European contribution to the study of ROS: A summary of the findings and prospects for the future from the COST action BM1203 (EU-ROS)

Autor: Javier Egea, Isabel Fabregat, Yves M. Frapart, Pietro Ghezzi, Agnes Görlach, Thomas Kietzmann, Kateryna Kubaichuk, Ulla G. Knaus, Manuela G. Lopez, Gloria Olaso-Gonzalez, Andreas Petry, Rainer Schulz, Jose Vina, Paul Winyard, Kahina Abbas, Opeyemi S. Ademowo, Catarina B. Afonso, Ioanna Andreadou, Haike Antelmann, Fernando Antunes, Mutay Aslan, Markus M. Bachschmid, Rui M. Barbosa, Vsevolod Belousov, Carsten Berndt, David Bernlohr, Esther Bertrán, Alberto Bindoli, Serge P. Bottari, Paula M. Brito, Guia Carrara, Ana I. Casas, Afroditi Chatzi, Niki Chondrogianni, Marcus Conrad, Marcus S. Cooke, João G. Costa, Antonio Cuadrado, Pham My-Chan Dang, Barbara De Smet, Bilge Debelec–Butuner, Irundika H.K. Dias, Joe Dan Dunn, Amanda J. Edson, Mariam El Assar, Jamel El-Benna, Péter Ferdinandy, Ana S. Fernandes, Kari E. Fladmark, Ulrich Förstermann, Rashid Giniatullin, Zoltán Giricz, Anikó Görbe, Helen Griffiths, Vaclav Hampl, Alina Hanf, Jan Herget, Pablo Hernansanz-Agustín, Melanie Hillion, Jingjing Huang, Serap Ilikay, Pidder Jansen-Dürr, Vincent Jaquet, Jaap A. Joles, Balaraman Kalyanaraman, Danylo Kaminskyy, Mahsa Karbaschi, Marina Kleanthous, Lars-Oliver Klotz, Bato Korac, Kemal Sami Korkmaz, Rafal Koziel, Damir Kračun, Karl-Heinz Krause, Vladimír Křen, Thomas Krieg, João Laranjinha, Antigone Lazou, Huige Li, Antonio Martínez-Ruiz, Reiko Matsui, Gethin J. McBean, Stuart P. Meredith, Joris Messens, Verónica Miguel, Yuliya Mikhed, Irina Milisav, Lidija Milković, Antonio Miranda-Vizuete, Miloš Mojović, María Monsalve, Pierre-Alexis Mouthuy, John Mulvey, Thomas Münzel, Vladimir Muzykantov, Isabel T.N. Nguyen, Matthias Oelze, Nuno G. Oliveira, Carlos M. Palmeira, Nikoletta Papaevgeniou, Aleksandra Pavićević, Brandán Pedre, Fabienne Peyrot, Marios Phylactides, Gratiela G. Pircalabioru, Andrew R. Pitt, Henrik E. Poulsen, Ignacio Prieto, Maria Pia Rigobello, Natalia Robledinos-Antón, Leocadio Rodríguez-Mañas, Anabela P. Rolo, Francis Rousset, Tatjana Ruskovska, Nuno Saraiva, Shlomo Sasson, Katrin Schröder, Khrystyna Semen, Tamara Seredenina, Anastasia Shakirzyanova, Geoffrey L. Smith, Thierry Soldati, Bebiana C. Sousa, Corinne M. Spickett, Ana Stancic, Marie José Stasia, Holger Steinbrenner, Višnja Stepanić, Sebastian Steven, Kostas Tokatlidis, Erkan Tuncay, Belma Turan, Fulvio Ursini, Jan Vacek, Olga Vajnerova, Kateřina Valentová, Frank Van Breusegem, Lokman Varisli, Elizabeth A. Veal, A. Suha Yalçın, Olha Yelisyeyeva, Neven Žarković, Martina Zatloukalová, Jacek Zielonka, Rhian M. Touyz, Andreas Papapetropoulos, Tilman Grune, Santiago Lamas, Harald H.H.W. Schmidt, Fabio Di Lisa, Andreas Daiber

Publikováno v: Redox Biology, Vol 13, Iss C, Pp 94-162 (2017)

The European Cooperation in Science and Technology (COST) provides an ideal framework to establish multi-disciplinary research networks. COST Action BM1203 (EU-ROS) represents a consortium of researchers from different disciplines who are dedicated t

Externí odkaz: https://doaj.org/article/637c0e34ca5240b4924d5b20463b39fc

Redox regulation of genome stability by effects on gene expression, epigenetic pathways and DNA damage/repair

Autor: Yuliya Mikhed, Agnes Görlach, Ulla G. Knaus, Andreas Daiber

Publikováno v: Redox Biology, Vol 5, Iss , Pp 275-289 (2015)

Reactive oxygen and nitrogen species (e.g. H2O2, nitric oxide) confer redox regulation of essential cellular signaling pathways such as cell differentiation, proliferation, migration and apoptosis. In addition, classical regulation of gene expression

Externí odkaz: https://doaj.org/article/b30442894d004871985dabc11ea42983

Heparan Sulfate-Editing Extracellular Sulfatases Enhance VEGF Bioavailability for Ischemic Heart Repair

Autor: Mortimer Korf-Klingebiel, Marc R. Reboll, Karsten Grote, Hauke Schleiner, Yong Wang, Xuekun Wu, Stefanie Klede, Yuliya Mikhed, André Nobre, Johann Bauersachs, Michael Klintschar, Carsten Rudat, Andreas Kispert, Hans W. Niessen, Torben Lübke, Thomas Dierks, Kai C. Wollert

Publikováno v: Circulation Research, 125(9), 787-801. Lippincott Williams and Wilkins
Korf-Klingebiel, M, Reboll, M R, Grote, K, Schleiner, H, Wang, Y, Wu, X, Klede, S, Mikhed, Y, Bauersachs, J, Klintschar, M, Rudat, C, Kispert, A, Niessen, H W, Lübke, T, Dierks, T & Wollert, K C 2019, ' Heparan Sulfate-Editing Extracellular Sulfatases Enhance VEGF Bioavailability for Ischemic Heart Repair ', Circulation Research, vol. 125, no. 9, pp. 787-801 . https://doi.org/10.1161/CIRCRESAHA.119.315023

Rationale: Mechanistic insight into the inflammatory response after acute myocardial infarction may inform new molecularly targeted treatment strategies to prevent chronic heart failure. Objective: We identified the sulfatase SULF2 in an in silico se

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a8959bee0d960c50e42866a444cc284f
https://research.vumc.nl/en/publications/d0749b94-b9a4-496e-9553-258db6dd716c

Uncoupling of Endothelial Nitric Oxide Synthase in Perivascular Adipose Tissue of Diet-Induced Obese Mice

Autor: Alice Habermeier, Andreas Daiber, Ellen I. Closs, Yuliya Mikhed, Adrian Gericke, Ning Xia, Huige Li, Ulrich Förstermann, Gisela Reifenberg, Thomas Münzel, Sven Horke

Publikováno v: Arteriosclerosis, Thrombosis, and Vascular Biology. 36:78-85

Objective— The present study was conducted to investigate the contribution of perivascular adipose tissue (PVAT) to vascular dysfunction in a mouse model of diet-induced obesity. Approach and Results— Obesity was induced in male C57BL/6J mice wit

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a19630da5d3b64d43231050707eeba3c
https://doi.org/10.1161/atvbaha.115.306263

Formation of 2-nitrophenol from salicylaldehyde as a suitable test for low peroxynitrite fluxes

Autor: Stefan Schildknecht, Matthias Oelze, Andreas Daiber, Michael Jörg, Thomas Münzel, Volker Ullrich, Karl J. Lackner, Mobin Dib, Yuliya Mikhed, Kai Bruns

Publikováno v: Redox Biology
Redox Biology, Vol 7, Iss C, Pp 39-47 (2016)

There has been some dispute regarding reaction products formed at physiological peroxynitrite fluxes in the nanomolar range with phenolic molecules, when used to predict the behavior of protein-bound aromatic amino acids like tyrosine. Previous data

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::3d5b180dd1964341196b739279df2997
http://europepmc.org/articles/PMC4683390