Median raphe serotonergic neurons projecting to the interpeduncular nucleus control preference and aversion

Autor: Hiroyuki Kawai, Youcef Bouchekioua, Naoya Nishitani, Kazuhei Niitani, Shoma Izumi, Hinako Morishita, Chihiro Andoh, Yuma Nagai, Masashi Koda, Masako Hagiwara, Koji Toda, Hisashi Shirakawa, Kazuki Nagayasu, Yu Ohmura, Makoto Kondo, Katsuyuki Kaneda, Mitsuhiro Yoshioka, Shuji Kaneko

Publikováno v: Nature Communications, Vol 13, Iss 1, Pp 1-22 (2022)

Appropriate processing of value information is essential for survival. Here the authors show that in mice, serotonergic activations originating from the median raphe nucleus facilitated aversion in a pathway-dependent manner, while silencing this pat

Externí odkaz: https://doaj.org/article/71c32d54f9e1485594bbb40a22f388b8

TRPM2 confers susceptibility to social stress but is essential for behavioral flexibility

Autor: Yuma Nagai, Tsuyoshi Miyakawa, Kazuki Nagayasu, Shuji Kaneko, Takayuki Nakagawa, Keizo Takao, Yasuo Mori, Naoya Nishitani, Emina Hashimoto, Hisashi Shirakawa, Chihiro Andoh

Publikováno v: Brain Research Reviews. 1704:68-77

Transient receptor potential melastatin 2 (TRPM2) is a Ca2+-permeable, nonselective cation channel and a member of the TRP channel superfamily that acts as a sensor of intracellular redox states. TRPM2 is widely distributed in many tissues and highly

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::cf3418f14cbd5e29b7993a4df9f51838
http://hdl.handle.net/2433/241623

Manipulation of dorsal raphe serotonergic neurons modulates active coping to inescapable stress and anxiety-related behaviors in mice and rats

Autor: Takayuki Nakagawa, Hisashi Shirakawa, Haruko Kinoshita, Hitoshi Hashimoto, Sergey Kasparov, Norihiro Shibui, Nozomi Asaoka, Mayumi Yamashiro, Hiroyuki Kawai, James Hewinson, Shuji Kaneko, Beihui Liu, Chihiro Andoh, Kazuki Nagayasu, Naoya Nishitani, Yuma Nagai

Publikováno v: Neuropsychopharmacology

Major depression and anxiety disorders are a social and economic burden worldwide. Serotonergic signaling has been implicated in the pathophysiology of these disorders and thus has been a crucial target for pharmacotherapy. However, the precise mecha

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7c2083c6f635bb6e18028b3d9d87e835
http://europepmc.org/articles/PMC6372597

Identification of neuron-type specific promoters in monkey genome and their functional validation in mice

Autor: Masaharu Yasuda, Yasumasa Ueda, Yuma Nagai, Hisashi Shirakawa, Sergey Kasparov, Takayuki Nakagawa, Ken-ichi Inoue, Kae Nakamura, Shuji Kaneko, Yuto Fukui, Kazuki Nagayasu, Naoya Nishitani, Chihiro Andoh

Publikováno v: Nagai, Y, Nishitani, N, Yasuda, M, Ueda, Y, Fukui, Y, Andoh, C, Shirakawa, H, Nakagawa, T, Inoue, K, Nagayasu, K, Kasparov, S, Nakamura, K & Kaneko, S 2019, ' Identification of neuron-type specific promoters in monkey genome and their functional validation in mice ', Biochemical and Biophysical Research Communications, vol. 518, no. 4, pp. 619-624 . https://doi.org/10.1016/j.bbrc.2019.08.101

Viral gene delivery is one of the most versatile techniques for elucidating the mechanisms underlying brain dysfunction, such as neuropsychiatric disorders. Due to the complexity of the brain, expression of genetic tools, such as channelrhodopsin and

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::c29a16e76ed303b538f338d100dd68f9
https://research-information.bris.ac.uk/ws/files/213088099/190417_Nagai_et_al_2019_R1_highlight_.pdf

An essential role of the median raphe serotonin neurons projecting to the interpeduncular nucleus in reward processing

Autor: Masashi Koda, Kazuki Nagayasu, Naoya Nishitani, Shuji Kaneko, Kawai Hiroyuki, Yuma Nagai, Hisashi Shirakawa

Publikováno v: Proceedings for Annual Meeting of The Japanese Pharmacological Society. 94:2-Y

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_________::741fcac8af78e3ae998fca544859c395
https://doi.org/10.1254/jpssuppl.94.0_2-y-f3-1