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Akademický článek

Effects of Rikkunshi-To, a Japanese kampo medicine, on donepezil-induced gastrointestinal side effects in mice

Autor: Kouichi Yamamoto, Yuhki Sato, Keisuke Hagihara, Kyosuke Kirikihira, Akito Jotaki, Ayana Michihara, Yumi Miyake

Publikováno v: Journal of Pharmacological Sciences, Vol 150, Iss 2, Pp 123-133 (2022)

Donepezil, an acetylcholinesterase inhibitor, is associated with gastrointestinal symptoms, such as nausea, vomiting, and anorexia, which may affect adherence to continuous therapy. Since Rikkunshi-To, a Japanese herbal medicine, activates the ghreli

Externí odkaz: https://doaj.org/article/12f36741bd90403ebfcc34e87e65b559

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Akademický článek

Boron Delivery to Brain Cells via Cerebrospinal Fluid (CSF) Circulation in BNCT of Brain-Tumor-Model Rats—Ex Vivo Imaging of BPA Using MALDI Mass Spectrometry Imaging

Autor: Sachie Kusaka, Yumi Miyake, Yugo Tokumaru, Yuri Morizane, Shingo Tamaki, Yoko Akiyama, Fuminobu Sato, Isao Murata

Publikováno v: Life, Vol 12, Iss 11, p 1786 (2022)

The blood–brain barrier (BBB) is likely to be intact during the early stages of brain metastatic melanoma development, and thereby inhibits sufficient drug delivery into the metastatic lesions. Our laboratory has been developing a system for boron

Externí odkaz: https://doaj.org/article/603a79de3c1e46b3977355089d1f59a1

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Novel mechanisms for the removal of strong replication-blocking HMCES- and thiazolidine-DNA adducts in humans

Autor: Yohei Sugimoto, Yuji Masuda, Shigenori Iwai, Yumi Miyake, Rie Kanao, Chikahide Masutani

Publikováno v: Nucleic Acids Research.

Apurinic/apyrimidinic (AP) sites are DNA lesions created under normal growth conditions that result in cytotoxicity, replication-blocks, and mutations. AP sites are susceptible to β-elimination and are liable to be converted to DNA strand breaks. HM

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::2b029b6075ab988e10042eb89c406bf0
https://doi.org/10.1093/nar/gkad246

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Microscale supercritical fluid extraction combined with supercritical fluid chromatography and proton-transfer-reaction ionization time-of-flight mass spectrometry for a magnitude lower limit of quantitation of lipophilic compounds

Autor: Toshinobu Hondo, Chihiro Ota, Yumi Miyake, Hiroshi Furutani, Michisato Toyoda

Publikováno v: Journal of chromatography. A. 1682

The application of proton transfer ionization reaction mass spectrometry (PTR MS) combined with microscale supercritical fluid extraction (SFE) and supercritical fluid chromatography (SFC) aiming to quantitate single-cell fatty acid analysis levels w

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::fac16a974672b9212b06955248e692ed
https://pubmed.ncbi.nlm.nih.gov/36126560

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Analysis of Nonvolatile Molecules in Supercritical Carbon Dioxide Using Proton-Transfer-Reaction Ionization Time-of-Flight Mass Spectrometry

Autor: Hiroshi Furutani, Chihiro Ota, Michisato Toyoda, Toshinobu Hondo, Yumi Miyake

Publikováno v: Analytical Chemistry. 93:6589-6593

Proton-transfer-reaction (PTR) mass spectrometry (MS) is capable of detecting trace-level volatile organic compounds (VOCs) in gaseous samples in real time. Therefore, PTR-MS has become a popular method in many different study areas. Most of the curr

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3f6f624b8919cdd10b6e52d975343622
https://doi.org/10.1021/acs.analchem.1c00898

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Prenatal ultrasonographic findings and fetal/neonatal outcomes of body stalk anomaly

Autor: Yumi Miyake, Megumi Sasaki, Hiroshi Ishikawa, Ami Nagashima, Chika Akamatsu, Masafumi Yamamoto, Hiromi Nagase, Makiko Ohyama

Publikováno v: Congenital Anomalies. 61:118-126

We studied 27 cases that were post or prenatally diagnosed with body stalk anomaly (BSA) using medical records of prenatal ultrasound findings, pregnancy outcomes, and fetal/neonatal prognosis during 1992 to 2018. Termination of pregnancy was chosen

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b11f94f4f3175556aa9f151d2af6d759
https://doi.org/10.1111/cga.12412

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