Zobrazeno 1 - 8
of 8
pro vyhledávání: '"Yumi Masui"'
Autor:
Hirofumi Noguchi M.D., Ph.D., Shinichi Matsumoto, Teru Okitsu, Yasuhiro Iwanaga, Yukihide Yonekawa, Hideo Nagata, Masayuki Matsushita, Fan-Yan Wei, Hideki Matsui, Kohtaro Minami, Susumu Seino, Yumi Masui, Shiroh Futaki, Koichi Tanaka
Publikováno v:
Cell Transplantation, Vol 14 (2005)
PDX-1 plays a central role in regulating insulin gene transcription and differentiation of insulin-producing cells. It was previously reported that, due to its own Antennapedia-like protein transduction domain (PTD), exogenous PDX-1 protein can perme
Externí odkaz:
https://doaj.org/article/cc4f430465804d7eb976b84171985dec
Autor:
Koji Chono, Takehiro Himaki, Hiroshi Suzuki, Tomoko Okuda, Kimiyasu Shiraki, Yumi Masui, Masaya Takemoto, Bo Haixia, Tohru Daikoku
Publikováno v:
Antiviral Research. 93:301-304
ASP2151 was developed as a novel inhibitor of herpes simplex virus (HSV) and varicella-zoster virus helicase–primase. The anti-HSV activity of ASP2151 toward a clinical HSV isolate with acyclovir (ACV)-resistant/thymidine kinase (TK)-deficiency was
Autor:
Yudai Furuta, Tsutomu Nakagawa, Yukihiro Nishio, Mutsuko Sakai, Jiro Deguchi, Misato Otani, Takahiko Hashizuka, Eiji Sugaru, Hiroyuki Nakahira, Yumi Masui, Hidenori Kimura, Naoyuki Sawada, Michiko Ono, Yayoi Honda, Masakuni Horiguchi
Publikováno v:
Bioorganic & Medicinal Chemistry. 19:5490-5499
We report on the identification of 2-({6-[(3R)-3-amino-3-methylpiperidine-1-yl]-1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydro-5H-pyrrolo[3,2-d]pyrimidine-5-yl}methyl)-4-fluorobenzonitrile (DSR-12727) (7a) as a potent and orally active DPP-4 inhibitor wit
Autor:
Hiroyuki Nakahira, Yukihiro Nishio, Mutsuko Sakai, Michiko Ono, Shinya Tosaki, Eiji Sugaru, Masakuni Horiguchi, Hidenori Kimura, Tsutomu Nakagawa, Yumi Masui
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 20:7246-7249
Structures containing the (R)-3-amino-3-methyl piperidine unit as a new pharmacophore moiety have been shown to possess moderate inhibitory activity for DPP-4 with good pharmacokinetics profile. One of these compounds was found to have good oral bioa
Autor:
Yasuhiro Sato, Masakuni Horiguchi, M. Otani, Mutsuo Taiji, Yumi Masui, Mutsuko Sakai, Hitoshi Hochigai, K. Takubo, Hidenori Kimura, Tsutomu Nakagawa, Atsushi Tsuchida, Hiroyuki Nakahira, Michiko Ono-Kishino, Eiji Sugaru, Yudai Furuta
Publikováno v:
Diabetes, Obesity and Metabolism. 12:421-430
Aims The purpose of this study is to assess the in vitro enzyme inhibition profile of DSP-7238, a novel non-cyanopyrrolidine dipeptidyl peptidase (DPP) IV inhibitor and to evaluate the acute and chronic effects of this compound on glucose metabolism
Autor:
Teru Okitsu, Hideo Nagata, Shinichi Matsumoto, Yusuke Nakai, M. Ueda, Kohtaro Minami, Yukihide Yonekawa, Koichi Tanaka, Yasuhiro Iwanaga, Shiroh Futaki, Yumi Masui, Hirofumi Noguchi, Miho Kawaguchi
Publikováno v:
American Journal of Transplantation. 5:1848-1855
Although application of the Edmonton protocol has markedly improved outcomes for pancreatic islet transplantation, the insulin independence rate after islet transplantation from one donor pancreas has proven to remain low. During the isolation proces
Autor:
Yudai Furuta, Hidenori Kimura, Hitoshi Hochigai, Tomonori Kobayashi, Kazuhiko Okazaki, Noriko Nunami, Yohei Ikuma, Hiroyuki Nakahira, Katsuya Uchiyama, Masakuni Horiguchi, Yasuhiro Sato, Yumi Masui, Mutsuko Sakai
Publikováno v:
Bioorganicmedicinal chemistry. 20(19)
In recent years, dipeptidyl peptidase IV inhibitors have been noted as valuable agents for treatment of type 2 diabetes. Herein, we report the discovery of a novel potent DPP-4 inhibitor with 3H-imidazo[4,5-c]quinolin-4(5H)-one as skeleton. After eff
Autor:
Shiroh Futaki, Kentaro Kogure, Ikuhiko Nakase, Takashi Nakamura, Yumi Masui, Yukio Sugiura, Hideyoshi Harashima
Publikováno v:
The journal of gene medicine. 7(11)
Background One of the critical steps in intracellular gene delivery using cationic liposomes is the endosomal escape of the plasmid/liposome complexes to the cytosol. The addition of GALA, a pH-sensitive fusogenic peptide, is a promising method to ac