Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Yuma Hanawa"'
Publikováno v:
FEBS Letters. 591:1862-1871
Destabilization of human transthyretin (TTR) has been implicated in its misfolding and aggregation. A previous study on the neutron crystal structure of TTR suggested that a large hydrogen bond network around H88 which includes water molecules is sig
The effect of amino acid substitution at position 88 on the structure and stability of transthyretin
Publikováno v:
Amyloid. 26:43-44
Hereditary transthyretin (TTR)-related amyloidosis (ATTR) is an autosomal dominant disorder caused by mutations of the TTR gene. ATTR caused by His88Arg mutation is characterized by a severe amyloi...