Effect of Casein Kinase 1a Activator Pyrvinium Pamoate on Erythrocyte Ion Channels

Autor: Matthias Eberhard, Syed M. Qadri, Florian Lang, Christine Zelenak, Yuliya Kucherenko

Publikováno v: Cellular Physiology and Biochemistry. 30:407-417

Pharmacological modification of protein kinase CK1 (casein kinase 1) has previously been shown to influence suicidal erythrocyte death or eryptosis, which is triggered by activation of Cl(-)-sensitive Ca(2+)-permeable cation channels. Ca(2+) entering

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::5744f94bf4f3395731f9fa79685b681a
https://doi.org/10.1159/000339034

Blunted IgE-mediated activation of mast cells in mice lacking the serum- and glucocorticoid-inducible kinase SGK3

Autor: Irina M. Zemtsova, Henning Fröhlich, Syed M. Qadri, Yuliya Kucherenko, Krishna M. Boini, Florian Lang, Ekaterina Shumilina, David A. Pearce, Nicole Heise

Publikováno v: American Journal of Physiology-Cell Physiology. 299:C1007-C1014

Previous studies have shown that pharmacological inhibition of the phosphoinositol-3 (PI3) kinase disrupts the activation of mast cells. Through phosphoinositide-dependent kinase PDK1, PI3 kinase activates the serum- and glucocorticoid-inducible kina

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68ebfa4d6e588c40fbaffb8e4bc9f19a
https://doi.org/10.1152/ajpcell.00539.2009

Modulation of suicidal erythrocyte cation channels by an AMPA antagonist

Autor: Hasan Mahmud, Elisa Floride, Yuliya Kucherenko, Michael Föller, Eva Maria Gehring, Ekaterina Shumilina, Florian Lang, Shuchen Gu, Rolf Sprengel

Publikováno v: Journal of Cellular and Molecular Medicine

In neurons alpha-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors are heteromeric cation channels composed of different sub-units, including GluA1-GluA4. When expressed without GluA2, AMPA receptors function as Ca(2+)-permeable cat

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::69b20fff2dc2aa2cc4a0bd8dfbd16c93
https://doi.org/10.1111/j.1582-4934.2009.00745.x

Decreased redox-sensitive erythrocyte cation channel activity in aquaporin 9-deficient mice

Autor: Søren Nielsen, Yuliya Kucherenko, Florian Lang, Stephan M. Huber

Publikováno v: Kucherenko, Y V, Huber, S S M, Nielsen, S & Lang, F 2012, ' Decreased redox-sensitive erythrocyte cation channel activity in aquaporin 9-deficient mice ', Journal of Membrane Biology, vol. 245, no. 12, pp. 797-805 . https://doi.org/10.1007/s00232-012-9482-y

Survival of the malaria pathogen Plasmodium falciparum in host erythrocytes requires the opening of new permeability pathways (NPPs) in the host cell membrane, accomplishing entry of nutrients, exit of metabolic waste products such as lactate and mov

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=doi_dedup___::7b36484aac15546881c8c4faad90f924
https://pure.au.dk/portal/da/publications/decreased-redoxsensitive-erythrocyte-cation-channel-activity-in-aquaporin-9deficient-mice(ce5c143e-90d4-459d-bf67-80c6e2d3e129).html

Dicoumarol activates Ca2+-permeable cation channels triggering erythrocyte cell membrane scrambling

Autor: Syed M, Qadri, Yuliya, Kucherenko, Christine, Zelenak, Kashif, Jilani, Elisabeth, Lang, Florian, Lang

Publikováno v: Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology. 28(5)

Dicoumarol, a widely used anticoagulant, may cause anemia, which may result from enhanced erythrocyte loss due to bleeding or due to accelerated erythrocyte death. Erythrocytes may undergo suicidal death or eryptosis, characterized by cell shrinkage

Externí odkaz: https://explore.openaire.eu/search/publication?articleId=pmid________::952f50e0673e6971e9f06e19c74f0bbf
https://pubmed.ncbi.nlm.nih.gov/22178938