Zobrazeno 1 - 2
of 2
pro vyhledávání: '"Yuliya V. Meshkova"'
Autor:
Mikhail V. Khvostov, Elizaveta D. Gladkova, Sergey A. Borisov, Nataliya A. Zhukova, Mariya K. Marenina, Yuliya V. Meshkova, Olga A. Luzina, Tatijana G. Tolstikova, Nariman F. Salakhutdinov
Publikováno v:
Pharmaceutics, Vol 13, Iss 12, p 2138 (2021)
Berberine is well known for its ability to reduce the blood glucose level, but its high effective dose and poor bioavailability limits its use. In this work we synthesized a new derivative of berberine, 9-(hexylamino)-2,3-methylenedioxy-10-methoxypro
Externí odkaz:
https://doaj.org/article/d3ff762f24764daa83ac048dcd39e581
Autor:
Mikhail V. Khvostov, Elizaveta D. Gladkova, Sergey A. Borisov, Marina S. Fedotova, Nataliya A. Zhukova, Mariya K. Marenina, Yuliya V. Meshkova, Olga A. Luzina, Tatiana G. Tolstikova, Nariman F. Salakhutdinov
Publikováno v:
International Journal of Molecular Sciences; Volume 23; Issue 22; Pages: 14186
Novel 9-N-alkyltetrahydroberberine derivatives were synthesized, among which, based on the results of OGTT, one compound containing the longest aliphatic substituent was selected for study in mice C57BL/6Ay, which demonstrate obesity, impaired glucos