Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Yumi Kawase"'
Autor:
Urara Tomita, Yoko Ishimoto, Masaki Ri, Yumi Kawase, Yoshiyuki Hizukuri, Chikako Maru, Kayoko Nanai, Ryuichi Nakamura, Makiko Nakayama, Keiko Oguchi-Oshima, Hiroyuki Sumi, Toshiaki Ohtsuka, Shinsuke Iida, Toshinori Agatsuma
Publikováno v:
Scientific Reports, Vol 14, Iss 1, Pp 1-13 (2024)
Abstract G-protein-coupled receptor class 5 member D (GPRC5D) is detected in malignant plasma cells in approximately 90% of patients diagnosed with multiple myeloma (MM). Here, we constructed BsAb5003, a novel humanized bispecific monoclonal antibody
Externí odkaz:
https://doaj.org/article/775321cb218b48ce8d5246395739263b
Autor:
Tomoko Ishida, Masayuki Shima, Nobuyuki Yamagishi, Yoshitaka Yano, Keiji Wakabayashi, Yuki Yamamura, Nobuyuki Sera, Yumi Kawase, Masaaki Hirakawa, Takao Gotou, Tetsushi Watanabe, Yukiko Uejima, Mohammad Shahriar Khan, Honami Kodama, Takahiro Matsumoto
Publikováno v:
Biological and Pharmaceutical Bulletin. 43:1361-1366
We examined the association of biological components in airborne particles, i.e., proteins and endotoxins, in outdoor air with asthma exacerbation in the Fukuoka metropolitan area, Fukuoka, Japan. Data on emergency department (ED) visits for asthma i
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::673cc2f2a2ed48315c1341abb1fe1a99
https://doi.org/10.1248/bpb.b20-00297
https://doi.org/10.1248/bpb.b20-00297
Autor:
Ryo Ishino, Naoshi Sugimoto, Akihito Matsuoka, Teruhisa Taoka, Maki Oku, Kimihiro Kawakami, Shumpei Uchida, Akifumi Takaori-Kondo, Toshio Kitawaki, Osamu Imataki, Tomoki Todo, Toin H. van Kuppevelt, Norimitsu Kadowaki, Yumi Kawase
Publikováno v:
Molecular Therapy, 29, 762-774
Molecular Therapy, 29, 2, pp. 762-774
Mol Ther
Molecular Therapy, 29, 2, pp. 762-774
Mol Ther
Oncolytic herpes simplex virus type 1 (HSV-1) has been investigated to expand its application to various malignancies. Because hematopoietic cells are resistant to HSV-1, its application to hematological malignancies has been rare. Here, we show that
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ffdd29fcf5c712c6b19e3c5f29870966
http://hdl.handle.net/2066/232072
http://hdl.handle.net/2066/232072
Autor:
Yumi Kawase, Kazuyo Yamamoto, Toshio Kitawaki, Haruyuki Fujita, Norimitsu Kadowaki, Akifumi Takaori-Kondo, Naoshi Sugimoto
Publikováno v:
Immunology letters. 211
Although immunomodulatory drugs (IMiDs) were originally developed as anti-inflammatory drugs, they are effective for multiple myeloma. In order to gain further insights into the immunomodulatory mechanisms of IMiDs for the treatment of inflammatory d
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::972bb3ad65b13e726f26739f9043e680
https://pubmed.ncbi.nlm.nih.gov/31141702
https://pubmed.ncbi.nlm.nih.gov/31141702
Autor:
Tetsuji Noguchi, Yuki Domon, Koichi Yabe, Teppei Fujimoto, Rieko Takano, Yumi Kawase, Kazufumi Kubota, Umezaki Yuma, Miki Yokoyama, Kousei Shimada, Kenjiro Ueda
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 36:127790
We identified (5R)-6-methyl-5-phenyl-1,3,4,5,6,7-hexahydro-2,5-methano-2,6-benzodiazonine (DS21980956: 4-(R)) as a novel [5.2.1]bicyclic basic compound. The scaffold was inspired by fentanyl or pethidine, which possess potent analgesic activities. DS
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134edc323b8d63075394ef43fac0a4d1
https://doi.org/10.1016/j.bmcl.2021.127790
https://doi.org/10.1016/j.bmcl.2021.127790
Autor:
Yusuke Nakaoji, Yuya Deguchi, Nobuyuki Yamagishi, Tomohiro Hasei, Mohammad Shahriar Khan, Yuuki Kubo, Tetsushi Watanabe, Yumi Kawase, Naoko Honda, Hiroaki Nagaoka, Nami Furukawa, Maho Abe, Keiji Wakabayashi, Masanari Watanabe, Takahiro Matsumoto, Souleymane Coulibaly
Publikováno v:
Biologicalpharmaceutical bulletin. 41(1)
To determine the levels of endotoxin, which is a major component of outer membrane of Gram-negative bacteria, and protein in the atmosphere in Sasebo, Japan, we measured these biological materials in fine (aerodynamic diameter ≤2.5 µm) and coarse
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::6db1af8dbd03cd01fde8a9858b8aa90b
https://pubmed.ncbi.nlm.nih.gov/29311473
https://pubmed.ncbi.nlm.nih.gov/29311473
Autor:
Ikeda Takuya, Toshiyasu Takemoto, Yukiko Sekiguchi, Takashi Kagari, Takaichi Shimozato, Takeshi Fukuda, Taiji Goto, Yumi Kawase, Tsuyoshi Nakamura, Takashi Tsuji, Futoshi Nara, Keisuke Suzuki, Takashi Izumi, Takahide Nishi, Masakazu Tamura, Tomohiro Honda, Shin-ichi Inaba, Takako Kimura, Yumiko Mizuno, Chizuko Yahara
Publikováno v:
Bioorganic & Medicinal Chemistry. 22:4246-4256
We report herein the synthesis and structure-activity relationships (SAR) of a series of benzyl ether compounds as an S1P₁ receptor modulator. From our SAR studies, the installation of substituents onto the central benzene ring of 2a was revealed t
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::f6618541f0da9c0a0ca160ca5545ee91
https://doi.org/10.1016/j.bmc.2014.05.035
https://doi.org/10.1016/j.bmc.2014.05.035
Autor:
Naoshi Sugimoto, Teruhisa Taoka, Maki Oku, Toshio Kitawaki, Akifumi Takaori-Kondo, Osamu Imataki, Kimihiro Kawakami, Shumpei Uchida, Ryo Ishino, Akihito Matsuoka, Norimitsu Kadowaki, Tomoki Todo, Yumi Kawase
Publikováno v:
Blood. 134:3242-3242
Background: Oncolytic virus (OV) is an attractive and rapidly developing antitumor therapy. OVs preferentially replicate in tumor cells and exhibit a tumoricidal activity without damaging normal cells. G47Δ is a herpes simplex virus (HSV)-1 genetica
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::b93d2f8114b38dc73281cf6147092d2f
https://doi.org/10.1182/blood-2019-127754
https://doi.org/10.1182/blood-2019-127754
Autor:
Ryotaku Inoue, Reina Kaneko, Tsuyoshi Nakamura, Hiroshi Yuita, Tetsufumi Koga, Eiko Namba, Hatsumi Nasu, Takahide Nishi, Takashi Kagari, Yukiko Sekiguchi, Yumi Kawase, Kazuhiko Tamaki, Shintaro Nakayama, Keiko Oguchi-Oshima, Takaichi Shimozato, Noriko Masubuchi, Yumiko Mizuno, Masayoshi Asano, Takahiro Yamaguchi, Wataru Tomisato, Futoshi Nara, Hiromi Doi-Komuro
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:3083-3088
We have previously disclosed 1,2,4-oxadiazole derivative 3 as a potent S1P3-sparing S1P1 agonist. Although compound 3 exhibits potent and manageable immunosuppressive efficacy in various in vivo models, recent studies have revealed that its 1,2,4-oxa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::dee7d6079550f2c98197e1e96700deda
https://doi.org/10.1016/j.bmcl.2012.03.067
https://doi.org/10.1016/j.bmcl.2012.03.067
Autor:
Hiroshi Yuita, Reina Kaneko, Masayoshi Asano, Takashi Kagari, Takaichi Shimozato, Nobuaki Watanabe, Takahide Nishi, Hiromi Doi, Wataru Tomisato, Takako Kimura, Yumiko Mizuno, Yumi Kawase, Yasuyuki Abe, Miyuki Nagasaki, Yukiko Sekiguchi, Futoshi Nara, Keiko Oguchi-Oshima, Ryotaku Inoue, Tsuyoshi Nakamura, Kazuhiko Tamaki
Publikováno v:
Bioorganic & Medicinal Chemistry Letters. 22:1788-1792
S1P(3)-sparing S1P(1) agonists have attracted attention as a suppressant of autoimmunity with reduced side effects. Our synthetic efforts and extensive SAR studies led to the discovery of 10b named CS-2100 with the EC(50) value of 4.0 nM for human S1
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::bc5d0df16308dff29d13f28a42fb0bce
https://doi.org/10.1016/j.bmcl.2011.12.019
https://doi.org/10.1016/j.bmcl.2011.12.019