Zobrazeno 1 - 10
of 20
pro vyhledávání: '"Yumi Sekine"'
Autor:
Taisuke Kato, Yumi Sekine, Hiroaki Nozaki, Masahiro Uemura, Shoichiro Ando, Sachiko Hirokawa, Osamu Onodera
Publikováno v:
Frontiers in Aging Neuroscience, Vol 12 (2020)
It is increasingly becoming apparent that cerebrovascular dysfunction contributes to the pathogenic processes involved in vascular dementia, Alzheimer’s disease, and other neurodegenerative disorders. Under these pathologic conditions, the degenera
Externí odkaz:
https://doaj.org/article/81a2482bf7ef41e5b05a8045428d3ed3
Autor:
Taisuke Kato, Toshiya Sato, Sachiko Hirokawa, Natsumi Fujita, Akihiro Sugai, Yusuke Kawashima, Yasuko Toyoshima, Fuyuki Kametani, Akihide Koyama, Shoji Tsuji, Hironaka Igarashi, Atsushi Sugie, Rie Saito, Masaki Matsumoto, Yuya Hatano, Masaki Fukunaga, Masato Kanazawa, Masato Hasegawa, Osamu Onodera, Hirotoshi Kawata, Ri-Ichiroh Manabe, Shoichiro Ando, Masahiro Uemura, Shigeo Murayama, Satoshi Saito, Masafumi Ihara, Akiyoshi Kakita, Masatoyo Nishizawa, Yumi Sekine, Hiroaki Nozaki
Publikováno v:
J Clin Invest
Cerebral small vessel disease (CSVD) causes dementia and gait disturbance due to arteriopathy. Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a hereditary form of CSVD caused by loss of high-t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2a139e0c1d46a417b3295090b29c9a18
https://doi.org/10.1172/jci140555
https://doi.org/10.1172/jci140555
Autor:
Sachiko Hirokawa, Yumi Sekine, Masahiro Uemura, Shoichiro Ando, Taisuke Kato, Osamu Onodera, Hiroaki Nozaki
Publikováno v:
Frontiers in Aging Neuroscience
Frontiers in Aging Neuroscience, Vol 12 (2020)
Frontiers in Aging Neuroscience, Vol 12 (2020)
It is increasingly becoming apparent that cerebrovascular dysfunction contributes to the pathogenic processes involved in vascular dementia, Alzheimer’s disease, and other neurodegenerative disorders. Under these pathologic conditions, the degenera
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::9f25d5e5cc62a7dca7de8f8a988b2893
https://doi.org/10.3389/fnagi.2020.00151
https://doi.org/10.3389/fnagi.2020.00151
Autor:
Shigeko Yashiro, Tomohiro Iida, Natsuyo Yoshida-Hata, Yuuka Yamamoto, Shinichi Oka, Takeshi Nishijima, Yumi Sekine
Publikováno v:
Japanese Journal of Ophthalmology. 62:373-389
To assess the usefulness of spectral domain optical coherence tomography (SD-OCT) and fundus autofluorescence (FAF) findings in cytomegalovirus (CMV) retinitis. Observational case series. Thirteen eyes of 11 human immunodeficiency virus (HIV)-positiv
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a48351152368f202c2b04d075680bcf3
https://doi.org/10.1007/s10384-018-0574-9
https://doi.org/10.1007/s10384-018-0574-9
Autor:
Hiroaki Nozaki, Ryoko Koike, Toshiki Mizuno, Akihide Koyama, Ayuka Murakami, Akio Yokoseki, Masahiro Makino, Ikuko Mizuta, Yohei Saito, Suzuko Moritani, Muichi Kaito, Osamu Onodera, Atsushi Shiga, Yumi Sekine, Kazuhide Miyazaki, Kenju Hara, Takeshi Momotsu, Tomoko Noda, Taisuke Kato, Shoichi Ito, Megumi Nihonmatsu, Masatoyo Nishizawa, Naoto Endo, Ryozo Kuwano, Mari Yoshida, Masahiro Uemura
Publikováno v:
Neurology. 86:1964-1974
Objective: To elucidate the molecular mechanism of mutant HTRA1-dependent cerebral small vessel disease in heterozygous individuals. Methods: We recruited 113 unrelated index patients with clinically diagnosed cerebral small vessel disease. The codin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ae77e394fdff4fdcb644052f72b4a9c0
https://doi.org/10.1212/wnl.0000000000002694
https://doi.org/10.1212/wnl.0000000000002694
Autor:
Yutaka Shimoe, Akiko Shirata, Sohei Yanagawa, Yumi Sekine, Masatoyo Nishizawa, Hiroaki Nozaki, Osamu Onodera, Mikio Hirayama, Yoshinori Nishimoto, Masato Tamura, Toshio Fukutake
Publikováno v:
Neurology. 85:459-463
Objectives: The objective of this study was to clarify the characteristic brain MRI findings for genetically diagnosed CARASIL (cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy). Methods: Seven patients with
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bd21615e50af91cc1925ce9f173a0886
https://doi.org/10.1212/wnl.0000000000001803
https://doi.org/10.1212/wnl.0000000000001803
Autor:
Suzuko Moritani, Akihide Koyama, Atsushi Shiga, Osamu Onodera, Toshiki Mizuno, Mari Yoshida, Tomoko Noda, Kenju Hara, Muichi Kaito, Yumi Sekine, Takeshi Momotsu, Masatoyo Nishizawa, Masahiro Makino, Hiroaki Nozaki, Taisuke Kato, Ryozo Kuwano, Shoichi Ito, Kazuhide Miyazaki, Ikuko Mizuta, Ryoko Koike, Masahiro Uemura, Yohei Saito, Naoto Endo, Ayuka Murakami, Akio Yokoseki, Megumi Nihonmatsu
Publikováno v:
Stroke. 48
Introduction: Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL), an autosomal recessive inherited cerebral small vessel disease (CSVD), involves severe leukoaraiosis, multiple lacunar infarcts, earl
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::33d726d96daae8feb00419af77e13bd5
https://doi.org/10.1161/str.48.suppl_1.tp269
https://doi.org/10.1161/str.48.suppl_1.tp269
Autor:
Sohei Yanagawa, Osamu Onodera, Kazuhide Miyazaki, Kiyomi Yamane, Mikio Hirayama, Yumi Sekine, Masahiro Uemura, Ikuko Mizuta, Yoshinori Nishimoto, Masatoyo Nishizawa, Masato Tamura, Yutaka Shimoe, Muichi Kaito, Akiko Shirata, Tomoko Noda, Hiroaki Nozaki, Toshiki Mizuno
Publikováno v:
Stroke. 48
Introduction: Cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL) is a cerebral small-vessel disease (CSVD). Mutations in the high-temperature requirement serine peptidase A1 gene ( HTRA1 ) cause CARA
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dc621590c03addc5ead5e375c2591224
https://doi.org/10.1161/str.48.suppl_1.tmp92
https://doi.org/10.1161/str.48.suppl_1.tmp92
Autor:
Masatoyo Nishizawa, Takeshi Ikeuchi, Toshiyuki Tezuka, Yumi Sekine, Kensaku Kasuga, Takayoshi Tokutake, Ryuji Yajima
Publikováno v:
Journal of Biological Chemistry. 287:35222-35233
Alzheimer disease (AD) is neuropathologically characterized by the formation of senile plaques from amyloid-β (Aβ) and neurofibrillary tangles composed of phosphorylated Tau. Although there is growing evidence for the pathogenic role of soluble Aβ
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2353282d35080780f646a61654f345d5
https://doi.org/10.1074/jbc.m112.348300
https://doi.org/10.1074/jbc.m112.348300
Autor:
Yutaka Tamada, Takashi Nakanoma, Hiroshi Ishikawa, Koki Tai, Naoki Ishihara, Yasuko Yorinaga, Yumi Sekine, Masahiro Yoshioka, Shouji Kutsuki, Hiromasa Tsuda
Publikováno v:
Internal Medicine. 48:1457-1460
A 74-year-old woman presented with abducens nerve palsy, postganglionic Horner syndrome and sensory disturbance in the territory of the ophthalmic nerve on the left side. Cranial magnetic resonance imaging demonstrated a gadolinium-enhanced lesion wi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::2251b96995b084cfaeba050d6d0d9949
https://doi.org/10.2169/internalmedicine.48.2319
https://doi.org/10.2169/internalmedicine.48.2319