Zobrazeno 1 - 10
of 15
pro vyhledávání: '"Yumi N. Imai"'
Autor:
Masashi Yamasaki, Ayumu Sato, Tsuneo Oda, Gyorgy Snell, Junya Shirai, Yoshiyuki Fukase, Bi-Ching Sang, Keiko Uga, Atsuko Ochida, Yusuke Sasaki, Hideyuki Nakagawa, Akira Shibata, Satoshi Yamamoto, Naoki Ishii, Yoshihide Tomata, Shoji Fukumoto, Mikio Shirasaki, Isaac Hoffman, Mitsunori Kono, Robert J. Skene, Yumi N. Imai
Publikováno v:
ChemMedChem. 14(22)
Retinoic-acid-related orphan receptor γt (RORγt) inverse agonists could be used for the treatment of autoimmune diseases. Previously, we reported a novel quinazolinedione 1 a with a flexible linear linker as a novel RORγt inverse agonist. A U-shap
Publikováno v:
QSAR & Combinatorial Science. 28:869-873
A geometry analysis of Cl–π interactions in protein–ligand complex crystal structures, showed two distinct geometries: “edge-on” approach of a Cl atom to a ring atom or CC bond and “face-on” approach towards the ring centroid, with an av
Publikováno v:
Journal of Medicinal Chemistry. 52:1630-1638
To characterize drug binding to the human ether-a-go-go related gene (hERG) channel, a synergic approach interplaying patch-clamp experiments and a docking study was developed. Mutations were introduced into concatenated dimers of the hERG channel th
Publikováno v:
Journal of Medicinal Chemistry. 50:1189-1196
The nonbonded contacts analysis of 14 polar and aromatic amino acid side chains was carried out for protein-ligand complexes derived from the crystal structures in the Protein Data Bank. Through the exhaustive analysis, several unusual contacts were
Autor:
Takahito Hara, Mitsuru Shiraishi, Junichi Miyazaki, Akihiro Tasaka, Masuo Yamaoka, Takenori Hitaka, Toshio Miyawaki, Katsuji Aikawa, Naoyuki Kanzaki, Masami Kusaka, Satoshi Yamamoto, Yumi N. Imai
Publikováno v:
Bioorganicmedicinal chemistry. 23(10)
To develop effective drugs for hypogonadism, sarcopenia, and cachexia, we designed, synthesized, and evaluated selective androgen receptor modulators (SARMs) that exhibit not only anabolic effects on organs such as muscles and the central nervous sys
Autor:
Tomohiro Okawa, Shiro Takekawa, Kazuaki Takami, Koki Kato, Yumi N. Imai, Sunghi Ryu, Makoto Kamata, Jun Kunitomo, Masaharu Nakayama, Shinichi Masada, Nobuhiro Suzuki, Yoshihide Nakano, Toshiki Murata, Masahiro Kamaura, Yuji Ishihara, Kaoru Watanabe, Hitomi Ogino, Shizuo Kasai, Yasutaka Nagisa, Tomoko Kaisho, Shuntarou Ashina
Publikováno v:
Journal of medicinal chemistry. 55(9)
Recently, we discovered 3-aminomethylquinoline derivative 1, a selective, highly potent, centrally acting, and orally bioavailable human MCH receptor 1 (hMCHR1) antagonist, that inhibited food intake in F344 rats with diet-induced obesity (DIO). Subs
Publikováno v:
Journal of computational chemistry. 30(14)
High-level ab initio calculations have been carried out using a formamide-benzene model system to evaluate amide-pi interactions. The interaction energies were estimated as a sum of the CCSD(T) correlation contribution and the HF energy at the comple
Autor:
Shigenori Ohkawa, Yasuyoshi Arikawa, Tatsumi Matsumoto, Keiko Uga, Seiji Miwatashi, Naoyuki Kanzaki, Yumi N. Imai
Publikováno v:
ChemInform. 40
To investigate the potency of an adenosine A3 receptor (A3AR) antagonist as an anti-asthmatic drug, a novel series of 4-phenyl-5-pyridyl-1,3-thiazole derivatives was synthesized and evaluated in human adenosine A1, A2A and A3 receptor and rat adenosi
Autor:
Tatsumi Matsumoto, Yasuyoshi Arikawa, Seiji Miwatashi, Keiko Uga, Naoyuki Kanzaki, Shigenori Ohkawa, Yumi N. Imai
Publikováno v:
Chemicalpharmaceutical bulletin. 56(8)
To investigate the potency of an adenosine A3 receptor (A3AR) antagonist as an anti-asthmatic drug, a novel series of 4-phenyl-5-pyridyl-1,3-thiazole derivatives was synthesized and evaluated in human adenosine A1, A2A and A3 receptor and rat adenosi
Publikováno v:
Protein science : a publication of the Protein Society. 17(7)
During systematic analysis of nonbonded contacts in protein-ligand complexes derived from crystal structures in the Protein Data Bank, Cl-pi interactions have been found, not only in the well-documented serine proteases but also, to a lesser extent,