Zobrazeno 1 - 10
of 11
pro vyhledávání: '"Yuliya A. Pustylnyak"'
Autor:
Mark E. Mazin, Andrei A. Yarushkin, Yuliya A. Pustylnyak, Elena A. Prokopyeva, Vladimir O. Pustylnyak
Publikováno v:
Molecular Biology Reports. 49:4089-4093
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_________::0d55db09542cb7b746b742757ee2756e
https://doi.org/10.1007/s11033-022-07340-1
https://doi.org/10.1007/s11033-022-07340-1
Autor:
Mark E, Mazin, Andrei A, Yarushkin, Yuliya A, Pustylnyak, Elena A, Prokopyeva, Vladimir O, Pustylnyak
Publikováno v:
Molecular biology reports. 49(5)
The constitutive androstane receptor (CAR, NR1I3)-mediated mechanisms regulating hepatocyte proliferation and growth of the liver did not yet experience complete elucidation. We investigated whether STAT3 could be activated in vivo by NR1I3 signaling
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=pmid________::ba9a7cae442c3e83ac332a1af9e6f23f
https://pubmed.ncbi.nlm.nih.gov/35305226
https://pubmed.ncbi.nlm.nih.gov/35305226
Publikováno v:
International Journal of Molecular Sciences
International Journal of Molecular Sciences, Vol 21, Iss 6735, p 6735 (2020)
International Journal of Molecular Sciences, Vol 21, Iss 6735, p 6735 (2020)
The constitutive androstane receptor (CAR, NR1I3) is extremely important for the regulation of many physiological processes, especially xenobiotic (drug) metabolism and transporters. CAR differs from steroid hormone receptors in that it can be activa
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::b7cb49b36a267230a201be7a2a605980
http://europepmc.org/articles/PMC7555422
http://europepmc.org/articles/PMC7555422
Autor:
Vladimir O. Pustylnyak, Andrei A. Yarushkin, Mark E. Mazin, Yuliya A. Pustylnyak, Elena A. Prokopyeva
Publikováno v:
European journal of pharmacology. 879
It is well known that activating the constitutive androstane receptor (CAR, NR1I3) leads to a significant proliferation of liver cells, which suggests that NR1I3 could be a therapeutic target for the partial resection of this organ. Studies describin
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::8181a3487a98c0c95ebaadbbf54b90d9
https://pubmed.ncbi.nlm.nih.gov/32339513
https://pubmed.ncbi.nlm.nih.gov/32339513
Autor:
Vladimir O. Pustylnyak, Yuliya A. Pustylnyak, Mark E. Mazin, Elena A. Prokopyeva, Andrei A. Yarushkin
Publikováno v:
Archives of biochemistry and biophysics. 672
Recently, we reported that treatment with the mouse agonist of the constitutive androstane receptor (CAR), 1,4-bis benzene[2-(3,5-dichloropyridyloxy)] (TCPOBOP; a well-known hepatomitogen), reduced PTEN protein levels, leading to Akt activation. Henc
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::134e9572b1d2c871f4e716db66d42c71
https://pubmed.ncbi.nlm.nih.gov/31394088
https://pubmed.ncbi.nlm.nih.gov/31394088
Autor:
Diana N. Markova, Yuliya A. Kazantseva, Andrei A. Yarushkin, Elena A. Prokopyeva, Yuliya A. Pustylnyak, Vladimir O. Pustylnyak
Publikováno v:
Biochemical and Biophysical Research Communications. 478:1099-1105
It is well-known that constitutive androstane receptor (CAR) activation by 1,4-bis[2-(3,5-dichloropyridyloxy)]benzene (TCPOBOP) increases the liver-to-body weight ratio. CAR-mediated liver growth is correlated with increased expression of the pleiotr
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::43d6a921eeecff647e2a41dce5eb6571
https://doi.org/10.1016/j.bbrc.2016.08.075
https://doi.org/10.1016/j.bbrc.2016.08.075
Autor:
Yuliya A. Pustylnyak, Vladimir O. Pustylnyak, Andrei A. Yarushkin, Mark E. Mazin, Kseniya V. Korchagina, Anastasia Y. Yunusova, Elena A. Prokopyeva
Publikováno v:
Biochemical and biophysical research communications. 504(2)
It was shown that CAR participates in the regulation of many cell processes. Thus, the activation of CAR causes a proliferating effect in the liver, which provides grounds to consider CAR as a therapeutic target when having a partial resection of thi
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::996112cb501289d96758972286613662
https://pubmed.ncbi.nlm.nih.gov/29890134
https://pubmed.ncbi.nlm.nih.gov/29890134
Xenosensor CAR mediates down-regulation of miR-122 and up-regulation of miR-122 targets in the liver
Autor:
Yuliya A. Kazantseva, Andrei A. Yarushkin, Lyudmila A. Mostovich, Vladimir O. Pustylnyak, Yuliya A. Pustylnyak
Publikováno v:
Toxicology and Applied Pharmacology. 288:26-32
MiR-122 is a major hepatic microRNA, accounting for more than 70% of the total liver miRNA population. It has been shown that miR-122 is associated with liver diseases, including hepatocellular carcinoma. Mir-122 is an intergenic miRNA with its own p
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::68992a4d73825de15460aa3c2bed0d5e
https://doi.org/10.1016/j.taap.2015.07.004
https://doi.org/10.1016/j.taap.2015.07.004
Autor:
Vyacheslav S. Kobelev, Vladimir O. Pustylnyak, Yuliya A. Kazantseva, Yuliya A. Pustylnyak, Andrei A. Yarushkin
Publikováno v:
European journal of pharmacology. 797
Although NR1C3 agonists inhibit cell growth, the molecular mechanism of their action has not been thoroughly characterized to date. A recent study demonstrated that NR1C3 can regulate miR-122 by binding to its promoter. Given that miR-122 can indirec
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::a1a293fba23b45406caec7407d588987
https://pubmed.ncbi.nlm.nih.gov/28095325
https://pubmed.ncbi.nlm.nih.gov/28095325
Publikováno v:
Biochemistry. Biokhimiia. 81(4)
Activation of the constitutive androstane receptor (CAR) in hepatocytes occurs as a body adaptation in response to a number of external influences, and its functional activity is primarily related to induction of enzymes detoxifying xenobiotics. Howe
Externí odkaz:
https://explore.openaire.eu/search/publication?articleId=doi_dedup___::ddab0f5443edf42b5d1414eef81aceb3
https://pubmed.ncbi.nlm.nih.gov/27293091
https://pubmed.ncbi.nlm.nih.gov/27293091