Zobrazeno 1 - 10
of 21
pro vyhledávání: '"Yuma Tega"'
Autor:
Yuma Tega, Yoshiyuki Kubo, Hiroaki Miura, Kairi Ri, Ayaka Tomise, Shin-ichi Akanuma, Ken-ichi Hosoya
Publikováno v:
International Journal of Molecular Sciences, Vol 24, Iss 10, p 9003 (2023)
Putrescine is a bioactive polyamine. Its retinal concentration is strictly controlled to maintain a healthy sense of vision. The present study investigated putrescine transport at the blood–retinal barrier (BRB) to gain a better understanding of th
Externí odkaz:
https://doaj.org/article/88dbadca184542a1a91014f6eeb6c015
Publikováno v:
Pharmaceuticals, Vol 16, Iss 3, p 435 (2023)
Blood-to-retina transport across the inner blood–retinal barrier (BRB) is a key determinant of retinal drug concentration and pharmacological effect. Recently, we reported on the amantadine-sensitive drug transport system, which is different from w
Externí odkaz:
https://doaj.org/article/a2f40a9284ec46dda84be739301369da
Autor:
Toshiki Kurosawa, Yuma Tega, Yasuo Uchida, Kei Higuchi, Hidetsugu Tabata, Takaaki Sumiyoshi, Yoshiyuki Kubo, Tetsuya Terasaki, Yoshiharu Deguchi
Publikováno v:
Pharmaceutics, Vol 14, Iss 8, p 1683 (2022)
A proton-coupled organic cation (H+/OC) antiporter working at the blood–brain barrier (BBB) in humans and rodents is thought to be a promising candidate for the efficient delivery of cationic drugs to the brain. Therefore, it is important to identi
Externí odkaz:
https://doaj.org/article/946ddae06db648bb9cfcbb6d68310c91
Publikováno v:
Journal of Clinical and Translational Science, Vol 6, Pp 87-87 (2022)
OBJECTIVES/GOALS: We have shown that glioblastoma upregulates blood-brain barrier drug efflux transporters via a mechanism that likely involves TNFα and PI3K/Akt. Our goal is to repurpose FDA-approved PI3K/Akt inhibitors to increase anticancer dru
Externí odkaz:
https://doaj.org/article/368f87376b5441f28ae2b84ffd14fd22
Autor:
Katsuhisa Inoue, Tomoko Yamaguchi, Yoshiharu Deguchi, Kenji Kawabata, Tatsuki Mochizuki, Toshiki Kurosawa, Yuma Tega, Hiroyuki Kusuhara, Daiki Sako, Naoki Ito
Publikováno v:
Journal of Pharmaceutical Sciences. 110:3484-3490
The likelihood of reoccurrence of acute lymphoblastic leukemia is influenced by the cerebral concentration of the therapeutic agent 6-mercaptopurine (6-MP) during treatment. Therefore, it is important to understand the blood-brain barrier (BBB) trans
Autor:
Yuma Tega, Toshinari Takeuchi, Masatoshi Nagano, Reina Makino, Yoshiyuki Kubo, Shin-ichi Akanuma, Ken-ichi Hosoya
Publikováno v:
Drug Metabolism and Pharmacokinetics. :100510
Autor:
Toshiki Kurosawa, Daiki Sako, Yuma Tega, Yasuyuki Debori, Yumi Tomihara, Kazunobu Aoyama, Yoshiyuki Kubo, Nobuyuki Amano, Yoshiharu Deguchi
Publikováno v:
Pharmaceutical research. 39(7)
Purpose The purpose of this study was to construct and validate an in vitro three-dimensional blood–brain barrier (3DBBB) model system equipped with brain microvascular endothelial cells derived from human induced pluripotent stem cells (hiPS-BMECs
Autor:
Toshiki Kurosawa, Daiki Sako, Yuma Tega, Yasuyuki Debori, Yumi Tomihara, Kazunobu Aoyama, Yoshiyuki Kubo, Nobuyuki Amano, Yoshiharu Deguchi
Publikováno v:
Pharmaceutical Research. 39:1661-1661
Autor:
Atsushi Kitamura, Yoshiharu Deguchi, Yuma Tega, Fumio Itagaki, Hidetsugu Tabata, Tetsuta Oshitari, Toshiki Kurosawa
Publikováno v:
Journal of pharmaceutical sciences. 110(1)
There is increasing evidence that a proton-coupled organic cation (H+/OC) antiporter facilitates uptake of various central nervous system-active drugs, such as the histamine H1 receptor antagonist diphenhydramine, into the brain. The purpose of this
Autor:
Tadahaya Mizuno, Hiroyuki Kusuhara, Yoshitane Nozaki, Yuma Tega, Tatsuki Mochizuki, Kenji Kawabata, Yoshiharu Deguchi, Kei Higuchi, Toshiki Kurosawa, Tomoko Yamaguchi
Publikováno v:
Drug metabolism and disposition: the biological fate of chemicals. 49(1)
Understanding the mechanisms of drug transport across the blood-brain barrier (BBB) is an important issue for regulating the pharmacokinetics of drugs in the central nervous system. In this study, we focused on solute carrier family 35, member F2 (SL