Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Yumi Yamashita-Kanemaru"'
Selective DNAM-1 expression on small peritoneal macrophages contributes to CD4+ T cell costimulation
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Abstract Mouse peritoneal macrophages consist of two subsets: large peritoneal macrophages (LPMs) and small peritoneal macrophages (SPMs), defined as CD11bhiF4/80hi and CD11b+F4/80lo cells, respectively. We reveal that SPMs, but not LPMs, have the ab
Externí odkaz:
https://doaj.org/article/8c34dccbeeeb4050956e420ac25b6467
Autor:
Yoko Nagumo, Akiko Iguchi-Manaka, Yumi Yamashita-Kanemaru, Fumie Abe, Günter Bernhardt, Akira Shibuya, Kazuko Shibuya
Publikováno v:
PLoS ONE, Vol 9, Iss 11, p e112415 (2014)
Tumor recognition by immune effector cells is mediated by antigen receptors and a variety of adhesion and costimulatory molecules. The evidence accumulated since the identification of CD155 and CD112 as ligands for DNAM-1 in humans and mice has sugge
Externí odkaz:
https://doaj.org/article/cfda1dca4e3c4101a8c55b98b858da2f
Publikováno v:
Monoclonal Antibodies in Immunodiagnosis and Immunotherapy. 40:52-59
DNAM-1 is an activating immunoreceptor expressed on hematopoietic cells, including both CD4+ and CD8+ T cells, natural killer cells, and platelets. Since DNAM-1 is involved in the pathogenesis of various inflammatory diseases and cancers in humans as
Autor:
Yuho Nakamura-Shinya, Kazuki Sato, Akira Shibuya, André Veillette, Kazuko Shibuya, Motohito Goto, Fumie Abe, Yumi Yamashita-Kanemaru, Masafumi Muratani, Rikito Murata, Mamoru Ito, Kazumasa Kanemaru
Publikováno v:
Proc Natl Acad Sci U S A
Regulatory T (Treg) cells that express forkhead box P3 (Foxp3) are pivotal for immune tolerance. Although inflammatory mediators cause Foxp3 instability and Treg cell dysfunction, their regulatory mechanisms remain incompletely understood. Here, we s
Autor:
Akiko Iguchi-Manaka, Yumi Yamashita-Kanemaru, Rikito Murata, Kazuko Shibuya, Akira Shibuya, Genki Okumura
Publikováno v:
The Journal of Experimental Medicine
This report demonstrated that soluble CD155 interferes with the DNAM-1–mediated antitumor immunity mediated by NK cells and promotes lung colonization of B16/BL6 melanoma cells.
CD155 is a ligand for DNAM-1, TIGIT, and CD96 and is involved in
CD155 is a ligand for DNAM-1, TIGIT, and CD96 and is involved in
Selective DNAM-1 expression on small peritoneal macrophages contributes to CD4+ T cell costimulation
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-8 (2018)
Mouse peritoneal macrophages consist of two subsets: large peritoneal macrophages (LPMs) and small peritoneal macrophages (SPMs), defined as CD11bhiF4/80hi and CD11b+F4/80lo cells, respectively. We reveal that SPMs, but not LPMs, have the ability to
Autor:
Naohiro Katagiri, Norihiko Ohbayashi, Yuji Funakoshi, Yumi Yamashita-Kanemaru, Yuki Miura, Akira Shibuya, Tsunaki Hongu, Van Ngo Thai Bich, Yasunori Kanaho
Publikováno v:
Scientific Reports, Vol 8, Iss 1, Pp 1-13 (2018)
Scientific Reports
Scientific Reports
Two major phospholipase D (PLD) isozymes in mammals, PLD1 and PLD2, hydrolyze the membrane phospholipid phosphatidylcholine to choline and the lipid messenger phosphatidic acid. Although their roles in cancer cells have been well studied, their funct
Autor:
Hideo Yagita, Koichiro Uchida, Ko Okumura, Jiro Kitaura, Yoshie Kametani, Yumi Yamashita-Kanemaru, Naoko Negishi, Takehito Sato, Sonoko Habu, Kazuko Shibuya
Publikováno v:
ImmunoHorizons. 2(10)
The precise mechanism of how the regulatory T cell population elicits and maintains tolerant state in activated T cells is poorly understood. To address this issue, we established an in vitro coculture system using mouse T cells and showed that toler
Autor:
Rei Hirochika, Akira Shibuya, Daisuke Komori, Kazuko Shibuya, Keisuke Naito, Yumi Yamashita-Kanemaru, Yuho Nakamura
Publikováno v:
Monoclonal antibodies in immunodiagnosis and immunotherapy. 37(2)
T cell immunoglobulin and ITIM domains (TIGIT) is an inhibitory immunoreceptor expressed on NK cells, effector and memory T cells, and regulatory T cells (Tregs). The ligands for TIGIT are CD155 (PVR) and CD112 (PVRL2, nectin-2), which are broadly ex
Publikováno v:
Scientific Reports
Mouse peritoneal macrophages consist of two subsets: large peritoneal macrophages (LPMs) and small peritoneal macrophages (SPMs), defined as CD11bhiF4/80hi and CD11b+F4/80lo cells, respectively. We reveal that SPMs, but not LPMs, have the ability to