Zobrazeno 1 - 10
of 247
pro vyhledávání: '"Yuma Yamada"'
Autor:
Rina Naganawa, Hanjun Zhao, Yuta Takano, Masatoshi Maeki, Manabu Tokeshi, Hideyoshi Harashima, Yuma Yamada
Publikováno v:
International Journal of Molecular Sciences, Vol 25, Iss 8, p 4294 (2024)
Photodynamic therapy is expected to be a less invasive treatment, and strategies for targeting mitochondria, the main sources of singlet oxygen, are attracting attention to increase the efficacy of photodynamic therapy and reduce its side effects. To
Externí odkaz:
https://doaj.org/article/3fc601b32cb444a2b4cbe33d533a88c7
Publikováno v:
Drug Week; 9/1/2023, p1607-1607, 1p
A system that delivers an antioxidant to mitochondria for the treatment of drug-induced liver injury
Autor:
Mitsue Hibino, Masatoshi Maeki, Manabu Tokeshi, Yoichi Ishitsuka, Hideyoshi Harashima, Yuma Yamada
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-13 (2023)
Abstract Mitochondria, a major source of reactive oxygen species (ROS), are intimately involved in the response to oxidative stress in the body. The production of excessive ROS affects the balance between oxidative responses and antioxidant defense m
Externí odkaz:
https://doaj.org/article/6a4aa775ca5e482db74cf645bc046433
Autor:
Atsushi Yamaguchi, Yuto Mukai, Tomoya Sakuma, Katsuya Narumi, Ayako Furugen, Yuma Yamada, Masaki Kobayashi
Publikováno v:
Scientific Reports, Vol 13, Iss 1, Pp 1-8 (2023)
Abstract Metabolic reprogramming of cancer cells is a potential target for cancer therapy. It is also known that a hypoxic environment, one of the tumor microenvironments, can alter the energy metabolism from oxidative phosphorylation to glycolysis.
Externí odkaz:
https://doaj.org/article/410429d2324843fb8209e5d31e411795
Publikováno v:
Pharmaceutics, Vol 16, Iss 1, p 49 (2023)
Most of the energy in neurons is produced in mitochondria. Mitochondria generate the ATP that is essential for neuronal growth, function, and regeneration. Mitochondrial axonal transport plays a crucial role in maintaining neuronal homeostasis and bi
Externí odkaz:
https://doaj.org/article/4bf2dd18a6954d9e93c45d8d666d4796
Publikováno v:
Scientific Reports, Vol 12, Iss 1, Pp 1-13 (2022)
Abstract Given the potential for myocardial stem cell transplantation as a promising treatment for heart failure, numerous clinical trials have been conducted and its usefulness has been clearly confirmed. However, the low rate of engraftment of tran
Externí odkaz:
https://doaj.org/article/71ff6b6d1b1249dfa557cd62cd7ea364
Publikováno v:
Clinical and Translational Discovery, Vol 2, Iss 2, Pp n/a-n/a (2022)
Abstract Ischemic brain disease, a type of cerebrovascular disease, has a high mortality rate, and even when patients survive, they are frequently affected by neurological dysfunction due to damage to brain cells. Strategies to increase intracellular
Externí odkaz:
https://doaj.org/article/61819f7d625f4139bb2c882322629c9f
Autor:
Yuma Yamada, Shinnosuke Daikuhara, Atsushi Tamura, Kei Nishida, Nobuhiko Yui, Hideyoshi Harashima
Publikováno v:
Biomolecules, Vol 13, Iss 6, p 903 (2023)
Activation of autophagy represents a potential therapeutic strategy for the treatment of diseases that are caused by the accumulation of defective proteins and the formation of abnormal organelles. Methylated β-cyclodextrins-threaded polyrotaxane (M
Externí odkaz:
https://doaj.org/article/c83d9795d45b4ad0846c9d6569a756bf
Autor:
Minori Goto, Yuma Yamada, Atsushi Shimura, Tsuyoshi Suzuki, Naomichi Degawa, Takekazu Yamane, Susumu Aoki, Junichiro Urabe, Shinji Hara, Hikaru Nomura, Yoshishige Suzuki
Publikováno v:
Nature Communications, Vol 12, Iss 1, Pp 1-7 (2021)
Goto et al present a bolometer based around the heat generation in magnetic tunnel junctions under auto-oscillation conditions. Unlike superconducting bolometers, the presented device operates at room temperature and sub-GHz frequencies, opening poss
Externí odkaz:
https://doaj.org/article/af36d1832905483fbfc913f8f5343f6c
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 2, p 903 (2023)
Delivering drugs to mitochondria, the main source of energy in neurons, can be a useful therapeutic strategy for the treatment of neurodegenerative diseases. Berberine (BBR), an isoquinoline alkaloid, acts on mitochondria and is involved in mechanism
Externí odkaz:
https://doaj.org/article/8e49dd4b1bba4f769d75897f7f596be8