f36f1cf576813e63501dc353d60a
https://pubmed.ncbi.nlm.nih.gov/17850826
https://pubmed.ncbi.nlm.nih.gov/17850826
Autor:
Yoko Nishizaki, Yumiko Asakura, Kazuhiko Yamamoto, Tadashi Mikami, Keiji Miyazawa, Matsunobu Suko, Akihiko Hoshino, Osamu Kaminuma, Toru Ando, Yasushi Okumura, Takeo Ohmura, Akio Mori, Hizokazu Okudaira
Publikováno v:
The Journal of allergy and clinical immunology. 100(6 Pt 2)
Background: Cytokines produced by helper T cells are intimately involved in chronic allergic diseases associated with eosinophilic inflammation. Objective: We investigated the production of IL-5, a potent growth factor and chemotactic factor for eosi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::af0a9dba47ba7b26d15000389ee7de47
https://pubmed.ncbi.nlm.nih.gov/9440546
https://pubmed.ncbi.nlm.nih.gov/9440546
Autor:
Matsunobu Suko, Takeo Ohmura, Tadashi Mikami, Yumiko Asakura, Akihiko Hosino, Akio Mori, Hirokazu Okudaira, Toshifumi Nagahori, Osamu Kaminuma, Yoko Nishizaki
Publikováno v:
Advances in Experimental Medicine and Biology ISBN: 9781461376842
Infiltration of various inflammatory cells into the bronchial mucosa and submucosa is a prominent pathological feature of bronchial asthma.1–3 Persistent mucosal inflammation, particularly epithelial damage caused by eosinophil-derived products, is
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::a927e6665be202b00ad773df56d2fdeb
https://doi.org/10.1007/978-1-4615-5855-2_64
https://doi.org/10.1007/978-1-4615-5855-2_64
Autor:
Yumiko Asakura, Koji Ito, Takeo Ohmura, Matsunobu Suko, Yoko Nishizaki, Akio Mori, S Inoue, Osamu Kaminuma, Tadashi Mikami, Hirokazu Okudaira
Publikováno v:
International archives of allergy and immunology. 107(1-3)
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c23d0ca81913fc26b0acb3139400619b
https://pubmed.ncbi.nlm.nih.gov/7613176
https://pubmed.ncbi.nlm.nih.gov/7613176