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Discovery of potent Mcl-1/Bcl-xL dual inhibitors by using a hybridization strategy based on structural analysis of target proteins

Autor: Yasuhiro Imaeda, Yuta Tanaka, Tomohiro Kawamoto, Ikuo Miyahisa, Katsuji Aikawa, Michiko Tawada, Nobuo Cho, Tomoyasu Ishikawa, Satoshi Sogabe, Tomoya Sameshima, Yumi Imai, Yumi Hayano, Goushi Nishida, Masakazu Inazuka, Misaki Homma, Shigeru Igaki

Publikováno v: Journal of medicinal chemistry. 56(23)

Mcl-1 and Bcl-xL are crucial regulators of apoptosis, therefore dual inhibitors of both proteins could serve as promising new anticancer drugs. To design Mcl-1/Bcl-xL dual inhibitors, we performed structure-guided analyses of the corresponding select

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::371e05ea4b94af36e0b541c5a6c0decd
https://pubmed.ncbi.nlm.nih.gov/24215352

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